Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo

Abstract

We conclude that neuropeptides such as neurokinin A and substance P do not directly contribute to the development of PIB after allergic reaction.

β‐blocker induced asthma: a role for sensory nerve hyperresponsiveness?

“…may be more profound if the inhibitory braking' action of circulating adrenaline is removed bŷ 5-blockade. However, Fujimura et al [6] have demonstrated that an NK[ and NK2 dual antagonist FK 224 or a selective NK| antagonist FK888 did not reduce PIB developed after antigen inhalation in passively sensitized guinea-pigs, suggesting that sensory nerve hyperresponsiveness may not be involved in this phenomenon. However, more conclusive data await experiments using both a selective NK] and NK^ receptor antagonist in combination.…”

“…Fujimura el al. [6] have investigated whether sensory neuropeptides are involved in the genesis of PIB in an animal model. Sensory nerve hyperresponsiveness could be involved in atropine sensitive and insensitive 0blocker-induced bronchoconstriction as SP and NKA can facilitate cholinergic neurotransmission leading to enhanced cholinergic bronchoconstriction [29] which would be atropine-sensitive (Fig.…”

“…This drug-induced asthma, which can result in death, highlights a major defect in the control of airway tone in asthmatics, the mechanism behind which is unknown and warrants investigation. In this issue of the Journal, Fujimura i'l ai have investigated whether sensory neuropeptides are involved in the bronchoconstriction evoked by the /3-blocker, propranolol, in an animal model of 0blocker-induced asthma [6].…”