Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy

Kim, Ji Jeong; Shin, Yun A; Suk, Min Hwa

doi:10.5717/jenb.2015.15092812

Cited by 17 publications

(12 citation statements)

References 55 publications

(55 reference statements)

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“…Kim et al (24) examined the effects of 12 weeks of walking on body composition and immune system in patients with breast cancer. This study was consistent with our findings regarding weight, fat per-centage, and BMI (24).…”

Section: Discussionsupporting

confidence: 94%

The Effects of Concurrent Training on the Body Composition, Quality of Life, and Sleep Quality of Postmenopausal Women with Breast Cancer

Monazzami

Momenpour

Alipoor

et al. 2020

J Kermanshah Univ Med Sci

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Background: Concurrent training is more effective in developing fitness indicators than doing endurance and resistance training separately. However, there has been limited research to evaluate the effects of this type of exercise training on improvement of body composition and quality of life indicators in postmenopausal women with cancer. Objectives: The present study aimed to determine the effects of eight weeks of concurrent training on body composition, quality of life, and sleep quality in postmenopausal women with breast cancer. Methods: This study was conducted on 42 women with breast cancer who were selected randomly and divided into exercise training and control groups. The training group followed eight weeks of resistance training (2 - 3 sets, 10 - 18 repetitions, and 50% - 70% 1RM) and aerobic training (50% - 70% maximum heart rate, 12 - 14 Borg scale, and 20 - 40 minutes). Anthropometric characteristics were measured based on body composition (ZEUS 9.9), the sleep quality was measured by the Pittsburgh sleep quality index (PSQI), and the quality of life was measured by the McGill quality of life (MQOL) questionnaire. Two-way repeated measures ANOVA has been used for McGill’s analysis of variance (P < 0.05). Results: The results showed a significant decrease in sleep quality score, weight, fat percentage, BMI, and waist circumference in the training group (P < 0.05), as well as an increase in quality of life index in the training group (P < 0.05). However, no significant changes were observed in the Waist-hip ratio (WHR) values of the training group compared with the control group (P > 0.05). Conclusions: Although the changes in WHR index were not significant after eight weeks of concurrent training, this type of training program could be considered as a beneficial way for improving body composition, quality of life, and sleep quality in patients with breast cancer.

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Section: Discussionsupporting

confidence: 94%

The Effects of Concurrent Training on the Body Composition, Quality of Life, and Sleep Quality of Postmenopausal Women with Breast Cancer

Monazzami

Momenpour

Alipoor

et al. 2020

J Kermanshah Univ Med Sci

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“…Similarly, in breast cancer patients undergoing chemotherapy, a single aerobic exercise, such as a walking training program (performed 5 consecutive days per week, for 12 weeks), caused a significant weight and body fat percent reduction [ 38 ]. In prostate cancer patient receiving androgen deprivation therapy, a 3-month exercise programme (performed twice a week) that combined exercise and resistance training preserved appendicular lean mass decay and prevented gains in whole body fat mass [ 39 ].…”

Section: Physical Aspectsmentioning

confidence: 99%

Impact of physical exercise in cancer survivors during and after antineoplastic treatments

et al. 2018

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Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom we discuss causes, therapies, we analyse the effects of physical exercise and we summarize the most effective type of exercise to reduce the symptoms. This review also points out what are the difficulties that patients and survivors face during the practice of physical activity and provides some solutions to overcome these barriers.Related to each specific cancer, it emerges that type, frequency and intensity of physical exercise could be prescribed and supervised as a therapeutic program, like it occurs for the type, dose and duration of a drug treatment.

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“…Similar to preclinical studies, the frequency, duration, intensity and timeline of the PA interventions were highly heterogeneous in the clinical studies. To evaluate if the timing of the PA intervention in relation to cancer treatment may significantly impact immune outcomes, we classified the included studies into three categories: PA intervention performed prior to ( n = 1) ( 58 ), during ( n = 3) ( 39 , 59 , 60 ), and post treatment ( n = 19) ( 61 – 79 ).…”

Section: Resultsmentioning

confidence: 99%

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators

Rogers

2020

Front. Nutr.

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There is strong evidence that physical activity (PA) reduces risk, recurrence, and mortality from breast cancer. Emerging data suggest that PA induces changes in inflammatory and immune mediators that may contribute to beneficial effects on breast cancer outcomes. Thus, the goal of this review was to evaluate the evidence linking the protective benefit of PA to modulation of immune responses in breast cancer. A literature search was conducted to identify studies that evaluated the impact of PA on tumor and immune outcomes in breast cancer patients and in mammary tumor models. Nineteen studies investigated the effect of PA interventions on cancer immune outcomes using preclinical breast cancer models. Tumor growth was reduced in 11 studies, unchanged in three studies, and increased in one study. Spontaneous metastasis was reduced in two studies and survival was improved in four studies. Frequently assessed immune outcomes include splenic cell number and function, circulating inflammatory cytokines, and intratumoral immune cells and inflammatory markers. Circulating inflammatory cytokine responses were heterogeneous in preclinical models. Within the tumor microenvironment (TME), several studies documented a change in the infiltration of immune cells with an increase in effector cells and a reduction in immune suppressive cells. Twenty-three studies investigated the effect of PA interventions on immune outcomes in breast cancer patients. Thirteen studies used aerobic PA interventions and 10 studies used a combination of aerobic and resistance exercise interventions. Cycling and treadmill activities were the most commonly used PA modalities. Circulating immune cells and inflammatory cytokines were the most frequently assessed immune outcomes in the clinical studies. Among the 19 studies that evaluated a PA intervention during the post treatment period, 10 reported a reduction in the levels of at least one inflammatory cytokine. No inflammatory cytokines were quantified in the three studies that evaluated a PA intervention during treatment with chemotherapy. Immune outcomes within the tumor were assessed in only one study performing a PA intervention prior to surgery. Results from preclinical and clinical studies suggest that PA exerts heterogeneous effects on inflammatory cytokines, but may alter the gene expression profile and immune infiltrates in the tumor which may result in a reduction in immunosuppressive factors. However, additional studies are needed to better understand the effect of PA on immune outcomes in the TME.

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Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy

Cited by 17 publications

References 55 publications

The Effects of Concurrent Training on the Body Composition, Quality of Life, and Sleep Quality of Postmenopausal Women with Breast Cancer

The Effects of Concurrent Training on the Body Composition, Quality of Life, and Sleep Quality of Postmenopausal Women with Breast Cancer

Impact of physical exercise in cancer survivors during and after antineoplastic treatments

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators

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