Effect of 4-Chloromethyl-2-Methyl-2-Pentyl-1,3-Dioxolane (Ay-22,352) on the Fertilizing Ability of Hamster Epididymal Spermatozoa

Lubicz-Nawrocki, C. M.; Chang, M. C.

doi:10.1530/jrf.0.0430281

Reproduction

1975

DOI: 10.1530/jrf.0.0430281

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Effect of 4-Chloromethyl-2-Methyl-2-Pentyl-1,3-Dioxolane (Ay-22,352) on the Fertilizing Ability of Hamster Epididymal Spermatozoa

C. M. Lubicz-Nawrocki¹,

M. C. Chang²

Abstract: Summary. Fertile male hamsters were injected subcutaneously with 352

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1978

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Cited by 7 publications

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Inhibition of the metabolism of ram spermatozoa by derivatives of α‐chlorohydrin

1981

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The effects of the male antifertility agent, α‐chlorohydrin, six of its derivatives, and glycidol were studied on the metabolism of washed ram spermatozoa in vitro with fructose as substrate. The α‐chlorohydrin derivatives were the amino, the phosphorylated, and four glycol‐bridge (ketal) compounds. All compounds except glycidol, in a concentration between 0.1 and 100 mM, reduced the aerobic glycolsis and/or oxidation of fructose. However, there was not a high correlation between the ability of these compounds to inhibit the metabolism of ram spermatozoa in vitro and their antifertility activity when administered to male rats. Other factors are clearly involved in their antifertility activity, eg, the concentration of the compounds in the epididymis and their conversion of either more or less spermicidal compounds in the body.

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Inhibition of the metabolism of ram spermatozoa by derivatives of α‐chlorohydrin

1981

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Hormonal control of the bovine oestrous cycle. I. The natural cycle

Peters¹

1985

British Veterinary Journal

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Effects of monothioglycerol, alpha-chlorohydrin and 5-thio-D-glucose on the fertility of male hamster

Das¹,

Yanagimachi

1978

Contraception

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Effect of 4-Chloromethyl-2-Methyl-2-Pentyl-1,3-Dioxolane (Ay-22,352) on the Fertilizing Ability of Hamster Epididymal Spermatozoa

Abstract: Summary. Fertile male hamsters were injected subcutaneously with 352

Cited by 7 publications

References 3 publications

Inhibition of the metabolism of ram spermatozoa by derivatives of α‐chlorohydrin

Inhibition of the metabolism of ram spermatozoa by derivatives of α‐chlorohydrin

Hormonal control of the bovine oestrous cycle. I. The natural cycle

Effects of monothioglycerol, alpha-chlorohydrin and 5-thio-D-glucose on the fertility of male hamster

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