Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on Inflammatory and Apoptosis Processes in Dental Pulp Fibroblasts

Martínez-Herrera, Andrea; Pozos‐Guillén, Amaury; Ruiz-Rodríguez, Socorro; Garrocho‐Rangel, Arturo; Vértiz-Hernández, Ángel Antonio; Escobar‐García, Diana María

doi:10.1155/2016/9371403

Cited by 24 publications

(14 citation statements)

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“…During permanent teeth extractions arise postoperative complications, such as alveolar osteitis, an inflammatory condition with delayed healing and persistent pain [ 61 ]. In this context, Martínez-Herrera and colleagues [ 62 ] reported that eugenol inhibited TNF- α expression and NF- κ B signaling pathway, but not IL-1 β , when fibroblasts was exposed to LPS, confirming its anti-inflammatory property in bone disorders. Curiously, eugenol also induced inflammatory gene mild expression in fibroblasts absence of previous inflammation [ 62 ].…”

Section: Resultsmentioning

confidence: 98%

An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol

Barboza

Filho

Silva

et al. 2018

Oxidative Medicine and Cellular Longevity

200

155

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The bioactive compounds found in foods and medicinal plants are attractive molecules for the development of new drugs with action against several diseases, such as those associated with inflammatory processes, which are commonly related to oxidative stress. Many of these compounds have an appreciable inhibitory effect on oxidative stress and inflammatory response, and may contribute in a preventive way to improve the quality of life through the use of a diet rich in these compounds. Eugenol is a natural compound that has several pharmacological activities, action on the redox status, and applications in the food and pharmaceutical industry. Considering the importance of this compound, the present review discusses its anti-inflammatory and antioxidant properties, demonstrating its mechanisms of action and therapeutic potential for the treatment of inflammatory diseases.

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Section: Resultsmentioning

confidence: 98%

An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol

Barboza

Filho

Silva

et al. 2018

Oxidative Medicine and Cellular Longevity

200

155

View full text Add to dashboard Cite

show abstract

“…As well, in America, clove has been traditionally used in inhibiting food-borne pathogens to treat viruses, worms, candida, and different bacterial and protozoan infections [13]. Moreover, eugenol has been widely used in dentistry because it can penetrate the dental pulp tissue and enter the bloodstream [14]. Sesquiterpenes, isolated from clove were reported to have anti-carcinogenic activity [15].…”

Section: Introductionmentioning

confidence: 99%

Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

et al. 2020

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Herbal medicinal products have been documented as a significant source for discovering new pharmaceutical molecules that have been used to treat serious diseases. Many plant species have been reported to have pharmacological activities attributable to their phytoconstituents such are glycosides, saponins, flavonoids, steroids, tannins, alkaloids, terpenes, etc. Syzygium aromaticum (clove) is a traditional spice that has been used for food preservation and possesses various pharmacological activities. S. aromaticum is rich in many phytochemicals as follows: sesquiterpenes, monoterpenes, hydrocarbon, and phenolic compounds. Eugenyl acetate, eugenol, and β-caryophyllene are the most significant phytochemicals in clove oil. Pharmacologically, S. aromaticum has been examined toward various pathogenic parasites and microorganisms, including pathogenic bacteria, Plasmodium, Babesia, Theileria parasites, Herpes simplex, and hepatitis C viruses. Several reports documented the analgesic, antioxidant, anticancer, antiseptic, anti-depressant, antispasmodic, anti-inflammatory, antiviral, antifungal, and antibacterial activity of eugenol against several pathogenic bacteria including methicillin-resistant Staphylococcus epidermidis and S. aureus. Moreover, eugenol was found to protect against CCl4−induced hepatotoxicity and showed a potential lethal efficacy against the multiplication of various parasites including Giardia lamblia, Fasciola gigantica, Haemonchus contortus, and Schistosoma mansoni. This review examines the phytochemical composition and biological activities of clove extracts along with clove essential oil and the main active compound, eugenol, and implicates new findings from gas chromatography-mass spectroscopy (GC-MS) analysis.

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“…and 962.5 µg/kg b.w. EGL has also been combined with other NSAIDs [28,35,50] and with an ester of aspirin with excellent results and low toxicity at cellular and genomic levels. Li et al [28] mixed EGL, zinc oxide, and poly-methyl-methacrylate in stomatology, obtaining good effects and lower irritability in pulp tissues.…”

Section: Resultsmentioning

confidence: 99%

Antinociceptive Effect of 4-Allyl-2-Methoxyphenol and Diclofenac Co-Administration in the Formalin Test in Rats

GONZÁLEZ-LUGO¹

2022

FARMACIA

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Pain is one of the main ailments that affects humanity. To treat it, non-steroid anti-inflammatory analgesics have been widely used and also opioid analgesics, but to a lesser extent. The use of natural extracts has provided excellent results and represents a new treatment alternative. This study aimed to evaluate the antinociceptive effect of the co-administration of 4-allyl-2methoxyphenol (eugenol; clove essential oil, Syzygium aromaticum) and diclofenac through the formalin test. Eugenoldiclofenac combinations were used at total doses of 725 µg/kg b.w. and 962.5 µg/kg b.w. to measure the antinociception through the formalin test in Wistar Kyoto rats. The combination eugenol-diclofenac in a dose of 962.5 µg/kg b.w. showed the highest effect in the behavioural nociceptive inhibition compared to the combination of 725 µg/kg b.w. and individual treatments (eugenol 1200 µg/kg b.w. and diclofenac 250 µg/kg b.w.). In this context, it was obtained a 92.29 ± 0.64% of antinociception in phase 1 accentuated up to 94.84 ± 0.79% in phase 2. The eugenol and diclofenac combination in the dose of 962.5 µg/kg b.w. showed a supra additive antinociceptive effect, higher than the dose of 725 µg/kg b.w. and the individual doses, which suggests a combination of the antinociceptive mechanisms of eugenol and diclofenac. RezumatScopul acestui studiu a fost evaluarea efectului antinociceptiv al administrării concomitente de 4-alil-2-metoxifenol (eugenol; ulei esențial de cuișoare, Syzygium aromaticum) și diclofenac, utilizând testul formalinei. Combinațiile eugenol-diclofenac au fost utilizate în doze totale de 725 µg/kg corp și 962,5 µg/kg corp pentru a evalua antinocicepția prin testul formalinei la șobolani Wistar Kyoto. Combinația eugenol-diclofenac în doză de 962,5 µg/kg corp a arătat cel mai mare efect în inhibiția nociceptivă comportamentală comparativ cu doza de 725 µg/kg corp și tratamentele individuale (eugenol 1200 µg /kg corp și diclofenac 250 µg/kg corp). În acest context, s-a obținut un rezultat de 92,29 ± 0,64% antinocicepție în faza 1, accentuat până la 94,84 ± 0,79% în faza 2. Combinația eugenol și diclofenac în doza 962,5 µg/kg corp prezintă un efect antinociceptiv supraaditiv mai mare decât doza 725 µg/kg corp și dozele individuale, ceea ce sugerează o combinație de mecanisme antinociceptive ale eugenolului și diclofenacului.

show abstract

Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on Inflammatory and Apoptosis Processes in Dental Pulp Fibroblasts

Cited by 24 publications

References 34 publications

An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol

An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol

Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

Antinociceptive Effect of 4-Allyl-2-Methoxyphenol and Diclofenac Co-Administration in the Formalin Test in Rats

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