An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol

Barboza, Joice Nascimento; Filho, Carlos da Silva Maia Bezerra; Silva, Renan Oliveira; Medeiros, Jand Venes R.; Sousa, Damião Pergentino de

doi:10.1155/2018/3957262

Cited by 196 publications

(136 citation statements)

References 63 publications

(70 reference statements)

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“…Safrole, reported to be a toxic constituent in ARR, is carcinogenic and its metabolites can inhibit the respiratory center [ 30 ]. Eugenol can be used in the treatment of diseases associated with oxidative stress and inflammatory responses through the inhibition of enzymes and oxidative processes [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups

Liu

Shang

et al. 2020

Molecules

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Asari Radix et Rhizoma (ARR) is an important traditional Chinese medicine. Volatile organic compounds (VOCs) are the main active constituents of ARR. Research on the metabolite profile of VOCs and the difference of absorbed constituents in vivo after an administration of ARR decoction and powder will be helpful to understand the pharmacological activity and safety of ARR. In this study, headspace solid-phase microextraction gas chromatography mass spectrometry (HS–SPME–GC–MS) was applied to profile the VOCs from ARR in rats in vivo. A total of 153 VOCs were tentatively identified; 101 were original constituents of ARR (98 in the powder-treated group and 43 in the decoction-treated group) and 15 were metabolites, and their metabolic reactions were mainly oxidation and reduction, with only two cases of methylation and esterification, and 37 unclassified compounds were identified only in the ARR-treated group. Of the 153 VOCs identified, 131 were reported in rats after oral administration of ARR for the first time, containing 79 original constituents, 15 metabolites, and 37 unclassified compounds. In the powder-treated group, methyleugenol, safrole, 3,5-dimethoxytoluene (3,5-DMT), 2,3,5-trimethoxytoluene (2,3,5-TMT), and 3,4,5-trimethoxytoluene (3,4,5-TMT) were the main absorbed constituents, the relative contents of which were significantly higher compared to the decoction-treated group, especially methyleugenol, safrole, and 3,5-DMT. In the decoction-treated group, 3,4,5-TMT, 2,3,5-TMT, kakuol, and eugenol were the main constituents with a higher content and wider distribution. The results of this study provide a reference for evaluating the efficacy and safety of ARR.

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Section: Resultsmentioning

confidence: 99%

The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups

Liu

Shang

et al. 2020

Molecules

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“…We consider that the toxicity will emerge before its medicinal effects appear. Eugenol has been reported to show antioxidant activity [35]; however, the relationship between its activity and the Nrf2 pathway was not clear. In zebrafish larvae, eugenol did not show any antioxidant activity or toxic effects, even at 125 µM.…”

Section: Discussionmentioning

confidence: 99%

“…Since all phytochemicals used in this study were known to have antioxidant activity [30][31][32][33][34][35][36][37][38][39], we considered that almost all of the 10 phytochemicals would also exhibit antioxidant activity in zebrafish larvae. However, only five showed protective effects against H 2 O 2 toxicity, including isoeugenol and 6-MSITC, which showed only slight effects ( Figure 6, black triangles), in addition to curcumin, diallyl trisulfide and quercetin.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish

Endo

Muraki

Fuse

2020

IJMS

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Various dietary phytochemicals seem to display antioxidant activity through the NF-E2-related factor 2 (Nrf2) pathway. However, few studies have demonstrated its antioxidant effect and Nrf2 dependency at the animal level. We constructed a zebrafish-based assay system to analyze the in vivo antioxidant activity of phytochemicals and examined the activity of 10 phytochemicals derived from spices, using this system as a pilot study. Hydrogen peroxide and arsenite were used as oxidative stressors, and Nrf2 dependency was genetically analyzed using an Nrf2-mutant zebrafish line. The activities of curcumin, diallyl trisulfide and quercetin were involved in the reduction of hydrogen peroxide toxicity, while those of cinnamaldehyde, isoeugenol and 6-(methylsulfinyl)hexyl isothiocyanate were involved in the reduction of arsenite toxicity. The antioxidant activities of these phytochemicals were all Nrf2 dependent, with the exception of cinnamaldehyde, which showed strong antioxidant effects even in Nrf2-mutant zebrafish. In summary, we succeeded in constructing an assay system to evaluate the in vivo antioxidant activity of various phytochemicals using zebrafish larvae. Using this system, we found that each spice-derived phytochemical has its own specific property and mechanism of antioxidant action.

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“…It has a wide range of applications in food and cosmetic industry as flavor and antioxidant as well as in the traditional medicine [26,28,30]. Eugenol and its derivatives have also been reported to have potential activities as antiinflammatory, anti-tumor, antimicrobial, anti-pyretic, analgesic and anesthetic [31]. Its benzoate and 2nitrobenzoate derivatives as well as its synergistic effects with approved anti-TB drugs have been shown to exhibits strong activity against Mycobacterium spp.…”

Section: Introductionmentioning

confidence: 99%

“…and M. tuberculosis [32]. Its hydrazone derivatives were studied by molecular docking against the enoyl-ACP reductase as a molecular target and validated by in vitro assay which showed a docking score of −10.393 kcal/mol with minimum inhibitory activity at 25μg/ml [31,33].…”

Section: Introductionmentioning

confidence: 99%

Acetyleugenol from <em>Acacia nilotica</em> (L.) exhibits a strong antibacterial activity and its phenyl and indole analogs show a promising anti-TB potential

Abdulhamid¹,

Adlan²,

Ahmed³

et al. 2020

Preprint

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Acetyleugenol is a phytochemical compound with broad effect against infectious diseases and tumors. Here, we extracted, characterized and elucidated the structure of acetyeugenol, for the first time, from the leaves of Acacia nilotica (L.)―a well-known medicinal plant. The broad antibacterial potential of acetyleugenol was first confirmed against seven bacterial pathogenic isolates with best activity against Proteus sp., Salmonella typhi, Staphylococcu aureus, and Streptococcus pneumonia, which showed similar or better zone of inhibition to that of the control amoxicillin. To further investigate its effect against Mycobacterium tuberculosis, acetyleugenol and its indole and phenyl analogs were subjected to molecular docking experiments against two potential tuberculosis drug targets―MtPknE and MtPknB Ser/Thr protein kinases. The results reveal that all of the analogs have improved docking scores comparing to the acetyleugenol. The indole analogs EUG-1 and EUG-3 were more effective with better docking scores for MtPknE with –11.08 and –10.05 kcal/mol, respectively. Similar results were obtained for the MtPknB. In contrast, only the EUG-2 phenyl analog has given rise to similar docking scores for both targets. This opens the door for further comprehensive studies on these acetyleugenol analogs with in vitro and in vivo experiments to validate and get more insights into their mechanisms of action.

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An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol

Cited by 196 publications

References 63 publications

The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups

The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups

Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish

Acetyleugenol from <em>Acacia nilotica</em> (L.) exhibits a strong antibacterial activity and its phenyl and indole analogs show a promising anti-TB potential

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