Effect of 3-O-Octanoyl-(+)-catechin on the Responses of GABAA Receptors and Na+/Glucose Cotransporters Expressed in Xenopus Oocytes and on the Oocyte Membrane Potential

Aoshima, Hitoshi; Okita, Yoichi; Hossain, Sheikh Julfikar; Fukue, Keiko; Mito, Mariko; Orihara, Y.; Yokoyama, Terufumi; Yamada, Mamoru; Kumagai, Akira; Nagaoka, Yasuo; Uesato, Shinichi; Hara, Yukihiko

doi:10.1021/jf048492c

Cited by 25 publications

(11 citation statements)

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“…However, further in vitro and in vivo studies are needed to confirm the present observations. Attention should be paid to potential cytotoxic effects when they are used for the preparation of dietary supplements, and in the enrichment of beverages or foods, since some polyphenols perturb the membrane structure (Hossain et al, 2002;Aoshima et al, 2005). Moreover, fractionation of potential extracts is essential for determining the phenolic or nonphenolic compound(s) responsible for the antioxidative, antiamylase, anti-glucosidase, and anti-allergic activities.…”

Section: Resultsmentioning

confidence: 99%

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Hossain

Tsujiyama

Takasugi

et al. 2008

FSTR

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To seek out a cheap source of dietary polyphenols and antioxidants along with anti-amylase and antiglucosidase activities, ethanol extracts of eleven cheap Bangladeshi fruits were investigated. The extracts were also examined for anti-allergic activity using rat peritoneal exudate cells exposed to the calcium ionophore A23187. Phyllanthus emblica (emblic myrobalan) had the highest total polyphenol content (339 mg gallic acid equivalent (GAE)/g), followed by Syzygium cumini (Indian blackberry; 192.3 mg GAE/g), and Aegle marmelos (wood apple; 53.7 mg GAE/g). P. emblica, and S. cumini also exhibited the most potent DPPH radical scavenging activity, with an IC 50 of 2.1 and 8.6 μg/mL respectively. These extracts also showed promising reducing powers with P. emblica having the greatest such activity (optical density (O.D.) 1.66), followed by S. cumini (O.D. 1.34), at a concentration of 0.2 mg/mL. The extracts of Artocarpus heterophyllus (jackfruit) and S. cumini showed promising chelating activities. At a concentration of 1 mg/ mL, Dillenia indica (chalta) showed the highest inhibition of α-amylase activity (60%), and A. marmelos, D. indica, P. emblica, Spondias dulcis (hog-plum) & S. cumini completely inhibited α-glucosidase activity (100%). Apart from A. heterophyllus, D. indica and Phyllanthus acidus (star-gooseberry), all other extracts inhibited the release of histamine from the peritoneal exudate cells, with S. cumini having the strongest effect. These fruits therefore have activities beneficial to physiological health. Keywords: antioxidant, anti-amylase, anti-glucosidase, anti-allergy, antihistamine release, fruits, polyphenol *To whom correspondence should be addressed. Email: aoshima@yamaguchi-u.ac.jp IntroductionFruits are major sources of health promoting agents. Of these agents, antioxidants are most important because they inhibit the initiation of lipid peroxidation, which is related to aging and the pathogenesis of diseases such as cardiovascular disorders, cancer, inflammation, and brain dysfunction (Ames, 1983;Shon et al., 2004). Various epidemiological studies have suggested that consumption of fruit and vegetables is associated with reduced risk of cardiovascular diseases and cancers (Kris-Etherton et al., 2002), neurodegenerative diseases such as Parkinson's and Alzheimer's diseases (Di Matteo and Esposito, 2003), as well as with inflammation and aging (Ames et al., 1993).Natural products are reportedly beneficial to physiological health. Various flavonoids and non-flavonoids have been reported as showing radical scavenging activity (Sawa et al., 1999): flavone, and flavonoids inhibit α-amylase and α-glucosidase activities (Havsteen, 1983;Kim et al., 2000); polyphenols have anti-hyperglycemic effects (Hossain et al., 2002;Hanamura et al., 2006), and inhibit the development of diabetes (Zunimo et al., 2007). Since glucose release from food sources is the main factor affecting post-prandial hyperglycaemia, retardation of the digestion of starch by key gastrointestinal enzymes can be of benefit to...

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Section: Resultsmentioning

confidence: 99%

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Hossain

Tsujiyama

Takasugi

et al. 2008

FSTR

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“…Attention should be paid especially to P. turgidum and W. somnifera because of their high antioxidative activity in addition to considerable inhibition of α-amylase activity. It is necessary to elucidate potential cytotoxic effects when they are used for the preparation of dietary supplements, since some polyphenols perturb the membrane structure (Hossain et al, 2002;Aoshima et al, 2005). Moreover, fractionation of potential extracts is essential to know the phenolic or nonphenolic compound(s) responsible for the antioxidative and antiamylase activities.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative and anti-α-amylase activities of four wild plants consumed by pastoral nomads in Egypt

Hossain¹,

El‐Sayed²,

Aoshima³

2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYIn this study, four plants grown naturally in Egypt that are usually consumed by pastoral nomads were screened for their total phenolic contents, antioxidative, and anti-α-amylase activities. Dried powder of plant's part was extracted in absolute or 70% ethanol. A polar extract of Panicum turgidum (PTPE) had the highest total polyphenol content {92.5 mg gallic acid equivalents (GAE)/g}, followed by an alkaloid extract of Withania somnifera (WSAlk; 77.5 mg GAE/g), and an ethanol extract of Leptadenia pyrotechnica (LPEE; 59.1 mg GAE/g). By employing different assays such as DPPH radical scavenging, reducing power, Fescavenging and total antioxidant capacity, it was shown that PTPE, WSEE (ethanol extract of W. somnifera), WSAlk and LPEE had promising antioxidant activity, though, their potency varied according to the different tests. WSAlk had the highest level of α-amylase inhibition (40.2%) in vitro, followed by WSEE (30.5%). Therefore, it can be concluded that these plants, especially extracts of PTPE, and WSAlk are beneficial to physiological health, and could be used in food and pharmaceutical industries to prepare dietary supplements, functional foods or food preservatives.

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“…The purpose of the present study was to clarify the contribution of a chemical group in the catechin structure for the sedative properties using the chick social-separation stress model [16]. EGCG is capable of protecting against neuronal injury in living brain tissue [17], though EGCG damages membrane inducing cell toxicity in vitro [18]. The doses of EGCG used in Experiment 1 were considered neuroprotective [3].…”

Section: Discussionmentioning

confidence: 99%

Galloyl Group is not Necessary for a Sedative Effect of Catechin Through GABAergic System

Adachi

Tomonaga

Suenaga

et al. 2007

LDDD

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Epigallocatechin gallate (EGCG) has a sedative effect acting through γ-aminobutyric acid (GABA) A receptors in the brain, but it is unclear what structural components of the molecule are necessary for its action. To investigate the necessity of the galloyl group on the sedation induced by EGCG, the effect of EGCG was compared with (-)-epigallocatechin (EGC) in which the galloyl group is removed from EGCG. Intracerebroventricular (i.c.v.) injection of EGC, as well as EGCG, induced, and the effect of EGC were blocked by the GABA A receptor antagonist picrotoxin. It is concluded that catechins have a sedative effect acting through GABA A receptors under an acute stress condition irrespective of the presence of the galloyl group.

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Effect of 3-O-Octanoyl-(+)-catechin on the Responses of GABA_A Receptors and Na⁺/Glucose Cotransporters Expressed in Xenopus Oocytes and on the Oocyte Membrane Potential

Cited by 25 publications

References 20 publications

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Antioxidative and anti-α-amylase activities of four wild plants consumed by pastoral nomads in Egypt

Galloyl Group is not Necessary for a Sedative Effect of Catechin Through GABAergic System

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