Effect of 24 hour application of three hemostatic dressings to porcine thigh muscles

Adamiak, Z.; Jastrzębski, Paweł; Pomianowski, A.; Otrocka-Domagała, Iwona; Holak, Piotr; Zhalniarovich, Y.; Przyborowska, P.; Głodek, Joanna

doi:10.2478/pjvs-2014-0076

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…Chitosan-based hemostatic dressings were also effectively used in rats [5,7] . The application of hemostatic dressings in pigs was more extensively researched [8][9][10] . Kozen et al [4] reported that Celox Gauze was as effective as two other hemostatic dressings, and it significantly improved survival rates in comparison with standard dressings.…”

Section: Letter To the Editormentioning

confidence: 99%

Two Cases of Celox Gauze Application to Control Bleeding from the Canine Popliteal Artery

Adamiak¹,

Bski²,

Odek³

et al. 2020

Kafkas Univ Vet Fak Derg

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Section: Letter To the Editormentioning

confidence: 99%

Two Cases of Celox Gauze Application to Control Bleeding from the Canine Popliteal Artery

Adamiak¹,

Bski²,

Odek³

et al. 2020

Kafkas Univ Vet Fak Derg

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“…In an emergency setting, damaged vessels are often treated with hemostatic dressings, which are left in the wound site until surgical repair [1]. Global rescue standards, including Trauma Life Support and Tactical Combat Causality Care, include detailed guidelines for using hemostatic dressings.…”

Section: Introductionmentioning

confidence: 99%

The effect of hemostatic dressing prototypes for the uniformed services on selected blood coagulation parameters in pigs

et al. 2017

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BackgroundSerious injuries accompanied by severe bleeding are life-threatening. Post-traumatic hemorrhage involves the risk of developing coagulopathy. Hemostatic dressings are widely used to minimize bleeding. The application of procoagulants in control of hemorrhage may lead to thrombosis or disseminated intravascular coagulation. The aim of this study was to evaluate the effect of hemostatic dressing prototypes on the porcine coagulation system.ResultsFibrinogen and d-dimer concentrations were significantly higher in the experimental groups where hemostatic dressings were used in comparison with the control group. Considerable differences in antithrombin III activity and thrombin–antithrombin complex concentrations were also observed between groups.ConclusionsThe hemostatic dressing comprising modified seton impregnated with 18.0 g/m2 of procoagulant was most effective in preserving the physiological equilibrium between fibrinogenesis and fibrinolysis.

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“…In the process of developing new types of haemostatic dressings, the selection of procoagulants of optimal quality and with a concentration that can effectively control bleeding and prevent DIC and thrombosis, is a significant challenge. Scientists continue to search for the ideal haemostatic dressing that would effectively manage massive bleeding without exerting adverse effects on human and animal haemostasis (9).…”

mentioning

confidence: 99%

The Effect of Haemostatic Dressing Prototypes for the Emergency Services in the Porcine Haemostatic System

Adamiak

Borys²,

Krystkiewicz

et al. 2019

In Vivo

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Background/Aim: Coagulopathy can develop when hemostatic dressings are used to stop massive bleeding, even in patients without prior history of clotting disorders. The selection of procoagulants, which effectively control bleeding and prevent disseminated intravascular coagulation (DIC) and thrombosis, is a significant challenge. The aim of this study was to evaluate the effect of two prototypes of haemostatic dressing in the porcine haemostatic system. Materials and Methods: The total number of animals used in our experiments was 24. Group I: pigs were treated with the developed prototype of sponge dressing, made of Na-Ca chitosan/algal composite of microfibers and nanofibers. Group II: animals were treated with a seton gauze modified with a polymer mixture of Na-Ca chitosan/algal composite of microfibers and nanofibers. Group III: animals were treated with non-hemostatic dressing and this group was the control. Blood was sampled five times to determine changes in the coagulation and fibrinolytic profiles: before injury: i) at 1 h, ii) at 24 h, iii) at 7, and iv) at 14 days following injury. Results: Significant changes were observed in the coagulation parameters, in the total numbers of white blood cells and platelets in groups I and II, compared to controls. Conclusion: The modified haemostatic dressings used in this study produced a strong procoagulant effect in pigs. This, together with high fibrinogen concentrations, which can cause DIC, require further studying.

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Effect of 24 hour application of three hemostatic dressings to porcine thigh muscles

Cited by 7 publications

References 6 publications

Two Cases of Celox Gauze Application to Control Bleeding from the Canine Popliteal Artery

Two Cases of Celox Gauze Application to Control Bleeding from the Canine Popliteal Artery

The effect of hemostatic dressing prototypes for the uniformed services on selected blood coagulation parameters in pigs

The Effect of Haemostatic Dressing Prototypes for the Emergency Services in the Porcine Haemostatic System

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