Effect of 2-hydroxy-4-methylselenobutanoic acid as a dietary selenium supplement to improve the selenium concentration of table eggs1

Abstract

The aim of this study was to compare the effects of a new organic Se [2-hydroxy-4-methylselenobutanoic acid (HMSeBA)] with routinely used mineral and organic Se sources (sodium selenite and selenized yeast) on chosen performance criteria and Se deposition in egg and muscle of laying hens. A total of 240 laying hens (40 wk of age) were randomly assigned to 6 treatments for 56 d with 8 replicates of 5 hens per replicate. The 6 treatments were as follows: control group received basal diet without Se supplementation; the second, fourth, and sixth experimental groups (SS-0.2, SY-0.2, and HMSeBA-0.2, respectively) were fed basal diet supplemented with Se at 0.2 mg/kg from sodium selenite, selenized yeast, and HMSeBA, respectively; and the third and fifth experimental groups (SY-0.1, and HMSeBA-0.1, respectively) were fed basal diet supplemented with Se at 0.1 mg/kg from selenized yeast and HMSeBA, respectively. No difference was observed among dietary treatments on feed intake, egg weight, and laying rate. All hens fed the Se-supplemented diets exhibited greater total Se contents in their eggs compared with control hens (P < 0.01). The egg Se concentrations were greater in hens fed organic Se (HMSeBA-0.2, P < 0.01, and SY-0.2, P < 0.01) than those fed the SS-0.2. In addition, hens fed the diet with HMSeBA-0.2 accumulated more Se in their eggs (+28.78%; P < 0.01) and muscles (+28%; P < 0.01) than those fed the diet supplemented with SY-0.2. These results showed the greater ability of HMSeBA to increase Se deposition in eggs and breast muscle of laying hens, which can subsequently lead to greater supply of Se for humans.

The influence of selenium and selenoproteins on immune responses of poultry and pigs

“…elderly people > 65 years (Thane and Bates, 2001). Several reports show the possibility of increasing the Se content in table eggs by supplementing the layer diet with organic Se additive Fisinin et al, 2009;Bennett and Cheng, 2010;Jlali et al, 2013).…”

“…In addition, the organic Se source hydroxy-selenomethionine, (2-hydroxy-4methylselenobutanoic acid or HMSeBA) when supplementated to growing pigs showed a higher deposition of Se in muscle compared to selenized yeast (Jlali et al, 2014). Likewise, in laying hens, the provision of HMSeBA increased Se deposition in eggs and breast muscle compared with other Se sources (sodium selenite and selenized yeast) (Jlali et al, 2013).…”

Organic trace minerals on productive performance, egg quality and immune response in Bovans White laying hens

“…Organic trace minerals (OTM) have higher bioavailability than ITM, since they take advantage of alternative absorption routes, provides protection towards mineral antagonisms and against indigestible complexes formation (Saripinar‐Aksu, Aksu, & Önel, ). Although OTM commonly do not produce sensible effects on productive performance (Jlali et al, ; Maciel et al, ; Manangi, Vazquez‐Añon, Richards, Carter, & Knight, ; Stefanello, Santos, Murakami, Martins, & Carneiro, ), a reduction in its inclusion levels does not compromise productive performance on commercial birds (Gheisari, Sanei, Samie, Gheisari, & Toghyani, ; Stefanello et al, ), and this represent less faecal excretion minimizing its deposition in the environment (Bao, Choct, Iji, & Bruerton, ; Yenice, Mizrak, Gültekin, Atik, & Tunca, ). The addition of OTM improvements is reported in shell quality associated with changes in ultrastructure (Gheisari et al, ; Manangi et al, ; Stefanello et al, ; Światkiewicz & Koreleski, ), lower loss of Haugh units (HU) by storage (Sun, Guo, Li, Zhang, & Wen, ), as well as increased concentrations of Tm in eggs and shells (Jlali et al, ; Sun et al, ; Yenice et al, ).…”

“…Although OTM commonly do not produce sensible effects on productive performance (Jlali et al, ; Maciel et al, ; Manangi, Vazquez‐Añon, Richards, Carter, & Knight, ; Stefanello, Santos, Murakami, Martins, & Carneiro, ), a reduction in its inclusion levels does not compromise productive performance on commercial birds (Gheisari, Sanei, Samie, Gheisari, & Toghyani, ; Stefanello et al, ), and this represent less faecal excretion minimizing its deposition in the environment (Bao, Choct, Iji, & Bruerton, ; Yenice, Mizrak, Gültekin, Atik, & Tunca, ). The addition of OTM improvements is reported in shell quality associated with changes in ultrastructure (Gheisari et al, ; Manangi et al, ; Stefanello et al, ; Światkiewicz & Koreleski, ), lower loss of Haugh units (HU) by storage (Sun, Guo, Li, Zhang, & Wen, ), as well as increased concentrations of Tm in eggs and shells (Jlali et al, ; Sun et al, ; Yenice et al, ). Besides, positive effects have been observed on the bone mineralization (Gheisari et al, ; Manangi et al, ), Tm levels in serum (Yenice et al, ), retention in organs (Jlali et al, ; Sun et al, ) and in the activity of some enzymes (Sun et al, ).…”

“…The addition of OTM improvements is reported in shell quality associated with changes in ultrastructure (Gheisari et al, ; Manangi et al, ; Stefanello et al, ; Światkiewicz & Koreleski, ), lower loss of Haugh units (HU) by storage (Sun, Guo, Li, Zhang, & Wen, ), as well as increased concentrations of Tm in eggs and shells (Jlali et al, ; Sun et al, ; Yenice et al, ). Besides, positive effects have been observed on the bone mineralization (Gheisari et al, ; Manangi et al, ), Tm levels in serum (Yenice et al, ), retention in organs (Jlali et al, ; Sun et al, ) and in the activity of some enzymes (Sun et al, ). In respect of immune response, the inclusion of organic Se and Zn has been shown to improve the enzymatic activity against free radicals (Boostani, Sadeghi, Mousavi, Chamani, & Kashan, ; Saad, Gertner, Bona, & Santin, ), the antibody titres (Feng et al, ; Manangi et al, ; Silva et al, ), the size of lymphoid organs (Feng et al, ) and the cellular immune response (Moghaddam & Jahanian, ).…”