Effect of 2,4-dichlorophenoxyacetic acid on the in vivo metabolism of acetone in adult rats

Effect of 2,4-D on incorporation of carbon-14 into urinary metabolites from rats receiving carbon-14-labeled acetate

“…Besides comparing the fluctuation of the minor metabolites, it is also of special interest to compare the 2,4-Dtreated rats with the controls in other respects. In 2,4-Dtreated female rats given acetate-1-14C, the percentage of labeling in the urine actually increased over that of the controls (Philleo and Fang, 1967). This increase of some 4.5% is thought to be significant, because the values were taken from work with several different rats and many experiments, and in every case this slight increase was noted.…”

“…The effect of 2,4-D on the elimination pattern of respiratory 14C02 from labeled acetate has been reported (Philleo and Fang, 1967). This paper reports a study on the labeling patterns of urinary metabolites from control and 2,4-D-treated rats receiving labeled acetate.…”

“…Both 2,4-D (100 mg. per rat) and acetate-14C were orally administered to the rats by means of a stomach tube as described by Philleo and Fang (1967). After the acétatele was administered, the rat was placed in a Delmar metabolism cage with an excess of food and water.…”