Effect of 17β-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice

Islamov, R. R.; Hendricks, Wesley A.; Katwa, Laxmansa C.; McMurray, Roger J.; Pak, Elena S.; Spanier, Nicole S.; Murashov, Alexander K.

doi:10.1016/s0006-8993(02)04191-4

Cited by 45 publications

(34 citation statements)

References 42 publications

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“…Their results have demonstrated that estrogen promotes regeneration of the sciatic nerve after crush injury. The data of Islamov et al (2003) suggest that estrogen could be one of the critical factors regulating transcription of genes involved in nerve regeneration and also estrogen promotes regeneration locally. In another study it is shown that after injury of sciatic nerve, estrogen suppresses the scar reaction (Nachemson et al 1985).…”

Section: Discussionmentioning

confidence: 99%

“…Strong biological evidence supports the benefits of estrogens in several experimental models of neurodegeneration (GarciaSegura et al 2001). Beneficial effects of estrogens in peripheral nervous system are also shown in several studies (Islamov et al 2002;Islamov et al 2003;Nachemson et al 1985). Although insulin is known to regulate the activity of aromatase (Garzo and Dorrington 1984;Nestler 1993) there is no data about the immunoreactivity levels of this enzyme in diabetes and also the levels of aromatase in hippocampus and sciatic nerves of diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes Alters Aromatase Enzyme Levels in Sciatic Nerve and Hippocampus Tissues of Rats

2009

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Diabetes mellitus (DM) is associated with increased risk of impaired cognitive function. Diabetic neuropathy is one of the most common and important complications of DM. Estrogens prevent neuronal loss in experimental models of neurodegeneration and accelerate nerve regeneration. Aromatase catalyzes the conversion of androgens to estrogens and expressed in a variety of tissues including neurons. Although insulin is known to regulate the activity of aromatase there is no study about the effects of diabetes on this enzyme. Present study was designed to investigate the effects of experimental diabetes on aromatase expression in nervous system. Gender-based differences were also investigated. Rats were injected with streptozotocin to induce diabetes. At the end of 4 and 12 weeks sciatic nerve and hippocampus homogenates were prepared and evaluated for aromatase proteins. Aromatase expressions in sciatic nerves of both genders were decreased in 4 weeks of diabetes, but in 12 weeks the enzyme levels were increased in females and reached to control levels in male animals. Aromatase levels were not altered in hippocampus at 4 weeks but increased at 12 weeks in female diabetic rats. No significant differences were observed at enzyme levels of hippocampus in male diabetic rats. Insulin therapy prevented all diabetes-induced changes. In conclusion, these results indicated for the first time that, DM altered the expression of aromatase both in central and peripheral nervous systems. Peripheral nervous system is more vulnerable to damage than central nervous system in diabetes. These effects of diabetes differ with gender and compensatory neuroprotective mechanisms are more efficient in female rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diabetes Alters Aromatase Enzyme Levels in Sciatic Nerve and Hippocampus Tissues of Rats

2009

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“…In the peripheral nervous system, estrogen receptors are found in the spinal cord [12][13][14][15], dorsal root ganglia [16][17][18][19], autonomic pelvic ganglia [14,15], sympathetic ganglia [20,21], and Schwann cells [22]. Numerous studies have shown that estrogens affect the nervous system via both genomic and non-genomic mechanisms, including the development, proliferation, and regeneration of neuronal cells, gene expression, energy metabolism, hormone sensitivity, and the biosynthesis of structural proteins and enzymes [12,15,17,19,23]. The hormonal changes that accompany menopause (i.e., decreased estrogen levels) have a significant impact on the nervous system and other physiological systems.…”

Section: Discussionmentioning

confidence: 99%

Carpal tunnel syndrome in postmenopausal women

Kaplan

Kurt

Karaer

2008

Journal of the Neurological Sciences

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“…Although ERb has not been directly assessed in the sciatic nerves of adult animals, its expression is very low in Schwann cells cultured from sciatic nerves of neonatal rats [61]. However, the expression of ERb is increased in motor neurons of the spinal cord after sciatic nerve injury [62], and may therefore be involved in the mechanisms of nerve regeneration. Another possible pathway mediating the effect of 3a-diol could be the interaction with GABA-A receptor [63,64], which is present both in sciatic nerve and in Schwann cells [65].…”

Section: Discussionmentioning

confidence: 99%

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

Roglio

Bianchi

Giatti

et al. 2007

Cell. Mol. Life Sci.

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Effect of 17β-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice

Cited by 45 publications

References 42 publications

Diabetes Alters Aromatase Enzyme Levels in Sciatic Nerve and Hippocampus Tissues of Rats

Diabetes Alters Aromatase Enzyme Levels in Sciatic Nerve and Hippocampus Tissues of Rats

Carpal tunnel syndrome in postmenopausal women

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

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