Effect of 11C-Methionine-Positron Emission Tomography on Gross Tumor Volume Delineation in Stereotactic Radiotherapy of Skull Base Meningiomas

Respiratory gated [18F]FDG PET/CT for target volume delineation in stereotactic radiation treatment of liver metastases

“…Thus, it has become a true option and is being perused in prospective clinical trials. In brain tumors, amino acid PET was found to reduce the interobserver variability and to improve the differentiation between active tumor and scar tissue in patients with previous surgery [6]. Similar results were found in glomus tumors [7].…”

“…The first method showed reliable and reproducible results for lesions in the lung [11], the brain [6], or in cancer of the head and neck [7,8]. For this purpose, a calibration with appropriate lesion size and activity concentrations for the lesions and the background must be performed for the individual acquisition setting.…”

In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1

“…[27][28][29] Tumoral accumulation of any of these amino acid tracers can occur as a result of tumoral transport, in which high LAT1 expression may play a central role. While tumoral metabolism of methionine can reflect protein synthesis, along with other metabolic pathways, FET and AMT are not incorporated in proteins.…”

Usefulness of L-[Methyl-¹¹C]Methionine Positron Emission Tomography in the Treatment of Idiopathic Hypertrophic Cranial Pachymeningitis

“…11 C-MET uptake shows variable increase in meningiomas that are hypo-or isometabolic on [ 18 F]FDG PET. 1,2) Similarly, the uptake of 11 C-MET is increased in granulomatous lesions and pachymeningitis that are hyper-or isometabolic on [ 18 F]FDG PET. 3,11) We emphasize the necessity for considering IHCP in the differential diagnosis of meningiomas.…”