Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice

Wang, Kai; Lu, Jing; Xing, Zhen-He; Zhao, Qi; Hu, Lin-Qi; Xue, Lei; Zhang, Jie; Mei, Yan‐Ai

doi:10.1038/srep44521

Cited by 25 publications

(27 citation statements)

References 37 publications

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“…The 1.8 GHz RF‐exposure system for live animals was made by East China Normal University (Shanghai, China), which was described elsewhere [Wang et al, ]. Briefly, the system had an RF signal source, a control system, and a movable loading platform.…”

Section: Methodsmentioning

confidence: 99%

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Guo

Zhang

et al. 2018

Bioelectromagnetics

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To investigate the effects of 1.8 GHz radiofrequency (RF) field on bone microstructure and metabolism of femur in mice, C57BL/6 mice (male, age 4 weeks) were whole-body exposed or sham exposed to 1.8 GHz RF field. Specific absorption rates of whole body and bone were approximately 2.70 and 1.14 W/kg (6 h/day for 28 days). After exposure, microstructure and morphology of femur were observed by microcomputed tomography (micro-CT), Hematoxylin and Eosin (HE) and Masson staining. Subsequently, bone parameters were calculated directly from the reconstructed images, including structure model index, bone mineral density, trabecular bone volume/total volume, connectivity density, trabecular number, trabecular thickness, and trabecular separation. Biomarkers that reflect bone metabolism, such as serum total alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase 5b (TRACP-5b), were determined by biochemical assay methods. Micro-CT and histology results showed that there was no significant change in bone microstructure and the above parameters in RF group, compared with sham group. The activity of serum ALP and BALP increased 29.47% and 16.82%, respectively, in RF group, compared with sham group (P < 0.05). In addition, there were no significant differences in the activity of serum TRACP-5b between RF group and sham group. In brief, under present experimental conditions, we did not find support for an effect of 1.8 GHz RF field on bone microstructure; however, it might promote metabolic function of osteoblasts in mice. Bioelectromagnetics. 39:386-393, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Methodsmentioning

confidence: 99%

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Guo

Zhang

et al. 2018

Bioelectromagnetics

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“…The 1.8 GHz RF exposure system (East China Normal University, Shanghai, China), which has been described elsewhere [ 10 ], is comprised of a RF signal source, a movable loading platform and a computer. The mice in the exposure group were placed freely in a plastic box with bedding (35 × 24 × 24 cm with small ventilation holes on the walls).…”

Section: Methodsmentioning

confidence: 99%

“…The power density in this study was 530 μW/cm 2 , as measured by an electromagnetic field meter (PMM8053A, PMM Costruzioni Electtroniche Centro Misure Radio Electriche S.r.l., Milan, Italy). A dosimetry assessment similar to that of a previous report [ 10 ] was used in this study. Briefly, the average SARs of whole body and brain were calculated using XFDTD7.2.3 (Remcom Inc., State College, PA, USA) and the reference electric constants of the tissues were derived from .…”

Section: Methodsmentioning

confidence: 99%

“…In terms of the effects of RF field on brain function, Wang found that although single exposure to 1800 MHz RF field for 30 min with specific absorption rates (SARs) in brain at 2.42, 2.86 and 3.3 W/kg did not affect spontaneous locomotor activity, it increased recognition memory in mice [ 10 ]. In addition, Bouji reported that after exposing the heads of the animals to 900 MHz RF field for 1 month (SAR 6 W/kg, 45 min/day), the spatial memory, emotional memory and locomotor activity did not change, but the anxiety-related behavior decreased in male senescent rats [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Zhang

Guo

et al. 2017

IJERPH

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The increasing use of mobile phones by teenagers has raised concern about the cognitive effects of radiofrequency (RF) fields. In this study, we investigated the effects of 4-week exposure to a 1.8 GHz RF field on the emotional behavior and spatial memory of adolescent male mice. Anxiety-like behavior was evaluated by open field test (OFT) and elevated plus maze (EPM) test, while depression-like behavior was evaluated by sucrose preference test (SPT), tail suspension test (TST) and forced swim test (FST). The spatial learning and memory ability were evaluated by Morris water maze (MWM) experiments. The levels of amino acid neurotransmitters were determined by liquid chromatography-mass spectrometry (LC-MS). The histology of the brain was examined by hematoxylin-eosin (HE) staining. It was found that the depression-like behavior, spatial memory ability and histology of the brain did not change obviously after RF exposure. However, the anxiety-like behavior increased in mice, while, the levels of γ-aminobutyric acid (GABA) and aspartic acid (Asp) in cortex and hippocampus significantly decreased after RF exposure. These data suggested that RF exposure under these conditions do not affect the depression-like behavior, spatial memory and brain histology in adolescent male mice, but it may however increase the level of anxiety, and GABA and Asp were probably involved in this effect.

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“…A “recognition index” is thus calculated as a percentage of time the rodent explores the new object compared with the familiar one. 53 …”

Section: Behavioral Tests Of Learning and Memory In Rodentsmentioning

confidence: 99%

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

Wahl¹,

Coogan²,

Solon-Biet³

et al. 2017

CIA

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Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients. Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.

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Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice

Cited by 25 publications

References 37 publications

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

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