Effect and mechanism of oyster hydrolytic peptides on spatial learning and memory in mice

Wang, Xueqin; Yu, Huahua; Xing, Ronge; Liu, Song; Chen, Xiaolin; Li, Pengcheng

doi:10.1039/c7ra13139a

Cited by 26 publications

(19 citation statements)

References 67 publications

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“…However, no significant differences (P >0.05) in heart and brain indexes were observed between groups. These results are in agreement with those of Wang et al (2018) who observed that oral administration of oyster protein hydrolysates had no significant differences in brain and spleen indexes compared with D-Galactose model mice. Additionally, Li et al (2012) reported that oral administration of Lb.…”

Section: Resultssupporting

confidence: 93%

“…Whereas, the oral administration of high dose synthetic peptide significantly (P ˂ 0.01) increased the GSH-PX activity in heart and brain tissues and no significant (P > 0.01) effect was found in GSH-PX activity in liver and whole blood. These results are in line with Peng et al (2014) and Wang et al (2018) who reported that oral administrations of whey protein hydrolysates and oyster protein hydrolysates have significantly increased the activity of GSH-PX in tissues and serum in D-galactose model. In this context, Hamad et al (2011) reported higher GSH-PX activity in rat after oral administration of whey protein hydrolysate compared to unhydrolysed whey protein.…”

Section: Effect Of Oral Administration Of Synthetic Peptide On Oxidatsupporting

confidence: 91%

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Effect of Peptides Synthesized From Lactoferrin of Buffalo Milk on Oxidative Stress in Kunming Mice

2020

THE JAPS

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Oxidative stress plays an important role in the pathogenesis of lifestyle-related diseases. Lactoferrin antioxidant peptide sequence SVDGKEDLIW has been purified from buffalo milk protein and then synthesized by solid phase synthesis. The antioxidant activity of the synthetic peptide was evaluated in D-Galactose treated Kunming mice. The experiment design included 35 mice that randomly divided into 5 groups named, normal group, G-Galatose model group, D-Galactose + low dose of synthetic peptide (0.1 g/kg body weight), D-Galactose + high dose of synthetic peptide (0.6g/kg body weight) and D-Galctose + vitamin C. After 6 weeks, mice were sacrificed and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) in blood, heart, liver and brain of mice were measured. The mice group of high-dose peptide showed significantly (P<0.01) higher liver index (5.89) than that of D-Galactose model group (4.41). The highest SOD activity values of heart, liver, brain and blood were obtained in low-dose synthetic peptide group (212.33, 404.88, 296.26 "U/mg protein" and 28.15 "U/g protein", respectively). Similarly, low-dose synthetic peptide group showed significantly (P<0.05) higher values of GSH-PX activity. Whereas, MDA contents in heart and whole blood (0.35 and 25.24 "nmol/mg protein", respectively) were significantly (P<0.05) decreased in the low-dose peptide group. This study emphasizes the antioxidant activity of SVDGKEDLIW in vivo and demonstrates a promising antioxidant capacity of the synthetic peptide derived from lactoferrin of buffalo milk.

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Section: Resultssupporting

confidence: 93%

Section: Effect Of Oral Administration Of Synthetic Peptide On Oxidatsupporting

confidence: 91%

Effect of Peptides Synthesized From Lactoferrin of Buffalo Milk on Oxidative Stress in Kunming Mice

2020

THE JAPS

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“…Although the dietary supplementation of walnuts has been proven to improve memory deficits and learning skills in transgenic mice models, many researchers still pay more attention to walnut oils, which are considered to be rich in polyunsaturated fatty acids with a strong neuroprotective effect [ 11 , 12 ]. In recent years, it has been found that the peptides from different kinds of protein hydrolysates possessed potential bioactivities, such as hazelnut peptides against oxidative stress, and oyster peptides, which improved learning and memory of mice [ 13 , 14 ]. Moreover, gastrointestinal digestion has been suggested as an effective pathway to produce bioactive peptides, which have been used to prepare bioactive peptides from chicken breast and rapeseed proteins [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Walnut Protein Hydrolysates Play a Protective Role on Neurotoxicity Induced by d-Galactose and Aluminum Chloride in Mice

et al. 2018

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In recent years, with an increase in the aging population, neurodegenerative diseases have attracted more and more attention. This study aimed to investigate the potential neuroprotective effect of defatted walnut meal protein hydrolysates (DWMPH) on neurotoxicity induced by d-galactose (d-gal) and aluminum chloride (AlCl3) in mice. The animal models were established by combining treatments with d-gal (200 mg/kg/day, subcutaneously) and AlCl3 (100 mg/kg in drinking water) for 90 days. During the 90 days, 1 g/kg of DWMPH was administrated orally every day. The results indicated that DWMPH treatment alleviated oxidative stress, reversed cholinergic dysfunction, and suppressed the release of proinflammatory cytokines in the brains of d-gal + AlCl3-treated mice, and thus improving the learning and memory functions of these mice, which was closely correlated with the strong antioxidant activity of DWMPH. This finding suggests that DWMPH might be a promising dietary supplement in improving neuronal dysfunctions of the brain.

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“…Syouji et al [30] reported an increase in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampal formation by CH in vitro, and a significant increase in passive avoidance learning. In another study, the oral administration of oyster hydrolytic peptides in normal mice enhanced their spatial learning and memory capacity, accompanied by the upregulated expression of BDNF and neural cell adhesion molecules [31]. These findings in animal models suggest that the ingestion of CH might contribute to the change of brain structure and improvement in language cognitive function through the upregulation of BDNF expression in the brain.…”

Section: Discussionmentioning

confidence: 88%

Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study

Koizumi¹,

Inoue²,

Sugihara³

et al. 2019

Nutrients

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This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49–63 years. The primary outcome measures were the brain healthcare quotients based on gray matter volume (GM-BHQ) and fractional anisotropy (FA-BHQ). The secondary outcome measures were changes in scores between week 0 and week 4 for word list memory (WLM) and standard verbal paired associate learning (S-PA) tests as well as changes in the physical, mental, and role/social component summary scores of the Short Form-36(SF-36) quality of life instrument. CH ingestion resulted in significant improvements in FA-BHQ (p = 0.0095), a measure of brain structure, as well in scores for the WLM (p = 0.0046) and S-PA (p = 0.0007) tests, which measure cognitive function. There were moderate correlations between the change in WLM score and the change in GM-BHQ (r = 0.4448; Spearman’s rank correlation) and between the change in S-PA score and the change in FA-BHQ (r = 0.4645). Daily ingestion of CH changed brain structure and improved language cognitive function.

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Effect and mechanism of oyster hydrolytic peptides on spatial learning and memory in mice

Abstract: Oyster protein hydrolysate could be a functional food candidate to improve learning and memory ability.

Cited by 26 publications

References 67 publications

Effect of Peptides Synthesized From Lactoferrin of Buffalo Milk on Oxidative Stress in Kunming Mice

Effect of Peptides Synthesized From Lactoferrin of Buffalo Milk on Oxidative Stress in Kunming Mice

Walnut Protein Hydrolysates Play a Protective Role on Neurotoxicity Induced by d-Galactose and Aluminum Chloride in Mice

Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study

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