EFEKTIVITAS TANAMAN PEPAYA (Carica papaya L.) TERHADAP PENYEMBUHAN LUKA : A NARRATIVE REVIEW

Syah, Adam; Dianita, Puspita Septie; Agusta, Herma Fanani

doi:10.47653/farm.v9i1.540

Cited by 4 publications

(6 citation statements)

References 4 publications

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“…This chemical is distinguished by the presence of many phenol groups in its molecule. Since polyphenols are polar, polar solvents can extract these chemicals [20], [21]. Polyphenols contribute to plant pigmentation, such as leaf color.…”

Section: Determination Of Phenol Contentmentioning

confidence: 99%

Antibacterial Activity and Determination of Total Phenol and Flavonoid of Carica papaya L. Ethanol Extract

Karo-Karo

Arianto

Salim

2023

International Journal of Science, Technology & Management

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Infectious diseases are Indonesia's most common. Antibiotics are used to treat infections. Medicine needs new antibiotics due to antibiotic resistance. Antibiotics from plants are possible. Papaya leaf carpain alkaloids may be antibacterial. This study determined papaya leaf compound content, flavonoids' total phenol content, and the optimal concentration of papaya leaf ethanol extract that inhibits Staphylococcus aureus and Pseudomonas aeruginosa. The first stages of the research were the maceration of papaya leaf extract with 96% ethanol solvent, the phytochemical screening test (alkaloid, flavonoid, saponin, tannin, and steroid and triterpenoid tests), total phenol and total flavonoids tests, and the paper disc antibacterial activity test. Alkaloids, flavonoids, glycosides, tannins, steroids, and saponins were found in papaya leaf ethanol extract. Papaya leaf ethanol extract has 59.05 mgQE/g flavonoids and 56.80 GAE/g phenols. The antibacterial activity test of papaya leaf ethanol extract measured the diameter of the inhibitory zone on Staphylococcus aureus and Pseudomonas aeruginosa. Alkaloids, flavonoids, glycosides, tannins, steroids, and saponins were found in papaya leaf ethanol extract. Papaya leaf ethanol extract has 59.05 mgQE/g flavonoids and 56.80 GAE/g phenols. Papaya leaf ethanol extract had the best inhibition zone diameter for Staphylococcus aureus at 150 mg/mL (12.85 mm) and Pseudomonas aeruginosa at 150 mg/mL (13.10 mm).

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Section: Determination Of Phenol Contentmentioning

confidence: 99%

Antibacterial Activity and Determination of Total Phenol and Flavonoid of Carica papaya L. Ethanol Extract

Karo-Karo

Arianto

Salim

2023

International Journal of Science, Technology & Management

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“…Dari data di atas, terlihat bahwa nilai signigfikansi uji Wilcoxon data pre dan post perlakuan adalah 0,00 yaitu <0,05 sehingga dapat ditarik kesimpulan bahwa terdapat perbedaan yang signifikan antara panjang luka sayat sebelum dan setelah diberikan perlakuan pada kelinci. Hal ini disebabkan karena daun pepaya memiliki efek mempercepat penyembuhan luka darena adanya kandungan senyawa organik berupa saponin, flavonoid dan enzim papain yang berperan terhadap proses penyembuhan luka (Syah et al, 2022). Dari data diatas, terlihat bahwa data yang terdistribusi normal (Sig = > 0,05) adalah basis dan F1 saja sedangkan kelompok lain tidak terdistribusi normal dan homogen (p=0,000).…”

Section: Hasil Pengamatan Penyembuhan Lukaunclassified

“…Berdasarkan hasil uji statistik menunjukkan bahwa ekstrak pepaya berpengaruh nyata (p≤0,05) terhadap proses penyembuhan luka iris mulut pada mencit (Hakim, 2019). Syah et al, (2022) melakukan review 10 jurnal mengenai kandungan dan efek dari tanaman papaya terhadap penyembuhan luka. Data dalam review menunjukkan bahwa pemberian tanaman pepaya (Carica papaya L.) yang meliputi bagian getah, batang, biji, dan daun mempunyai efektivitas yang baik terhadap proses penyembuhan luka dan memiliki aktivitas antibakteri penyebab infeksi luka.…”

Section: Hasil Pengamatan Penyembuhan Lukaunclassified

POTENSI GEL EKSTRAK DAUN PEPAYA (Carica papaya L.) SEBAGAI PENYEMBUH LUKA SAYAT PADA KELINCI

Januarti,

Komalasari,

Sholeh

2023

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Luka adalah terputusnya kontinuitas jaringan akibat substansi jaringan yang rusak atau hilang sehingga dapat menyebabkan kerusakan fungsi perlindungan kulit dan dapat disertai dengan kerusakan jaringan lain. Ekstrak daun pepaya merupakan salah satu alternatif untuk dapat mempercepat pembentukan epitel luka. Hal ini dikarenakan pada daun pepaya terdapat saponin yang merupakan senyawa yang dapat memacu pembentukan suatu kolagen dalam proses penyembuhan luka. Penelitian ini bertujuan Menentukan konsentrasi ekstrak daun pepaya dalam sediaan gel yang efektif terhadap penyembuhan luka sayat pada kelinci. Penelitian ini dianalisis dengan statistik non parametrik menggunakan Wilcoxon, Kruskall Wallis dilanjutkan dengan uji lanjut Mann Whitney. Metode yang digunakan dalam penelitian ini adalah prepost design. Penelitian ini terdiri dari 5 perlakuan, yaitu 1 kontrol positif (Bioplacenton®), 1 kontrol negatif (tanpa pengobatan), basis gel dan 3 konsentrasi bertingkat yaitu gel ekstrak konsentrasi 5%, gel ekstrak konsentrasi 10% dan gel ekstrak konsentrasi 15% dengan masing-masing 5 kali pengulangan. Perlakuan dilakukan sebanyak dua kali dalam sehari selama 13 hari. Hasil Pengukuran Panjang Luka pada kelinci berdasarkan hasil penelitian menunjukkan bahwa gel ekstrak daun papaya memiliki potensi sebagai penyembuh luka sayat pada kelinci dengan nilai P-Value <0,05 yaitu 0,000. Formula gel ekstrak daun pepaya dengan konsentrasi 10% memiliki efek penyembuhan luka yang setara dengan kontrol positif (Bioplacenton®) dan lebih efektif dibandingkan dengan gel ekstrak konsentrasi 5%, gel ekstrak konsentrasi 15% dan basis gel. Kata Kunci: Gel, Ekstrak Daun Pepaya, Penyembuh Luka.

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“…The active components in papaya extract include flavonoids(A. Syah, 2022). Based on the introduction, this research aims to analyze papaya leaf extract (Carica Papaya L.) on healing suture wounds.…”

Section: Introductionmentioning

confidence: 99%

Carica Papaya L. With Suture Wound Healing in Mice Experimental Animals

Istiqomah,

Azizah,

Purwanti

et al. 2023

IMHSJ

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Background: Stitches are a condition in which skin tissue damage results from incisions or surgery and trauma. Carica Papaya Linn contains flavonoids which are efficacious as anti-inflammatory or antiseptic in inhibiting bacterial growth. Carica Papaya Linn is effective in repairing cells damaged by free radicals. The purpose of this study was to see the effectiveness of papaya leaf extract (Carica Papaya Linn) against stitches. Method: This research was quantitative research with a True Experimental design with the one group post-test method using the REEDA scale assessment. The population in this study were mice (Mus Musculus) which were divided into 5 groups, control group, nebacetin group, 5% test group, 10% test group and 15% test group. Research was conducted in the Lab. Medical Laboratory Technology at Muhammadiyah University of Sidoarjo and for making extracts from the Faculty of Mathematics and Natural Sciences, Surabaya State University. Data was collected and then the results were analysed using the One Way ANOVA statistical test. Result: The results of the statistical test showed a value of P = 0.000 in the 7th day group, which means there was a difference in each group of mice and the mean results showed the lowest result was 0.2 in the 15% extract which stated the best wound healing. Conclusion : The conclusion of the study was that there was an effect of giving papaya leaf extract (Carica Papaya L.) on wound healing in experimental mice.

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EFEKTIVITAS TANAMAN PEPAYA (Carica papaya L.) TERHADAP PENYEMBUHAN LUKA : A NARRATIVE REVIEW

Cited by 4 publications

References 4 publications

Antibacterial Activity and Determination of Total Phenol and Flavonoid of Carica papaya L. Ethanol Extract

Antibacterial Activity and Determination of Total Phenol and Flavonoid of Carica papaya L. Ethanol Extract

POTENSI GEL EKSTRAK DAUN PEPAYA (Carica papaya L.) SEBAGAI PENYEMBUH LUKA SAYAT PADA KELINCI

Carica Papaya L. With Suture Wound Healing in Mice Experimental Animals

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