EFEKTIVITAS EKSTRAK KUNYIT (CURCUMA DOMESTICA) TERHADAP JUMLAH SEL MAKROFAG DAN DIAMETER PADA LESI ULKUS TRAUMATIKUS  (suatu penelitian in vivo pada Tikus putih Jantan (Rattus norvegiccus))

Arisonya, Susanti; Wibisono, Gunawan; Aditya, Grahita

doi:10.33854/jbd.v1i2.16

Cited by 3 publications

(3 citation statements)

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“…Kunyit sering digunakan oleh masyarakat secara tradisional untuk mengobati berbagai jenis penyakit akibat mikrob, parasit, dan juga sebagai obat luka (Hartati, 2013). Arisonya et al (2014) menyatakan bahwa kunyit secara alami digunakan untuk merawat kulit dan membantu penyembuhan luka.…”

Section: Pendahuluanunclassified

Evaluasi aktivitas penyembuhan luka menggunakan krim campuran ekstrak teripang laut dan kunyit

Alpayet,

Mustika,

Rahma

et al. 2023

curr biomed

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Background: Skin is a layer of tissue from body that covers and protects the body from the danger that comes from outside and the environment. Skin is very susceptible to trauma, which is a cut wound. Objective: The purpose of the study was to determine the effectiveness of the mixture from sea cucumber and turmeric extract in cream dosage on rat’s cut wounds. Methods: This study used 15 white rats which were given a cut and the treatments of mixed cream with the different concentrations. The treatments were given by to dab the mixed cream on the wound area each day. The wound healing was observed on days 1, 7, 14 and 21, then the researchers gave scores on those wounds. The researcher measured the wound healing through the acceleration parameters of wound closure and inflammation reduction. Results: The results of this study showed that the rats wound completely closed on all area treatments and also showed that the healing time is faster than those who did not receive treatment. Conclusion: This result indicates that sea cucumber and turmeric extract have the potential and effective for heals the wounds and then can be used as an alternative for wound medicine.

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Section: Pendahuluanunclassified

Evaluasi aktivitas penyembuhan luka menggunakan krim campuran ekstrak teripang laut dan kunyit

Alpayet,

Mustika,

Rahma

et al. 2023

curr biomed

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“…Pemilihan tumbuhan sebagai upaya pengobatan dikarenakan tumbuhan obat memiliki harga yang terjangkau, mudah diperoleh, efek samping cenderung lebih kecil asal digunakan secara tepat (Larasati et al, 2019). Penggunaan obat-obatan tradisional sebenarnya juga telah dianjurkan oleh dari WHO, yaitu back to nature sebagai upaya dalam memelihara kesehatan (Arisonya, S., Wibisono, G. & Aditya, 2014).…”

Section: Pendahuluanunclassified

Inventarisasi Tumbuhan Obat Sebagai Upaya Swamedikasi Oleh Masyarakat Suku Mamasa Di Sulawesi Barat

2022

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Tumbuhan obat adalah tumbuhan yang digunakn untuk mengobati suatu penyakit dikarenakan tumbuhan tersebut mengandung zat aktif yang berfungsi untuk mengobati penyakit tertentu. Tujuan penelitian ini adalah untuk menginventarisir jenis tumbuhan yang bermanfaat sebagai obat tradisional, organ tumbuhan yang digunakan dan cara penggunaan tanaman obat tersebut yang dipergunakan oleh masyarakat di Desa Tondok Bakaru Kecamatan Mamasa Kabupaten Mamasa Sulawesi Barat. Teknik pengambilan sampel yang digunakan pada penelitian ini yaitu Purpose sampling dan metode pengambilan sampel dilakukan secara observasional dan wawancara mendalam terhadap penyehat tradisional (tabib) dan tokoh masyarakat. Hasil penelitian menunjukkan bahwa. bahwa terdapat 14 spesies tanaman yang digunakan sebagai obat tradisional yaitu murbei, pandan wangi, pegagan, kunyit, sambung nyawa, mint, tembelekan, jawer kotok, kembang sepatu, jambu biji, sirih, afrika, cocor bebek dan bandotan. Bagian tumbuhan yang paling banyak digunakan adalah daun dan cara pengolahan yang paling banyak adalah dengan cara diminum. Tumbuhan yang digunakan sebagai obat paling banyak ditemukan di pekarangan rumah.Medicinal plants are plants that are used to treat a disease because these plants contain active substances that serve to treat certain diseases. The purpose of this study is to inventory plant types that are useful as traditional medicines, plants used and how to use the drug plants used by the community in the village of Tokok Bakaru, Mamasa District, Mamasa Regency, West Sulawesi. The sampling technique used in this study was purpose sampling and the sampling method was carried out observationally and in-depth interviews on traditional obit (physical) and community leaders. The results showed that. That there are 14 species of plants used as traditional medicines namely Mulberry, Pandan Wangi, Pegagan, Turmeric, Nyawa, Mint, Teaching, Jawer Kotok, Hibiscus, Guava, Sirih, Africa, Cocor Duck and Bandotan. The most widely used plant parts are leaves and the most processing methods are by drinking. Plants used as the most drugs are found in the yard.

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“…In vivo activity showed an increase in the production of macrophage cells from TNF-α that occurred due to the effect on the COX-2 (cyclooxygenase-2) enzyme by curcumin resulting in the synthesis of nitric oxide and biomarkers of the inflammatory response. (Arisonya et al, 2014;Behera et al, 2011). Then in an in silico study, curcumin compounds showed immunostimulatory activity with an increase between the SARS-CoV 2 virus receptor causing hydrogen bonds and hydrophobic interactions that gave rise to good affinity.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review: Potential of Curcumin Compounds as Immunostimulants in the Prevention of SARS-CoV 2 Virus

Ma’arif

Suryanto

Lestari

et al. 2021

planar

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Curcumin is a compound from the turmeric rhizome plant (Curcuma longa), which has immunostimulating activity. This activity has been tested pre-clinically in vitro, in vivo, and in silico. It can be used as raw material for drugs in the development of new drugs to prevent the SARS-CoV 2 virus. The purpose of this study was to examine the immunostimulatory activity of turmeric in vitro, in vivo, and in silico and to explore the mechanism of curcumin compounds as immunostimulants. The method used in this systematic review is Systematic-Meta Analysis by identifying articles from several journal databases (Google Scholar, ResearchGate, ScienceDirect, and Garuda Dikti). Furthermore, the article selection process used a PRISMA guideline flow chart. This process found 15 articles as the main reference, five articles containing in vitro research, five in vivo, and five in silico from the turmeric rhizome plant. In vitro, preclinical tests show that curcumin compounds have an immunostimulating effect characterized by the occurrence of proliferation and activation in several types of immune system cells. In vivo study was proven by increased phagocytic activity and increased leukocyte production in experimental animals. Whereas in silico was demonstrated by the binding of various SARS-CoV 2 receptors.

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EFEKTIVITAS EKSTRAK KUNYIT (CURCUMA DOMESTICA) TERHADAP JUMLAH SEL MAKROFAG DAN DIAMETER PADA LESI ULKUS TRAUMATIKUS (suatu penelitian in vivo pada Tikus putih Jantan (Rattus norvegiccus))

Cited by 3 publications

References 0 publications

Evaluasi aktivitas penyembuhan luka menggunakan krim campuran ekstrak teripang laut dan kunyit

Evaluasi aktivitas penyembuhan luka menggunakan krim campuran ekstrak teripang laut dan kunyit

Inventarisasi Tumbuhan Obat Sebagai Upaya Swamedikasi Oleh Masyarakat Suku Mamasa Di Sulawesi Barat

Systematic Review: Potential of Curcumin Compounds as Immunostimulants in the Prevention of SARS-CoV 2 Virus

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