Efeitos do flavonóide quercetina e dos corantes bixina e norbixina sobre parâmetros sanguíneos de coelhos

Abstract

Efeitos do flavonóide quercetina e dos corantes bixina e norbixina sobre parâmetros sanguíneos de coelhos Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits R E S U M OAvaliou-se a ação terapêutica da quercetina, bixina e norbixina, na dose diária de 0,01mol/kg, em coelhos hiperlipidêmicos induzidos por colesterol a 0,5% e ácido cólico a 0,1%, durante o período de vinte e oito dias, após o qual foram dosados colesterol, colesterol-HDL, triacilgliceróis, uréia, creatinina, ácido úrico, proteínas totais, cálcio, aspartato aminotransferase e alanina aminotransferase. Estes estudos são importante para se verificarem os efeitos de flavonóides e corantes sobre o metabolismo destas substâncias, permitindo a interpretação de desordens hepáticas ou renais. Os resultados mostraram que os teores de colesterol foram menores para os animais tratados com bixina (-4,03%) e quercetina (-35,07%), enquanto sua associação reduziu o nível de uréia em 5,73%. Nenhuma das substâncias testadas apresentou efeitos deletérios, todavia, não é possível demonstrar a inocuidade destes compostos.Termos de indexação: quercetina, bixina, norbixina, metabolismo, coelhos da raça Nova Zelândia, colesterol, lipoproteínas do colesterol-HDL, uréia, flavonas. A B S T R A C TThe objective of this study was to evaluate the therapeutic action of quercetin, bixin and norbixin, in the daily dose of 0,01mol/kg, in hyperlipidemic rabbits induced by cholesterol at 0.5% and colic acid at 0.1%, during

Evaluation of subchronic toxicity of the hydroethanolic extract of Tropaeolum majus in Wistar rats

“…Studies suggest low toxicity of some flavonoids present in T. majus leaves as quercetin (isoquercitrin aglycone) (NTP, 1992;Lima et al, 2003;Hard et al, 2007;Harwood et al, 2007), and the enzymatic produced isoquercitrin (EMIQ) (Hasamura et al, 2004;Tamura et al, 2010). However, the medicinal plants represent a complex mix of chemical components with biological activities that can cause adverse effects and interact with other medications when used concomitantly (Holstege et al, 2005;Venkataramanan et al, 2006;Jordan et al, 2010).…”

Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats

“…A significant number of chemical properties and pharmacological effects have been attributed to quercetin in animal models, such as reduction of serum cholesterol levels 2 and anti-inflammatory action in lung injury. Rat models of various liver disorders have shown a hepatoprotective role of quercetin, which has been associated with increased survival in cirrhosis 3 and protection against induced liver damage 4,5 .…”

Aterosclerose experimental em coelhos

“…In our laboratory, we have been inducing hypercholesterolemia in rabbits by adding 1% of cholesterol to commercial chow in several studies with the purpose of investigating substances that can be further made viable as medications for the control of lipid metabolism, and also of developing tests of potential therapies and diagnosis between different experimental procedures [5][6][7][8][9][10][11][12] .…”