“…Hopkins et al 13 showed that in the knee joint of men, after effusion, both cryotherapy and TENS significantly reduced arthrogenic muscle inhibition, suggesting that the use of thermal resources in association with or prior to electrical resources, mainly cryotherapy, appears to interfere selectively in the neural activity of the sensory fibers (A and C delta) in animals and humans. [12][13][14] Some authors also show that in 87% of cases of acute and chronic pain, thermal resources (including cryotherapy) are the types of non-pharmacological analgesic therapeutic approaches frequently used prior to or in association with electrical resources 3,5,14 . Although from the electrophysiological perspective this common practice does not seem adequate, due to factors such as: changes in skin impedance, variations of tissue water content, alterations of the enzymatic and energetic metabolism and actions in the impulse transmission speed in the nerve fibers, among others caused by thermotherapy.…”