This study examined the adaptive responses of indicators of strength, bone mineral density (BMD), the resting metabolic rate (RMR) and aerobic capacity ( O 2 max and anaerobic threshold) after 16 weeks intervention resistance training program (RT). Participated 22 postmenopausal women (12 months without menstruation), subdivided in two groups: trained group (GT n = 12) and control group (GC n = 10). The RT period had frequency of three sessions per week on alternate days, with 10 exercises for upper limbs and lower limbs, and performed three sets of 10 repetitions maximum (RM) in step 1 and three sets of 8 RM in step 2. The levels of strength were measured by the 1-RM test, body composition was obtained by the method of skinfolds, the assessment of BMD was performed by densitometry of Radiological Dual Energy in the regions of lumbar spine and the femoral neck, and the RMR and O 2 max were obtained by indirect calorimetry and the RMR calculated using equation of Weir (1949). The O 2 max was obtained during progressive test on a treadmill until exhaustion. For statistical analysis we used the Kruskal-Wallis test to assess the effects of intra and inter RT and the Spearman correlation to the correlations used. The results showed statistically significant differences increase for the load being strength in the 1-RM tests and supine leg press for the GT and no change was found to GC. No significant differences were obtained for the BMD of the spine on both the femur, O 2 peak and the TMR in both groups. RT was effective to increase muscle strength, but 16 weeks were not sufficient to cause changes in BMD, in TMR and aerobic capacity.