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Cited by 7 publications
(10 citation statements)
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References 32 publications
(10 reference statements)
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“…It should be stressed that although several dysfunctions in the adult male MSG rat, a phenotype of hypothalamic obesity, have been extensively revisited [ 1 13 ], only few studies have been focused on the metabolic improvement induced by metformin treatment in these animals. Indeed, data from previous studies performed in MSG rats treated with a high daily metformin dose (300–500 mg/Kg BW) [ 32 34 ] indicate that the treatment improves glucose metabolism [ 32 34 ], blood pressure [ 34 ], and cardiovascular function [ 31 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…It should be stressed that although several dysfunctions in the adult male MSG rat, a phenotype of hypothalamic obesity, have been extensively revisited [ 1 13 ], only few studies have been focused on the metabolic improvement induced by metformin treatment in these animals. Indeed, data from previous studies performed in MSG rats treated with a high daily metformin dose (300–500 mg/Kg BW) [ 32 34 ] indicate that the treatment improves glucose metabolism [ 32 34 ], blood pressure [ 34 ], and cardiovascular function [ 31 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…Caldas et al 11 described the relationship between insulin and hypogonadism in men with metabolic syndrome and concluded that hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities. Ferreira et al 12 described the effects of metformin on blood pressure and glucose metabolism in monosodium glutamate–induced obese, spontaneously hypertensive rats. They also emphasized the role of hepatic insulin resistance on metabolic syndrome and pointed out that beneficial cardiovascular effects and improved insulin sensitivity were observed.…”
Section: Methodsmentioning
confidence: 99%
“…13 Apesar do menor peso corporal, a administração de MSG determinou importante aumento da gordura visceral e da glicemia de jejum sem, no entanto, promover elevação adicional da pressão arterial de cauda. Estudos prévios de nosso laboratório 8,9 , utilizando MSG, demonstraram que em ratos Wistar normotensos houve ganho de peso corporal e diminuição do ganho de peso corporal em SHR.…”
Section: Medida Da Obesidade Visceralunclassified
“…6,7 Nos últimos anos, o Laboratório de Hipertensão Arterial da Disciplina de Nefrologia da Universidade Federal de São Paulo (UNIFESP) adquiriu grande experiência em um modelo animal de obesidade neuroendócrina, por meio da administração neonatal de glutamato monossódico associada à hipertensão arterial genética. 8,9 A administração subcutânea de glutamato monossódico (MSG), um aminoácido neuroexcitatório lesivo ao sistema nervoso central, 10 resulta na degeneração aguda do núcleo arqueado do hipotálamo que leva, além da obesidade, à disfunção sexual, parada no crescimento, ao déficit comportamental em roedores 11 e a alterações no controle cardiovascular. 12 Mais ainda, os animais obesos desse modelo experimental desenvolvem maior deposição de tecido adiposo na região central, possivelmente em virtude de hipercortisolismo.…”
Section: Introductionunclassified