Efeito do treinamento físico em alterações induzidas pelo envelhecimento no músculo papilar do rato

Maifrino, Laura Beatriz Mesiano; Araújo, Rubens Correa; Faccini, Cristiane Castro; Liberti, Édson Aparecido; Gama, Eliane Florêncio; Ribeiro, Antônio Augusto Coppi Maciel; Souza, Romeu Rodrigues de

doi:10.1590/s0066-782x2009000500009

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…23,24 Metalloproteinase type 2 and type 9 also participate in the remodeling process of cardiac tissue, and are present in several pathologies such as inflammatory and cardiovascular diseases, among other injuries. [24][25][26][27][28][29] The expression of metalloproteinase type 9 did not differ between groups and parameters. Regarding metalloproteinase type 2, an increase was shown in the control group with ovariectomy and physical training even in the presence of dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress

Brianezi¹,

Ornelas²,

Gehrke³

et al. 2019

Arquivos Brasileiros De Cardiologia

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Background: The emergence of coronary heart disease is increased with menopause, physical inactivity and with dyslipidemia. Physical training is known to promote the improvement of cardiovascular functions. Objective: To investigate the effects of aerobic physical training on the left ventricle in ovariectomized LDL knockout mice. Methods: Thirty animals were divided into 6 groups (n = 5): Sedentary non-ovariectomized control; Sedentary ovariectomized control; Trained ovariectomized control; Sedentary non-ovariectomized LDL-knockout, sedentary ovariectomized LDL-knockout and trained ovariectomized LDL-knockout. We analyzed the average parameters of apparent density of collagen fibers types I and III, and metalloproteinase type 2 and type 9, were considered significant p < 0.05. Results: The results showed that the proposed exercise protocol altered the volume of type I collagen fibers, altered collagen remodeling parameters (MMP-2), and also reduced the 8-hydroxy-2'-deoxyguanosine (8OHdG) oxidative stress parameter. Conclusion: Moderate intensity aerobic training acts on collagen fiber volume, on collagen remodeling with the reduction of oxidative stress in the left ventricles of ovariectomized LDL-knockout mice.

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Section: Discussionmentioning

confidence: 99%

Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress

Brianezi¹,

Ornelas²,

Gehrke³

et al. 2019

Arquivos Brasileiros De Cardiologia

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Exercise changes the size of cardiac neurons and protects them from age-related neurodegeneration

Gama

Santarém

Liberti

et al. 2010

Annals of Anatomy - Anatomischer Anzeiger

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Efeito do treinamento físico em alterações induzidas pelo envelhecimento no músculo papilar do rato

Abstract: SummaryBackground: The effects of aging on papillary muscle have been widely demonstrated, but no data on the effects of exercise on the age-related changes are available.

Cited by 2 publications

References 34 publications

Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress

Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress

Exercise changes the size of cardiac neurons and protects them from age-related neurodegeneration

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