Efecto de la erradicación de Helicobacter pylori en la anemia ferropénica de origen incierto

Roldán, Francisco Pérez; Monedero, Jesús Javier Castellanos; Carro, Pedro González; García, María del Mar Ballesteros; García-Escribano, O. Roncero; Huidobro, María Luisa Legaz; Carrillo, Francisco Ruiz

doi:10.1157/13117901

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Our data have agreed with previous reports on no significant association between chronic H.p infection and anemia [13–16]. Some studies have reported decreased iron store in positive H.p infection populations [17–20]. We also noted all the features of iron storage, such as lower levels of serum iron and ferritin and higher levels of total iron-binding capacity (TIBC).…”

Section: Discussionsupporting

confidence: 93%

Helicobacter pyloriInfection and Anemia in Taiwanese Adults

Shih

Kuo

Wang

et al. 2013

Gastroenterology Research and Practice

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Background. Chronic Helicobacter pylori infection and iron-deficiency anemia (IDA) are common in adults. Although the most common causes of IDA usually arise from the gastrointestinal tract, the association between chronic Helicobacter pylori infection and anemia remains unclear. Aim. To evaluate the association of chronic Helicobacter pylori infection and IDA. Materials and Methods. We enrolled 882 patients from January 2010 to April 2013. The status of Helicobacter pylori (H.p) infection was confirmed and blood samples from the same participants were taken on the same day to check the level of hemoglobin, serum iron, ferritin, and total iron-binding capacity (TIBC). Results. No significant difference was noted from the demographic data. The average level of hemoglobin (Hb) was not different between negative and positive groups, pos 13.57 g/dL versus neg 13.65 g/dL (P = 0.699). Although the levels of serum IDA related parameters were expected in positive group (lower serum iron and ferritin and higher TIBC) these differences did not reach statistical significance (P = 0.824 for iron, P = 0.360 for ferritin, and P = 0.252 for TIBC). Conclusion. Chronic Helicobacter pylori infection is not attributed to IDA. The levels of hemoglobin, serum iron and ferritin, and TIBC remain unaffected after chronic H.p infection. Large-scale clinical studies are needed to prove the association.

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Section: Discussionsupporting

confidence: 93%

Helicobacter pyloriInfection and Anemia in Taiwanese Adults

Shih

Kuo

Wang

et al. 2013

Gastroenterology Research and Practice

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“…Special attention should be paid to the reported cases of iron deficiency anaemia concomitant to H. pylori infection, in which anaemia was the only symptom of the infection [29, 30]. The association between H. pylori infection and impaired absorption of iron is also corroborated by the documented improvement of haematological parameters after complete elimination of the bacterium [25, 28, 31–33]. …”

Section: Absorption Of Non-haem Ironmentioning

confidence: 99%

The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract

Przybyszewska¹,

Żekanowska

2014

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Iron is found in almost all foods, so dietary iron intake is related to energy intake. However, its availability for absorption is quite variable, and poor bioavailability is a major reason for the high prevalence of nutritional iron deficiency anaemia. Absorption occurs primarily in the proximal small intestine through mature enterocytes located at the tips of the duodenal villi. Two transporters: Hem Carrier Protein 1 (HCP1) and Divalent Metal Transporter 1 (DMT1) appear to mediate the entry of most if not all dietary iron into these mucosal cells. Absorption is regulated according to the body's needs. The results of studies suggest that iron absorption is regulated by the control of iron export from duodenal enterocytes to the circulating transferrin pool by ferroportin. Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded. Therefore, hepcidin is now considered to be the most important factor controlling iron absorption.

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Extragastric Manifestations of Helicobacter pylori Infection: Other Helicobacters

et al. 2008

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The finding that Helicobacter pylori is the main cause of gastritis and peptic ulcer disease has opened a new era in the gastrointestinal world. Today there is evidence that H. pylori may also play a role in different nongastric diseases, opening the new "extragastric manifestations of H. pylori infection" field. Concerning this, several studies have been published in the last year. The most convincing data arise from those investigating idiopathic thrombocytopenic purpura and sideropenic anemia, while there is also an increasing evidence for a possible association with atherosclerotic disease. Furthermore, the discovery of a number of other novel Helicobacter species has stimulated the research in different extragastric diseases, in which an infectious hypothesis is plausible. In particular, several species have been studied for a potential role in different liver and intestinal diseases with interesting findings.

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Efecto de la erradicación de Helicobacter pylori en la anemia ferropénica de origen incierto

Cited by 3 publications

References 9 publications

Helicobacter pyloriInfection and Anemia in Taiwanese Adults

Helicobacter pyloriInfection and Anemia in Taiwanese Adults

The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract

Extragastric Manifestations of Helicobacter pylori Infection: Other Helicobacters

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