Efecto de la administración semanal de ácido fólico sobre los valores sanguíneos

Villarreal, Laura Elia Martínez-de; Limón-Benavides, Carmen; Valdéz-Leal, Ramón; Sánchez-Peña, María Alejandra; Villarreal-Pérez, Jesús Zacarías

doi:10.1590/s0036-36342001000200004

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…The increases and patterns attained in serum and red blood cell folate by both folic acid dosage regimens in the present trial are in line with previous studies (22)(23)(24) , but direct comparisons on absolute values cannot be made because of differences in laboratory procedures. However, in 2001 Martinez et al (23) carried out a supplementation trial with a weekly dosage of 5 mg folic acid among non-pregnant women of childbearing age in Nuevo Leo ´n, Mexico, using similar laboratory tests. These authors found after 12 weeks that serum and red blood cell folate levels increased from 5?93 to 7?0 ng/ml (18 %) and from 150?5 to 184?0 ng/ml (22 %), respectively.…”

Section: Discussionsupporting

confidence: 90%

“…However, in 2001 Martinez et al . ( 23 ) carried out a supplementation trial with a weekly dosage of 5 mg folic acid among non-pregnant women of childbearing age in Nuevo León, Mexico, using similar laboratory tests. These authors found after 12 weeks that serum and red blood cell folate levels increased from 5·93 to 7·0 ng/ml (18 %) and from 150·5 to 184·0 ng/ml (22 %), respectively.…”

Section: Discussionmentioning

confidence: 99%

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Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Rosenthal

Milla²,

Flores

et al. 2008

Public Health Nutr.

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Background: Observational studies and clinical trials have shown conclusive evidence that periconceptional folic acid supplementation prevents up to 70 % of neural tube defects (NTD). The Honduran government wanted to implement a supplementation programme of folic acid but needed to assess the relative effects of two dosages of folic acid. Objective: To determine the effect of two dosages of folic acid on blood folate levels in Honduran female factory workers aged 18 to 49 years. Design: This was a randomized, double-blind control supplementation trial conducted in Choloma, Honduras. A total of 140 eligible women were randomly assigned to two dosage groups and followed up for 12 weeks. One group received a daily dosage of 1 mg folic acid and the other a once weekly dosage of 5 mg. Serum folate and red blood cell folate levels were determined by radioassay at baseline, 6 weeks and 12 weeks. Results: Serum folate levels increased from 6?3 (SE 0?2) to 14?9 (SE 0?6) ng/ml (P , 0?0001) in women assigned to the 1 mg/d group and from 6?9 (SE 0?3) to 10?1 (SE 0?4) ng/ml (P , 0?0001) in those assigned to the 5 mg/week group. Red blood cell folate concentrations also increased significantly in both groups, albeit more slowly. Educational level, age and BMI were not associated with the changes in serum and red blood cell folate levels during the supplementation period. However, a differential effect on serum folate levels by dosage group and time was observed. Conclusions: Although both folate supplementation regimens increased serum and red blood cell folate levels significantly among the women studied, blood folate levels that are considered to be protective of NTD were reached faster with the daily dosage of 1 mg folic acid.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Rosenthal

Milla²,

Flores

et al. 2008

Public Health Nutr.

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“…Results showed that after 3 months there was a compliance rate of 91.4% and a significant increase in plasma and red blood cell folate (RBC). It is important to mention that the basal blood levels were low and post implementation, increased to 200 ng/dl (432 nMol/L) [8]. With these results, a NTD prevention program was initiated by the State Secretary of Health, together with the School of Medicine of the University of Nuevo Leon.…”

Section: Introductionmentioning

confidence: 99%

Should the dose of folic acid be adjusted for Mexican population? The pilot prevention program implemented in Nuevo Leon, Mexico

Villarreal¹

2017

PRM

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Abstract. In 1980 Smithells et al. reported that the intake of folic acid (FA) prevents the recurrence of neural tube defects (NTDs) [1]. After this and several other studies were conducted, the intake of 400 micrograms of folic acid per day, at least three months before and three months during pregnancy for prevention of NTD, was proposed [2,3,4]. Other strategies were also developed to increase folate blood levels in woman of childbearing age such as promoting the consumption of folate rich foods and food fortification (flour and most recently rice) [5]. Nevertheless, results have not been as expected due to poor consumption of folic acid supplements [6]. As a result, in the year 2000, a novel strategy was developed in order to increase folate blood levels in Mexican women. The results of the strategy are presented, as well as, a discussion about how to personalize a program for different populations.

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“…En un estudio previo, demostramos que la administración semanal de 5.0 mg de ácido fólico por vía oral incrementaban significativamente los valores sanguíneos de ácido fólico en mujeres en edad fértil (7).…”

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Efecto Del Consumo De Harina De Maíz Fortificada Con Acido Fólico Sobre Los Niveles De Folatos Sanguíneos en Mujeres De Edad Fértil

P¹,

S²,

V³

et al. 2011

Rev. chil. nutr.

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INTRODUCCIÓNEn la literatura médica existe evidencia indiscutible que el consumo de ácido fólico en el período periconcepcional previene en 50 y 75% defectos del tubo neural (DTN) por lo que se recomienda aumentar el consumo de alimentos ricos en folatos y/o fortificados (1). El Centro para el Control de las Enfermedades (CDC) de los Estados Unidos con la finalidad de aumentar los valores de folatos en la población, emitió la recomendación que todas las mujeres en edad fértil, sin antecedentes familiares de DTN deben consumir 400 µg (0.4 mg) de ABSTRACT Fortification of foods is now widely used to prevent folate deficiency. Folic acid has been added to corn flour and its efficacy in the prevention of NTD has been proved. The aim of this study was to compare the effect of the intake of fortified corn-flour versus non fortified flour and to folic acid supplement, on blood folate levels in women of childbearing age. Forty-five women were randomized into three groups according to: (A) use of fortified flour (n=18), (B) non-fortified flour (n=17); (C) supplementation with 5 mg of oral folic acid (n=10). All females answer a dietary and anthropometric questionnaire applied once a month during three months. Blood red cell (IE) and plasmatic (P) folate were measured at the beginning and at the end of the study; also the DNA analysis for the 677T mutation was performed. The corn flour was provided to groups A and B during three months, to be consumed as eight tortillas daily. Group C received 5.0 mg tablet of folic acid (Valdecasas®), once per week, during three months. IE and P folate and hematocrito were significantly increased in women from group C (p<0.05). Only plasmatic folic acid levels were significantly increased in women from groups A and B. Genotype distribution was: 15.6% homozygous TT, 42.2% C/C and 42.2% CT. Weekly administration of 5.0 mg of folic acid is an effective way to increase blood folate levels and shows to be more efficient than fortified corn flour.

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Efecto de la administración semanal de ácido fólico sobre los valores sanguíneos

Cited by 12 publications

References 10 publications

Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Should the dose of folic acid be adjusted for Mexican population? The pilot prevention program implemented in Nuevo Leon, Mexico

Efecto Del Consumo De Harina De Maíz Fortificada Con Acido Fólico Sobre Los Niveles De Folatos Sanguíneos en Mujeres De Edad Fértil

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