Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Rosenthal, Jorge; Milla, Gayle; Flores, Alina L.; Yon, Michele; Pfeiffer, Christine M.; Umaña, Edgardo; Skerrette, Nyasha I.; Barahona, F

doi:10.1017/s1368980008002255

Cited by 5 publications

(21 citation statements)

References 44 publications

(52 reference statements)

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“…The included trials mainly focused on maternal outcomes and a subset divulged outcomes related to neonatal health. There were two randomized controlled trials (RCTs) [56,57] and three quasi-experimental natural experiments [55,58,59]. The primary outcome reported was a neural tube defect.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Of the five included trials, two took place in Asia: two in China [55,56]. One trial took place in North America, in Honduras [57], and two trials took place in South America: one in Cuba [58] and one in Brazil [59]. All participants were non-pregnant women with ages ranging from 16 to 49 years, and the sample sizes ranged from 140 [57] to 247,831 [55].…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Five trials [55][56][57][58][59] used periconceptional folic acid supplementation alone. Three trials supplemented women with 0.4 mg folic acid per day [55,56,59], while in the remaining trials, women were supplemented with 1 mg [57], 4 mg, and 5 mg [58] of folic acid daily. Participants were supplemented daily in all of the trials; however, one trial also had a 5 mg weekly arm [57].…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Two trials were RCTs [56,57] and the remaining three were quasi-randomized studies [55,58,59] (Figure 3).…”

Section: Risk Of Biasmentioning

confidence: 99%

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Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review

et al. 2020

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Pregnancy in adolescence and malnutrition are common challenges in low- and middle-income countries (LMICs), and are associated with many complications and comorbidities. The preconception period is an ideal period for intervention as a preventative tactic for teenage pregnancy, and to increase micronutrient supplementation prior to conception. Over twenty databases and websites were searched and 45 randomized controlled trials (RCTs) or quasi-experimental interventions with intent to delay the age at first pregnancy (n = 26), to optimize inter-pregnancy intervals (n = 4), and supplementation of folic acid (n = 5) or a combination of iron and folic acid (n = 10) during the periconception period were included. The review found that educational interventions to delay the age at first pregnancy and optimizing inter-pregnancy intervals significantly improved the uptake of contraception use (RR = 1.71, 95% CI = 1.42–2.05; two studies, n = 911; I2 = 0%) and (RR = 2.25, 95% CI = 1.29–3.93; one study, n = 338), respectively. For periconceptional folic acid supplementation, the incidence of neural tube defects were reduced (RR = 0.53; 95% CI = 0.41–0.77; two studies, n = 248,056; I2 = 0%), and iron-folic acid supplementation improved the rates of anemia (RR = 0.66, 95% CI = 0.53–0.81; six studies; n = 3430, I2 = 88%), particularly when supplemented weekly and in a school setting. Notwithstanding the findings, more robust RCTs are required from LMICs to further support the evidence.

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Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

“…Two trials were RCTs [56,57] and the remaining three were quasi-randomized studies [55,58,59] (Figure 3).…”

Section: Risk Of Biasmentioning

confidence: 99%

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Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review

et al. 2020

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“…| 13 of 119 Honduras (Rosenthal, 2008), and one in South America: Brazil (Wehby et al, 2012). One study in Carribean: Cuba (Vergel et al, 1990).…”

Section: Periconceptional Folic Acidmentioning

confidence: 99%

Effects of preconception care and periconception interventions on maternal nutritional status and birth outcomes in low‐ and middle‐income countries: A systematic review

Lassi

Kedzior

Tariq

et al. 2021

Campbell Systematic Reviews

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Background: The preconception period is an ideal time to introduce interventions relating to nutrition and other lifestyle factors to ensure good pregnancy preparedness, and to promote health of mothers and babies. In adolescents, malnutrition and early pregnancy are the common challenges, particularly among those who live in lowand middle-income countries (LMIC) where 99% of all maternal and newborn deaths occur. These girls receive little or no attention until their first pregnancy and often the interventions after pregnancy are too late to revert any detrimental health risks that may have occurred due to malnutrition and early pregnancy.Objectives: To synthesise the evidence of the effectiveness of preconception care interventions relating to delayed age at first pregnancy, optimising inter-pregnancy intervals, periconception folic acid, and periconception iron-folic acid supplementation on maternal, pregnancy, birth and child outcomes.Search Methods: Numerous electronic databases (e.g., CINAHL, ERIC) and databases of selected development agencies or research firms were systematically searched for all available years up to July 2019. In addition, we searched the reference lists of relevant articles and reviews, and asked experts in the area about ongoing and unpublished studies.Selection Criteria: Primary studies, including large-scale programme evaluations that assessed the effectiveness of interventions using randomised controlled trials (RCTs) or quasi-experimental designs (natural experiments, controlled before-after studies, regression discontinuity designs, interrupted time series [ITS]), that targeted women of reproductive age (i.e., 10-49 years) during the pre-and periconceptional period in LMICs were included. Interventions were compared against no intervention, standard of care or placebo.

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Effects and safety of periconceptional oral folate supplementation for preventing birth defects

De-Regil

Peña-Rosas

Fernández-Gaxiola

et al. 2015

Cochrane Database of Systematic Reviews

459

297

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Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Cited by 5 publications

References 44 publications

Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review

Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review

Effects of preconception care and periconception interventions on maternal nutritional status and birth outcomes in low‐ and middle‐income countries: A systematic review

Effects and safety of periconceptional oral folate supplementation for preventing birth defects

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