EEG responses to standardised noxious stimulation during clinical anaesthesia: a pilot study

Anders, Malte; Anders, Björn; Dreismickenbecker, Elias; Hight, Darren; Kreuzer, Matthias; Walter, Carmen; Zinn, Sebastian

doi:10.1016/j.bjao.2022.100118

Cited by 6 publications

(9 citation statements)

References 62 publications

(94 reference statements)

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“…The situation is much clearer in the adult bird. Physiological responses including spectral changes in the EEG to nociceptive stimuli have been described for awake birds [62][63][64] , being consistent with those observed in awake mammals 13,39,40,43,64 . The neuroanatomical prerequisites such as cutaneous mechanical, thermal, chemical and polymodal nociceptors are present and respond to external stimulation similar to mammalian nociceptors 3,65,66 .…”

Section: Electrical and Thermal Stimulationsupporting

confidence: 78%

“…EEG signals from EEG1 were analyzed with a wavelet transform portion of the newtimeffunction with 3 cycles at the lowest frequency of 3Hz and 20 cycles at the highest frequency of 100Hz. In the ERSP results, any deactivation or activation below a threshold of -2dB or above a threshold of +2dB was considered as a response to the stimulus 39,40,43 . For the analysis of all baseline EEG recordings and stimuli-locked EEGs, 6 randomly selected datasets from each development stage (ED07-ED19)…”

Section: Eeg Data Processingmentioning

confidence: 99%

“…The phase-locked response in the EEG after electrical stimulation was expected rather immediately after the onset of the stimulus (below 100ms). The EEG response after thermal stimulation was expected well after the onset of the stimuli due to ∆Theating of the Peltier-element (between 100ms and 800ms) 39,40,43 .…”

Section: Physiological Anticipationsmentioning

confidence: 99%

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Nociception in chicken embryos, Part II: Embryonal development of electroencephalic neuronal activityin ovoas a prerequisite for nociception

Kollmansperger

Anders

Werner

et al. 2023

Preprint

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Chicken culling is forbidden in Germany since 2022, male/female selection and male elimination must be brought to an embryonic status prior to the onset of nociception. The present study evaluated the ontogenetic point when noxious stimuli potentially could be perceived/processed in the brainin ovo.EEG-recordings from randomized hyperpallial brain sites were recordedin ovoand noxious stimuli were applied. Temporal and spectral analyses of the EEG were performed.The onset of physiological neuronal signals could be determined at developmental day 13. ERP/ERSP/ITC analysis did not reveal phase-locked nociceptive responses.Although no central nociceptive responses were documented, adequate EEG-responses to noxious stimuli from other brain areas cannot be excluded. The extreme stress impact on the embryo during the recording may overwrite the perception of noniceptive stimuli. The results suggest developmental day 13 as the earliest embryonal stage being able to receive and process nociceptive stimuli.

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Section: Electrical and Thermal Stimulationsupporting

confidence: 78%

Section: Eeg Data Processingmentioning

confidence: 99%

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Nociception in chicken embryos, Part II: Embryonal development of electroencephalic neuronal activityin ovoas a prerequisite for nociception

Kollmansperger

Anders

Werner

et al. 2023

Preprint

Self Cite

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show abstract

“…The situation is much clearer in the adult bird. Physiological responses including spectral changes in the EEG to nociceptive stimuli have been described for awake birds [4,5,60], which are consistent with those observed in awake mammals [13,39,40,43,60]. The neuroanatomical prerequisites such as cutaneous mechanical, thermal, chemical and polymodal nociceptors are present and respond to external stimulation similar to mammalian nociceptors [3,60,61].…”

Section: Electrical and Thermal Stimulationsupporting

confidence: 74%

Nociception in Chicken Embryos, Part II: Embryonal Development of Electroencephalic Neuronal Activity In Ovo as a Prerequisite for Nociception

Kollmansperger,

Anders,

Werner

et al. 2023

Animals

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Chicken culling has been forbidden in Germany since 2022; male/female selection and male elimination must be brought to an embryonic status prior to the onset of nociception. The present study evaluated the ontogenetic point at which noxious stimuli could potentially be perceived/processed in the brain in ovo. EEG recordings from randomized hyperpallial brain sites were recorded in ovo and noxious stimuli were applied. Temporal and spectral analyses of the EEG were performed. The onset of physiological neuronal signals could be determined at developmental day 13. ERP/ERSP/ITC analysis did not reveal phase-locked nociceptive responses. Although no central nociceptive responses were documented, adequate EEG responses to noxious stimuli from other brain areas cannot be excluded. The extreme stress impact on the embryo during the recording may overwrite the perception of noniceptive stimuli. The results suggest developmental day 13 as the earliest embryonal stage being able to receive and process nociceptive stimuli.

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“…The presented manuscript is a subanalysis of our previously published results, from which the described methodology and research question was derived (17). This publication is also part of a series of publications on the establishment of the applied methodology (15,(17)(18)(19). The research questions were designed to identify whether there are differences in pain perception and the noxious processing of standardized, painful stimuli using EEG and HPT in sports with the same modality, i.e., endurance.…”

Section: Methodsmentioning

confidence: 99%

Nociceptive Processing of Elite Athletes Varies between Sport-Specific Loads: An EEG-Based Study Approach

DREISMICKENBECKER,

FLECKENSTEIN,

WALTER

et al. 2024

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction For the downstream nociceptive processing of elite athletes recent studies indicate that athletes probably tolerate more pain as compared to a normally active population. Phenotyping the nociceptive processing of athletes in different types of endurance sports can provide insight into training-specific effects, which may help in understanding the long-term effects of specific exercise. Methods 26 elite endurance athletes from the disciplines of rowing, triathlon and running, and 26 age and sex-matched, recreationally active control subjects the subjective pain perception and processing of standardized noxious stimuli were investigated by EEG. This included standardized heat pain thresholds (HPT) and contact heat-evoked potentials (CHEPS) from heat stimulation, measured with EEG as well as pinprick-evoked potentials (PEP) from mechanical stimulation. Results Following noxious stimulation, athletes showed a higher activation of the event-related spectral perturbation (ERSP) patterns in the N2P2 EEG response at the Cz Electrode compared to the controls. Following noxious contact heat stimulation, triathletes had a higher ERSP activation compared to the controls, while the rowers had a higher ERSP activation following noxious mechanical stimulation. Also, HPTs in triathletes were increased despite their increased central activation following thermal stimulation. We found a correlation between increased HPTs and training hours and years, though athletes did not differ within these variables. Conclusions Although we were able to identify differences between athletes of different endurance sports, the reasons and implications of these differences remain unclear. The study of sport-specific somatosensory profiles may help to understand the mechanisms of exercise-related long-term effects on pain processing and perception. Furthermore, sport-specific somatosensory effects may support the personalization of exercise interventions and identify risk factors for chronic pain in elite athletes.

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EEG responses to standardised noxious stimulation during clinical anaesthesia: a pilot study

Cited by 6 publications

References 62 publications

Nociception in chicken embryos, Part II: Embryonal development of electroencephalic neuronal activityin ovoas a prerequisite for nociception

Nociception in chicken embryos, Part II: Embryonal development of electroencephalic neuronal activityin ovoas a prerequisite for nociception

Nociception in Chicken Embryos, Part II: Embryonal Development of Electroencephalic Neuronal Activity In Ovo as a Prerequisite for Nociception

Nociceptive Processing of Elite Athletes Varies between Sport-Specific Loads: An EEG-Based Study Approach

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