EEG power spectrum analysis for monitoring depth of anaesthesia during experimental surgery

Otto, K

doi:10.1258/la.2007.006025

Cited by 44 publications

(47 citation statements)

References 113 publications

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“…Noxious stimuli elicit changes in the activity of the cerebral cortex under light general anaesthesia, with these changes being attenuated or abolished with deepening anaesthesia (Otto 2008). In mammals, the minimal anaesthesia model (Murrell & Johnson 2006) has been used extensively to study the EEG effects of noxious stimuli and to compare the efficacy of different analgesic regimens (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…In mammals, increasing depth of anaesthesia is generally associated with EEG synchronization, characterized by a shift towards high amplitude, low frequency activity (Clark & Rosner 1973; Otto 2008). Such EEG changes may be quantified, for example, by calculating variables such as the median frequency (F50), spectral edge frequency (F95) and total power (Murrell et al .…”

Section: Introductionmentioning

confidence: 99%

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Effects of halothane on the electroencephalogram of the chicken

McIlhone

Beausoleil

Kells

et al. 2018

Veterinary Medicine & Sci

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Little is known about the effects of inhalant anaesthetics on the avian electroencephalogram (EEG). The effects of halothane on the avian EEG are of interest, as this agent has been widely used to study nociception and analgesia in mammals. The objective of this study was to characterize the effects of halothane anaesthesia on the EEG of the chicken. Twelve female Hyline Brown chickens aged 8–10 weeks were anaesthetized with halothane in oxygen. For each bird, anaesthesia was progressively increased from 1–1.5 to 2 times the Minimum Anesthetic Concentration (MAC), then progressively decreased again. At each concentration, a sample of EEG was recorded after a 10‐min stabilization period. The mean Total Power (PTOT), Median Frequency (F50) and 95% Spectral Edge Frequency (F95) were calculated at each halothane MAC, along with the Burst Suppression Ratio (BSR). Burst suppression was rare and BSR did not differ between halothane concentrations. Increasing halothane concentration from 1 to 2 MAC resulted in a decrease in F50 and increase in PTOT, while F95 increased when MAC was reduced from 1.5 to 1. The results indicate dose‐dependent spectral EEG changes consistent with deepening anaesthesia in response to increasing halothane MAC. As burst suppression was rare, even at 1.5 or 2 times MAC, halothane may be a suitable anaesthetic agent for use in future studies exploring EEG activity in anaesthetized birds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of halothane on the electroencephalogram of the chicken

McIlhone

Beausoleil

Kells

et al. 2018

Veterinary Medicine & Sci

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“…12 Electroencephalogram (EEG) power spectrum is a method of EEG signal analysis which provides more accurate information for determining brain functions than traditional EEG techniques. 13,14 Electroencephalogram power spectrum has been used to assess the level of consciousness and the depth of anesthesia. 15 Gradual increase of ICP will lead to change of ABSTRACT: Objectives: To investigate the feasibility of Electroencephalogram (EEG) power spectrum analysis as a noninvasive method for monitoring intracranial pressure (ICP).…”

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confidence: 99%

A New Method of Intracranial Pressure Monitoring by EEG Power Spectrum Analysis

Chen

Wang

Sizhong

et al. 2012

Can. J. Neurol. Sci.

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At present, intracranial pressure (ICP) can be reliably measured directly by invasive techniques such as ventriculostomy tube 1,2 , which require special equipment for the placement of monitoring probes. The most common side effect is intracranial infection. 3-5 lumbar puncture (lP) is one of the most common methods of ICP measurement, however, when ICP is very high, it should be performed with caution to avoid inducing brain herniation which may lead to death. 6 In recent years, some noninvasive ICP monitoring methods have been reported, including transcranial doppler, 7-9 jugular venous oxygen concentration monitoring, measurement of tympanic membrane displacement, 10,11 and retinal venous pressure measurement, however, none of these methods is sufficiently accurate to be allowed for routine clinical use.As we know, it is now possible to record and monitor the continuous digital EEG, and continuous EEG monitoring provides dynamic information about brain function. 12 Electroencephalogram (EEG) power spectrum is a method of EEG signal analysis which provides more accurate information for determining brain functions than traditional EEG techniques. 13,14 Electroencephalogram power spectrum has been used to assess the level of consciousness and the depth of anesthesia. 15 Gradual increase of ICP will lead to change of ABSTRACT: Objectives: To investigate the feasibility of Electroencephalogram (EEG) power spectrum analysis as a noninvasive method for monitoring intracranial pressure (ICP). Methods: The EEG signals were recorded in 62 patients (70 cases) with central nervous system (CNS) disorders in our hospital. By using self-designed software, EEG power spectrum analysis was conducted and pressure index (PI) was calculated automatically. Intracranial pressure was measured by lumbar puncture (lP). Results: We found a significant negative correlation between PI and ICP (r = -0.849, p < 0.01). Conclusions: The PI obtained from EEG analysis is correlated with ICP. Analysis of specific parameters from EEG power spectrum might reflect the ICP.RÉSUMÉ: Une nouvelle méthode de surveillance de la pression intracrânienne par analyse des spectres de puissance de l'EEG. Objectifs : le but de l'étude était d'évaluer la faisabilité de l'analyse des spectres de puissance de l'EEG comme méthode non effractive de surveillance de la pression intracrânienne (PIC). Méthode : les signaux EEG ont été enregistrés chez 62 patients (70 observations) atteints de troubles du système nerveux central (SNC) dans notre hôpital. Nous avons effectué une analyse des spectres de puissance de l'EEG et l'indice de pression (IP) a été calculé automatiquement. la pression intracrânienne a été mesurée par ponction lombaire. Résultats : Nous avons observé une corrélation négative significative entre l'IP et la PIC (r = -0,849 ; p < 0,01).

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“…54 The causes of these differences between adult and young animals and humans apparently remain unclear. 55 An additional complication is that in newborn and young lambs, which are neurologically mature at birth, the EEG responded to noxious stimulation with desynchronization. 31,56 Further studies will be necessary to elucidate the causes of these differences.…”

Section: Discussionmentioning

confidence: 99%

Electroencephalographic responses to tail clamping in anaesthetized rat pups

et al. 2009

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We investigated electroencephalographic (EEG) responses to tail clamping in lightly anaesthetized rat pups (5-22 days) in order to determine the ontogeny of EEG activity and at what age they may be capable of experiencing pain. Median frequency (F50) and spectral edge frequency (F95) of the power spectrum in the range of 1-30 Hz were determined before and after the application of a noxious stimulus and power spectra were compared by multivariate analysis. There was a postnatal increase in EEG power as, before clamping, pups aged 5-7 days exhibited isoelectric traces, whereas those aged 12-14 days and 21-22 days had intermittent EEG activity where the power in all frequencies was significantly lower at the former than at the latter age. Pups aged 5-7 days exhibited no EEG response to clamping in view of their isoelectric traces. Pups aged 12-14 days showed a significant decrease in F95 (P ¼ 0.002), whereas those aged 21-22 days showed highly significant reduction in F50 and F95 (P ¼ 0.028 and P , 0.001, respectively) as well as changes in EEG power of specific frequencies after clamping. The results and related literature suggest that rat pups aged 5-7 days and younger are not likely to perceive pain and that the ability to perceive pain develops gradually between postnatal ages 12-14 days and 21-22 days.

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EEG power spectrum analysis for monitoring depth of anaesthesia during experimental surgery

Cited by 44 publications

References 113 publications

Effects of halothane on the electroencephalogram of the chicken

Effects of halothane on the electroencephalogram of the chicken

A New Method of Intracranial Pressure Monitoring by EEG Power Spectrum Analysis

Electroencephalographic responses to tail clamping in anaesthetized rat pups

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