EEG dipole source localization of interictal spikes in non-lesional TLE with and without hippocampal sclerosis

Oliva, Megan; Meckes-Ferber, Stefanie; Roten, Annie; Desmond, Patricia; Hicks, Rodney J.; O’Brien, Terence J.

doi:10.1016/j.eplepsyres.2010.09.006

Cited by 15 publications

(6 citation statements)

References 29 publications

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“…Using quantitative EEG one investigation demonstrated that 62% of MTLE patients had dipole source localization in the epileptogenic temporal lobe (6). Two main types of dipole orientation were described, one with vertical orientation corresponding to inferior or basal temporal spikes and the second with horizontal orientation corresponding to lateral temporal spikes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Interictal Epileptiform Discharges in Mesial Temporal Lobe Epilepsy Using Quantitative EEG and Neuroimaging

et al. 2020

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Objective: Investigate areas of correlation between gray matter volumes by MRI and interictal EEG source maps in subtypes of mesial temporal lobe epilepsy (MTLE).Method: 71 patients and 36 controls underwent 3T MRI and and routine EEG was performed. Voxel-based morphometry (VBM) was used for gray matter analysis and analysis of interictal discharge sources for quantitative EEG. Voxel-wise correlation analysis was conducted between the gray matter and EEG source maps in MTLE subtypes.Results: The claustrum was the main structure involved in the individual source analysis. Twelve patients had bilateral HA, VBM showed bilateral hippocampal. Twenty-one patients had right HA, VBM showed right hippocampal and thalamic atrophy and negatively correlated involving the right inferior frontal gyrus and insula. Twenty-two patients had left HA, VBM showed left hippocampal atrophy and negatively correlated involving the left temporal lobe and insula. Sixteen patients had MTLE without HA, VBM showed middle cingulate gyrus atrophy and were negatively correlated involving extra-temporal regions, the main one located in postcentral gyrus.Conclusions: Negative correlations between gray matter volumes and EEG source imaging. Neuroanatomical generators of interictal discharges are heterogeneous and vary according to MTLE subtype.Significance: These findings suggest different pathophysiological mechanisms among patients with different subtypes of MTLE.

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Section: Introductionmentioning

confidence: 99%

Analysis of Interictal Epileptiform Discharges in Mesial Temporal Lobe Epilepsy Using Quantitative EEG and Neuroimaging

et al. 2020

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“…Third, inclusion criteria were restricted to ESI studies using 64 EEG electrodes, as this is considered to be the minimum number of channels necessary for accurate localization [51,48,80]. Yet, several studies on surgical candidacy have applied ESI based on more widely clinical available long term EEG systems and report sensitivity and specificity ranging between 50-62% and 17-50% [21,65]. The number of electrodes should not be considered the sole criterion.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of interictal source imaging in presurgical epilepsy evaluation: A systematic review from the E-PILEPSY consortium

Mouthaan

Rados

Boon

et al. 2019

Clinical Neurophysiology

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Interictal high resolution (HR-) electric source imaging (ESI) and magnetic source imaging (MSI) are non-invasive tools to aid epileptogenic zone localization in epilepsy surgery candidates. We carried out a systematic review on the diagnostic accuracy and quality of evidence of these modalities. MethodsEmbase, Pubmed and the Cochrane database were searched on 13 February 2017.Diagnostic accuracy studies taking post-surgical seizure outcome as reference standard were selected. Quality appraisal was based on the QUADAS-2 framework. ResultsEleven studies were included: eight MSI (n=267), three HR-ESI (n=127) studies. None was free of bias. This mostly involved: selection of operated patients only, interference of source imaging with surgical decision, and exclusion of indeterminate results. Summary sensitivity and specificity estimates were 82% (95% CI: 75-88%) and 53% (95% CI: 37-68%) for overall source imaging, with no statistical difference between MSI and HR-ESI. Specificity is higher when partially concordant results were included as non-concordant (p<0.05). Inclusion of indeterminate test results as non-concordant lowered sensitivity (p<0.05). ConclusionsSource imaging has a relatively high sensitivity but low specificity for identification of the epileptogenic zone. SignificanceWe need higher quality studies allowing unbiased test evaluation to determine the added value and diagnostic accuracy of source imaging in the presurgical workup of refractory focal epilepsy. Highlights Interictal source imaging studies are biased and show heterogeneity for population and test method  Source imaging sensitivity and specificity was 82% (95% CI: 75-88%) and 53% (37-68%) respectively  Diagnostic accuracy for (extra)temporal and (non)-lesional patients show no statistical differences

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“…37 Advances in surface EEG analysis have included dipole source and vector moment analyses employing inverse solution methods, which have made it possible to infer the general source of deep or medial location seizure foci. 26,31 On the other hand, the use of depth electrodes to target the medial frontal lobe surface is feasible and has similar efficacy to the placement of interhemispheric arrays. Al-though depth electrodes have a reasonable safety record in experienced hands, they are nevertheless invasive, and their complication rates multiply with the denser arrays sometime necessary for the accurate detection of medial origin foci.…”

Section: Discussionmentioning

confidence: 99%

Subdural interhemispheric grid electrodes for intracranial epilepsy monitoring: feasibility, safety, and utility

Bekelis¹,

Radwan²,

Desai³

et al. 2012

JNS

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EEG dipole source localization of interictal spikes in non-lesional TLE with and without hippocampal sclerosis

Cited by 15 publications

References 29 publications

Analysis of Interictal Epileptiform Discharges in Mesial Temporal Lobe Epilepsy Using Quantitative EEG and Neuroimaging

Analysis of Interictal Epileptiform Discharges in Mesial Temporal Lobe Epilepsy Using Quantitative EEG and Neuroimaging

Diagnostic accuracy of interictal source imaging in presurgical epilepsy evaluation: A systematic review from the E-PILEPSY consortium

Subdural interhemispheric grid electrodes for intracranial epilepsy monitoring: feasibility, safety, and utility

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