EEG burst recovery is predictive of brain injury after experimental hypothermic circulatory arrest

Pokela, Matti; Jäntti, V.; Lepola, Pasi; Romsi, Pekka; Rimpiläinen, Jussi; Kiviluoma, Kai; Salomäki, Timo; Vainionpää, Vilho; Biancari, Fausto; Hirvonen, J.; Kaakinen, Timo; Juvonen, Tatu

doi:10.1080/14017430310006956

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…Brains were fixed in 10% formalin, sliced by an automated tissue processor, and stained with hematoxylin and eosin. The double-blind approach was used, and the scoring was as follows [12]: 0 (normal): no damage. 1 (mild): slight interstitial edema or dark Eosinophilic neurons.…”

Section: Histopathological Examinationmentioning

confidence: 99%

Neuroprotective effects of Coenzyme Q10 in ischemia-reperfusion injury via inflammation and oxidative stress reduction in adult male rats

Fakharaldeen,

Al-Mudhafar,

Gany

et al. 2023

JMedLife

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This study aimed to investigate the potential neuroprotective effects of coenzyme Q10 in cerebral ischemia-reperfusion injury-induced neuronal damage and explore the underlying mechanisms. Twenty-eight adult male rats, weighing approximately 200-300 grams, were randomly divided into four groups: the sham group (neck dissection without ischemia), the control group (30 minutes of bilateral common carotid artery ligation followed by one hour of reperfusion), the vehicle group (oral carboxymethylcellulose solution for seven days prior to bilateral common carotid artery ligation and reperfusion), and the treatment group (seven days of coenzyme Q10 pretreatment followed by bilateral common carotid artery occlusion and reperfusion). Histopathological analysis and measurement of brain infarct size were performed, and cerebral levels of IL-6, IL-10, TNF-α, ICAM-1, NF-κB p65, and total antioxidant capacity were assessed. These cerebral tissue levels and cerebral infarct size were significantly elevated in the control and vehicle groups compared to the sham group. Conversely, the total antioxidant capacity was significantly reduced in these groups. Coenzyme Q10 treatment resulted in a significant increase in IL-10 and total antioxidant capacity levels, along with a significant decrease in IL-6, ICAM-1, TNF-α, and NF-κB p65 levels. Histopathological analysis revealed a significant reduction in ischemic damage in the coenzyme Q10-treated group. Coenzyme Q10 has neuroprotective properties in rats subjected to cerebral ischemia/reperfusion injury, possibly through its anti-inflammatory and anti-oxidative effects.

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Section: Histopathological Examinationmentioning

confidence: 99%

Neuroprotective effects of Coenzyme Q10 in ischemia-reperfusion injury via inflammation and oxidative stress reduction in adult male rats

Fakharaldeen,

Al-Mudhafar,

Gany

et al. 2023

JMedLife

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A Handy EEG Electrode Set for patients suffering from altered mental state

Lepola

Myllymaa

Töyräs

et al. 2015

J Clin Monit Comput

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Although electroencephalography (EEG) is an important diagnostic tool for investigating patients with unexplained altered mental state (AMS), recording of emergency EEG is not a clinical routine. This is mainly due to the cumbersome electrode solutions. A Handy EEG Electrode Set consists of ten EEG, two EOG, two ground and two commutative reference hydrogel-coated silver wire electrodes attached to a thin polyester carrier film. The clinical usefulness of the Handy EEG Electrode Set was tested in 13 patients (five females, eight males) with AMS. EEG recordings were conducted at the same time with a standard 10-20 electrode set. The registration in the first patient case without the behind-ear electrodes (T9 and T10), indicated that these electrodes are very crucial to provide clinically relevant information from posterior regions of brain. In following 12 cases, the sensitivity and specificity for detecting EEG abnormality based on the Handy EEG Electrode Set recordings were 83 and 100 %, respectively. The Handy EEG Electrode Set proved to be easy to use and to provide valuable information for the neurophysiological evaluation of a patient suffering from AMS. However, further studies with larger number of patients are warranted to clarify the true diagnostic accuracy and applicability of this approach.

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Improved Cerebral Recovery From Hypothermic Circulatory Arrest After Remote Ischemic Preconditioning

Yannopoulos

Mäkelä

Niemelä

et al. 2010

The Annals of Thoracic Surgery

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EEG burst recovery is predictive of brain injury after experimental hypothermic circulatory arrest

Abstract: A decreased EEG burst percentage seems to be associated with an increased risk of developing histologically evident brain ischemic injury in the cortex, brainstem and cerebellum after experimental HCA.

Cited by 6 publications

References 11 publications

Neuroprotective effects of Coenzyme Q10 in ischemia-reperfusion injury via inflammation and oxidative stress reduction in adult male rats

Neuroprotective effects of Coenzyme Q10 in ischemia-reperfusion injury via inflammation and oxidative stress reduction in adult male rats

A Handy EEG Electrode Set for patients suffering from altered mental state

Improved Cerebral Recovery From Hypothermic Circulatory Arrest After Remote Ischemic Preconditioning

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