Educational progress, behaviour, and motor skills at 10 years in early treated congenital hypothyroidism

Simons, W F; Fuggle, Peter; Grant, D B; Smith, I.

doi:10.1136/adc.77.3.219

Cited by 40 publications

(34 citation statements)

References 15 publications

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“…In the limited literature discussing these higher order cognitive skills, children and adolescents with CH are described as deficient in memory [2][3][4] and attention [5][6][7] compared to controls. More behavioural problems were found in terms of activity regulation 8 and internalising symptoms, 9 while one study reported no significant group differences. 3 To our knowledge, adult outcome studies have not been reported.…”

mentioning

confidence: 93%

Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour

Oerbeck

Kase²,

Heyerdahl³

2005

Archives of Disease in Childhood

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Background: In congenital hypothyroidism (CH) it has been questioned whether high dose thyroxine replacement therapy has detrimental effects on memory, attention, and behaviour. Aims: To describe memory, attention, and behaviour problems in young adults with CH, and to study possible negative effects of high dose thyroxine replacement therapy. Methods: A cohort based follow up study of 49 young adults (mean age 20 years) with early treated CH, and sibling controls (n = 41). Results: Controlled for age and sex, the CH group attained significantly lower scores than sibling controls on some tests of memory (Wechsler Logical Memory part II: 12.9 versus 17.8; difference 5.2, 95% CI 3.6 to 6.8) and attention (Wechsler Freedom From Distractibility factor: 95.6 versus 104.8; difference 9.9, 95% CI 6.4 to 13.4). They rated themselves with more behaviour problems than did sibling controls (52.7 versus 44.7; difference 27.6, 95% CI 211.2 to 24.0) on the Achenbach Self Report. A high thyroxine starting dose, high serum thyroxine treatment levels during the first six childhood years, and high levels at assessment had no adverse effects on outcome measures at age 20. On the contrary, the results suggest better outcome with higher childhood treatment levels. Conclusions: Long term outcome revealed deficits in some aspects of memory, attention, and behaviour in young adults with CH relative to sibling controls. No adverse effects of high dose thyroxine therapy were found on measures of memory, attention, and behaviour problems.

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mentioning

confidence: 93%

Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour

Oerbeck

Kase²,

Heyerdahl³

2005

Archives of Disease in Childhood

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“…However, Rovet et al (20) reported mild non-verbal learning disability in some children with CH. Recently, less satisfactory scores for educational attainments, behaviour and motor skills were reported in CH children with more severe neonatal hypothyroidism (T 4 Յ 3 mg/dl, 40 nmol/l) compared with less affected CH children (neonatal T 4 > 3 mg/dl, 40 nmol/l) (21). While differences for reading were small, deficits in mathematics were statistically significant (21).…”

Section: Discussionmentioning

confidence: 99%

“…Investigations of school attainments in CH children treated early in life have produced controversial results (19,20). School performances were found normal by the New England Congenital Hypothyroidism Collaborative (19), but mild non-verbal learning disability (20) and mild impairment in educational attainments (21) have been found in other series of early treated CH children.…”

Section: Introductionmentioning

confidence: 99%

School attainments in children with congenital hypothyroidism detected by neonatal screening and treated early in life

Bargagna

Dinetti

Pinchera

et al. 1999

European Journal of Endocrinology

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Objective: Evaluation of school attainments in children with congenital hypothyroidism (CH) detected by neonatal screening and treated early in life. Patients and methods:Text comprehension, mathematics, reading, writing and verbal and spatial memory, as indices of school learning, were evaluated in nineteen 5-to 10-year-old children with CH attending nursery or elementary school. L-Thyroxine substitution (starting dose 8-10 mg/kg body weight per day) was initiated at a mean age of 30 Ϯ 10 days of life. The control group included 298 unaffected children matched with the CH children for age and school grade. Thirty per cent of controls were classmates of CH children. Intelligence quotients (IQ), language performances and motor development were evaluated in CH children at age 5 years, and were related to their school attainments. School performances of CH children were also compared with their neonatal serum thyroxine (T 4 ) concentration, and with the social-cultural level of the family. Results: Four out of 19 (21%) children with CH, 3 in the nursery and 1 in the elementary school, displayed a generalized learning disorder. Symbol copy, geometric copy, phrase repetition, dictation writing and spontaneous writing were particularly defective in nursery school CH children, while orthographic error recognition was defective in elementary school CH children. School learning disorders in CH children were significantly correlated with a borderline-low IQ, poor language performances and a low social-cultural level of the family, but not with motor skills or neonatal T 4 concentration. Conclusion: School attainments of early treated CH children were within the normal range in most affected cases. However, about 20% of CH children, most of them attending nursery school, showed a generalized learning disorder. Low IQ scores and poor language performances at age 5 years were associated with defective learning, mainly in CH children living in a poor social-cultural environment. In this subset of CH children, prompt initiation of speech and psychomotor rehabilitation therapy is recommended in order to prevent subsequent school learning disorders.

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“…The results showed from the three Speechlanguage Pathology fields investigated, language was the one with higher number of published papers [16][17][18][19][20][21][22][23][24][25][26] . This allows the arguing about this topic in CH children to be more clear and consistent, but do not exclude the importance of other communication aspects.…”

Section: Methodsmentioning

confidence: 99%

“…Subtitles: SG= study group; CG = control group Figure 2 -Contents of localized papers about speech-language disturbances related to congenital hypothyroidism significant delay in language development [17][18][19][20][22][23][24]26 .…”

Section: Michelsson Et Al;1976 25mentioning

confidence: 99%

Alterações fonoaudiológicas em crianças com hipotireoidismo congênito: revisão crítica da literatura

et al. 2014

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Educational progress, behaviour, and motor skills at 10 years in early treated congenital hypothyroidism

Cited by 40 publications

References 15 publications

Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour

Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour

School attainments in children with congenital hypothyroidism detected by neonatal screening and treated early in life

Alterações fonoaudiológicas em crianças com hipotireoidismo congênito: revisão crítica da literatura

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