Educational Case: Squamous Cell Carcinoma of the Lung

Gálvez-Suárez, Eric; Knollmann-Ritschel, Barbara

doi:10.1177/2374289517705950

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…2a). This is consistent with human LSCC that belongs to central lung neoplasm 50 and is frequently initiated from large airways 5 . Taken together, our CCSP iCre mouse can be an efficient model for the in vivo study of lung diseases initiated from large airway and of the de novo role of these frequently mutated genes.…”

Section: Discussionsupporting

confidence: 88%

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression

et al. 2019

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Mechanisms of lung squamous cell carcinoma (LSCC) development are poorly understood. Here, we report that JNK1/2 activities attenuate Lkb1 -deficiency-driven LSCC initiation and progression through repressing ΔNp63 signaling. In vivo Lkb1 ablation alone is sufficient to induce LSCC development by reducing MKK7 levels and JNK1/2 activities, independent of the AMPKα and mTOR pathways. JNK1/2 activities is positively regulated by MKK7 during LSCC development. Pharmaceutically elevated JNK1/2 activities abates Lkb1 dependent LSCC formation while compound mutations of Jnk1/2 and Lkb1 further accelerate LSCC progression. JNK1/2 is inactivated in a substantial proportion of human LSCC and JNK1/2 activities positively correlates with survival rates of lung, cervical and head and neck squamous cell carcinoma patients. These findings not only determine a suppressive role of the stress response regulators JNK1/2 on LSCC development by acting downstream of the key LSCC suppresser Lkb1 , but also demonstrate activating JNK1/2 activities as a therapeutic approach against LSCC.

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Section: Discussionsupporting

confidence: 88%

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression

et al. 2019

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“…Lung squamous cell carcinoma is a common histological type in male non-small cell lung cancer. At present, the basic and clinical research of lung squamous cell carcinoma is still lagging behind, and no specific targeted preparation has been found [ 16 ]. Therefore, it is of great clinical significance to study the molecular mechanism of invasion and metastasis of lung squamous cell carcinoma and explore specific targeted therapeutic molecules related to prognosis.…”

Section: Discussionmentioning

confidence: 99%

TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin

Chen

et al. 2020

Aging

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Lung squamous cell carcinoma (LSCC) is the most common histological type of primary lung cancer. In this study, we had tested the biological role of TRIM29 in LSCC cells. TRIM29 abundance, the relationships between TRIM29 and E-cadherin and autophagy degradation related proteins in clinical tissues and six cell lines were studied with quantitative real-time PCR test (qRT-PCR) and western blot. TRIM29 overexpression treated HTB-182 cells and knockdown treated NCL-H1915 cells was used for studying cell proliferation, colony formation, migration, invasion, and the expression of epithelial mesenchymal transformation (EMT) associated biomarkers. The relationships between TRIM29 and BECN1 were investigated with western blot. TRIM29 was profoundly overexpressed in LSCC tissues and cells compared with human normal bronchial epithelial cells (HNBE). High TRIM29 expression was closely related to overall survival (OS). TRIM29 overexpression and knockdown affected LSCC activity and the expression of EMT associated biomarkers. TRIM29 can regulate the degradation of E-cadherin and autophagy of LSCC through BECN1 gene, and promote autophagy in HTB-182 and NCL-H1915 cells. Our results revealed that TRIM29 could promote the proliferation, migration, and invasion of LSCC via E-cadherin autophagy degradation. The results are useful for further study in LSCC.

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“…The contribution of each cell to the ADC/SCC classification was calculated (detailed in the Methods) and depicted in Figure 2D-E. Notably, regions with sheets of polygonal cells contributed to SCC classification, reflecting the histopathological feature of the SCC subtype (23). As a result, the celllevel contribution heatmap effectively highlights typical cell organization patterns for ADC and SCC.…”

Section: Understanding the Prediction Mechanism Of Ceographmentioning

confidence: 99%

Deep Learning of Cell Spatial Organizations Identifies Clinically Relevant Insights in Tissue Images

Xiao

Wang

Rong

et al. 2023

Preprint

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Recent advancements in tissue imaging techniques have facilitated the visualization and identification of various cell types within physiological and pathological contexts. Despite the emergence of cell-cell interaction studies, there is a lack of methods for evaluating individual spatial interactions. In this study, we introduce Ceograph, a novel cell spatial organization-based graph convolutional network designed to analyze cell spatial organization (i.e. the cell spatial distribution, morphology, proximity, and interactions) derived from pathology images. Ceograph identifies key cell spatial organization features by accurately predicting their influence on patient clinical outcomes. In patients with oral potentially malignant disorders, our model highlights reduced structural concordance and increased closeness in epithelial substrata as driving features for an elevated risk of malignant transformation. In lung cancer patients, Ceograph detects elongated tumor nuclei and diminished stroma-stroma closeness as biomarkers for insensitivity to EGFR tyrosine kinase inhibitors. With its potential to predict various clinical outcomes, Ceograph offers a deeper understanding of biological processes and supports the development of personalized therapeutic strategies.

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Educational Case: Squamous Cell Carcinoma of the Lung

Cited by 7 publications

References 1 publication

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression

TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin

Deep Learning of Cell Spatial Organizations Identifies Clinically Relevant Insights in Tissue Images

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