Editorial The role of monoamines in modulating behavior

Swallow, John G.; Bubak, Andrew N.; Grace, Jaime L.

doi:10.1093/cz/zow046

Cited by 7 publications

(6 citation statements)

References 16 publications

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“…Unfortunately, given the small extractable volume from each rat (∼150 μL) we were unable to obtain a CSF pool large enough to allow proper electrophysiological experimentation. Since neuromodulatory systems architecture is known to be well conserved across species ( O’Connell, 2013 ; Swallow et al, 2016 ; Lovett-Barron et al, 2017 ), we would expect hCSF to produce similar effects on human hippocampal and cortical neurons. In line with this prediction, a recent study using human neocortical brain slices prepared from resected tissue of epilepsy patients reported that hCSF, as compared to artificial culturing media, enhanced neuronal activity ( Schwarz et al, 2017 ).…”

Section: Recent In Vitro Findings With Human Cerebmentioning

confidence: 99%

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Björefeldt

Illes

Zetterberg

et al. 2018

Front. Neural Circuits

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The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits in vivo via volume transmission. Recent in vitro experimental work in brain slices and neuronal cultures has shown that human CSF indeed contains neuromodulators that strongly influence neuronal activity. Here we briefly summarize these new findings and discuss their potential relevance to neural circuits in health and disease.

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Section: Recent In Vitro Findings With Human Cerebmentioning

confidence: 99%

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Björefeldt

Illes

Zetterberg

et al. 2018

Front. Neural Circuits

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“…The dopaminergic and serotonergic systems play fundamental roles in explaining behavioural variation (Winberg and Nilsson 1993 ; Swallow et al 2016 ), and so could be expected to underlie variation in learning, cognitive flexibility, and optimism. The dopaminergic system is involved in establishing and strengthening associations between stimulus and reward (Shultz et al 1997 ; Frank et al 2004 ).…”

Section: Introductionmentioning

confidence: 99%

The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks

et al. 2020

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Intra-species cognitive variation is commonly observed, but explanations for why individuals within a species differ in cognition are still understudied and not yet clear. Cognitive processes are likely influenced by genetic differences, with genes in the monoaminergic systems predicted to be important. To explore the potential role of these genes in association with individual variation in cognition, we exposed red junglefowl (Gallus gallus) chicks to behavioural assays measuring variation in learning (discriminative learning, reversal learning, and cognitive flexibility) and optimism (measured in a cognitive judgement bias test). Following this, we analysed prefrontal cortex gene expression of several dopaminergic and serotonergic genes in these chicks. Of our explored genes, serotonin receptor genes 5HT2A and 5HT2B, and dopaminergic receptor gene DRD1 were associated with measured behaviour. Chicks that had higher 5HT2A were less flexible in the reversal learning task, and chicks with higher 5HT2B also tended to be less cognitively flexible. Additionally, chicks with higher DRD1 were more optimistic, whilst chicks with higher 5HT2A tended to be less optimistic. These results suggest that the serotonergic and dopaminergic systems are linked to observed cognitive variation, and, thus, individual differences in cognition can be partially explained by variation in brain gene expression.

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“…Monoaminergic neuromodulators have important roles in the regulation of different physiological and behavioral processes, both in vertebrates and invertebrates. This includes learning and memory, wakefulness and arousal, stress responses, social interactions, and aggression, among others ( Swallow et al, 2016 ; Ranjbar-Slamloo and Fazlali, 2020 ). Recent studies have shown that brain monoamines might be important in regulating interspecific patterns of behavior such as those between cleaner fish and their clients ( Soares, 2017 ; de Abreu et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Cohabitation With Atlantic Salmon (Salmo salar) Affects Brain Neuromodulators But Not Welfare Indicators in Lumpfish (Cyclopterus lumpus)

et al. 2022

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Lumpfish are utilized to combat ectoparasitic epidemics in salmon farming. Research gaps on both cleaning behavior and client preferences in a natural environment, emphasizes the need to investigate the physiological impacts on lumpfish during cohabitation with piscivorous Atlantic salmon. Lumpfish (39.9 g, S.D ± 8.98) were arranged in duplicate tanks (n = 40 per treatment) and exposed to Live Atlantic salmon (245.7 g, S.D ± 25.05), salmon Olfaction or lifelike salmon Models for 6 weeks. Growth and health scores were measured every second week. In addition, the final sampling included measurements of neuromodulators, body color, and plasma cortisol. A stimulation and suppression test of the hypothalamic-pituitary-interrenal (HPI) axis was used for chronic stress assessment. Results showed that growth, health scores, and body color remained unaffected by treatments. Significant reductions in levels of brain dopamine and norepinephrine were observed in Live compared to Control. Plasma cortisol was low in all treatments, while the stimulation and suppression test of the HPI axis revealed no indications of chronic stress. This study presents novel findings on the impact on neuromodulators from Atlantic salmon interaction in the lumpfish brain. We argue that the downregulation of dopamine and norepinephrine indicate plastic adjustments to cohabitation with no negative effect on the species. This is in accordance with no observed deviations in welfare measurements, including growth, health scores, body color, and stress. We conclude that exposure to salmon or salmon cues did not impact the welfare of the species in our laboratory setup, and that neuromodulators are affected by heterospecific interaction.

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Editorial The role of monoamines in modulating behavior

Cited by 7 publications

References 16 publications

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks

Cohabitation With Atlantic Salmon (Salmo salar) Affects Brain Neuromodulators But Not Welfare Indicators in Lumpfish (Cyclopterus lumpus)

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