Editorial – preview

Schrempf, Hildgund; Dyson, Paul

doi:10.1111/j.1751-7915.2011.00255.x

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Streptomycetes, a group of actinomycetes, are a major source for a repertoire of small molecules that function as antibiotics, antiparasitics, antitumor, antifungals and/or immunosuppressive drugs. 13 During the synthesis of b-Au NPs, some of these anticancer molecules may conjugate with these nanoparticles or may functionalize themselves on the nanoparticle surface to form in situ drug delivery systems. The cell-free supernatant of Streptomyces clavuligerus strain ICTA567 was added to an aqueous hydrogen tetrachloroaurate solution at 100 °C to generate gold nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway)

2015

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The physiochemical and biological properties of microbial derived gold nanoparticles have potential applications in various biomedical domains as well as in cancer therapy. We have fabricated anti-proliferative bacterial mediated gold nanoparticles (b-Au NPs) using a culture supernatant of Streptomyces clavuligerus and later characterized them by UV-visible, TEM, DLS, XRD and FT-IR spectroscopic techniques. The capping agent responsible for the nanoparticle formation was characterized based on SDS-PAGE and MALDI-TOF-MS analyses. They were tested for anticancer activity in A549, HeLa and DU145 cell lines. The biocompatibility and non-toxic nature of the nanoparticles were tested on normal human lung cell line (MRC-5). The b-Au NPs induced the cell cycle arrest in G2/M phase and also inhibited the microtubule assembly in DU145 cells. Mechanistic studies, such as ROS, MMP, Cyt-c, GSH, caspases 9, 8 and 3 activation and the Annexin V-FITC staining, along with the above parameters tested provided sufficient evidence that the b-Au NPs induced apoptosis through the intrinsic pathway. The results supported the use of b-Au NPs for future therapeutic application in cancer therapy and other biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway)

2015

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“…As for the chemically synthesised NPs, promising results were obtained for PC imaging and targeting after being functionalised with specific anti-PSMA antibodies. This was manifested by generating specific MR imaging probes for targeted imaging of PC cells from J591 antibody functionalised SPIONS [145], MLN591 antibody coated iron oxide NPs [146], muJ591 antibody coated iron oxide NPs [147], and 64 Cu-DOTA-J591scFv-Lipid NPS (LNPs) [148]. Moreover, a case of the PSMA-targeting polypeptide, CQKHHNYLC, conjugated to SPIONs demonstrated specific uptake by PSMA-expressing cells in vitro/in vivo [149].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Upgrading gold to green nanoparticles: applications in prostate cancer

Mitri¹,

Rahme²,

Fracasso³

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Green nanotechnology produces biocompatible gold nanoparticles (AuNPs) with intrinsic anti-microbial, anti-viral, and anti-tumour properties. Green AuNPs (g-AuNPs) are gaining a solid ground in prostate cancer (PC) nanotherapy. Hence, in this review, we summarise and compare data from studies published between 2015 and 2022 to highlight major biological compounds and outputs from in vitro and in vivo applications of green or biosynthesised AuNPs in PC theranostics. In fact, g-AuNPs can be easily generated with effective antiproliferative PC characteristics. Taken together, g-AuNPs exert various apoptosis-related mechanisms, such as reactive oxygen species (ROS) generation, cell cycle arrest, cytotoxicity, mitochondrial disruption, and anti-tumour immune cell activation, with additional successful delivery of the biological compounds in green materials. g-AuNPs could offer another modality for targeted cancer therapy using antibodies and targeting ligands to specifically recognise and destroy PC tumours. In conclusion, g-AuNPs applications drive forth sustainable nanotechnology while minimising ethical concerns and toxicity risks in clinical trials.

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Editorial – preview

Cited by 2 publications

References 16 publications

Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway)

Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway)

Upgrading gold to green nanoparticles: applications in prostate cancer

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