Editorial: Occupational exposure and cardiometabolic disorders

Qin, Kun; Jia, Peng

doi:10.3389/fpubh.2023.1171033

Cited by 1 publication

(1 citation statement)

References 9 publications

(10 reference statements)

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“…According to the diagnosis criteria of Adult Treatment Panel III (ATP-III) 2 , MetS is usually defined as the presence of three or more of the five common metabolic dysfunctions, i.e., elevated waist circumference (WC), elevated triglycerides (TG), reduced high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and elevated fasting blood glucose (FBG). However, such a dichotomous definition for MetS, although helpful to identify certain populations at disproportionate future risk for CVDs 5 , 6 , cannot reflect the severity of MetS, which has challenged its applications in tracking the progression of CVD risk and hence preventing CVDs. Previous studies have developed a continuous MetS score in western countries to determine the MetS severity, which was considered a compelling means of motivating patients that may feel empowered by a decrease in score 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults

Yang,

Yu,

et al. 2023

Nat Commun

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Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethnicity-specific MetS score based on continuous measures of the five metabolic dysfunctions (waist circumference [WC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], mean arterial pressure [MAP], and fasting blood glucose [FBG]). We find that the weights of metabolic dysfunctions in the score vary across age-sex-ethnicity-specific subgroups, with higher weights for TG, HDL-C, and WC. Each unit increase in the score is associated with increased risks for hyperlipidemia, diabetes, and hypertension, and elevated levels of HbA1c, cholesterol, body mass index, and serum uric acid. The score shows high sensitivity and accuracy for detecting CVD-related risk factors and is validated in different geographical regions. Our study would advance early identification of CVD risks and, more broadly, preventive medicine and sustainable development goals.

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