Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults

Abstract

Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethnicity-specific MetS score based on continuous measures of the five metabolic dysfunctions (waist circumference [WC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], mean arterial pressure [MAP], and fasting blood glucose [FBG]). We find that the weights of metabolic dysfunctions in the score vary across age-sex-ethnicity-specific subgroups, with higher weights for TG, HDL-C, and WC. Each unit increase in the score is associated with increased risks for hyperlipidemia, diabetes, and hypertension, and elevated levels of HbA1c, cholesterol, body mass index, and serum uric acid. The score shows high sensitivity and accuracy for detecting CVD-related risk factors and is validated in different geographical regions. Our study would advance early identification of CVD risks and, more broadly, preventive medicine and sustainable development goals.

Long-term exposure to PM2.5 chemical constituents and diabesity: evidence from a multi-center cohort study in China

“…1 ). 15 A multi-stage cluster random sampling method, adopted by the Chinese Center for Disease Prevention and Control to carry out the national Chronic Disease and Risk Factor Surveillance, 16 , 17 was used to recruit participants from the general population in selected communities, which were chosen from each of the selected districts/counties in three provinces. Participants were invited to participate in the surveys if meeting all following inclusion criteria: 1) being aged 18 or older on the day of the survey; 2) living in the selected communities for more than three years; and 3) not having severe mental illnesses, such as paraplegia, schizophrenia, and terminal illnesses.…”

“…As a result, the Fujian Behavior and Disease Surveillance Cohort (FBDS) was established during 2018–2020, recruiting 54,961 adults aged >18 years from 29 districts/counties of the province, with a participation rate of 85%–92%; the Hubei Behavior and Disease Surveillance Cohort (HBDS) was established during 2018–2020, recruiting 27,962 adults aged >18 years from 10 districts/counties of the province, with a participation rate of 91%; and the Yunnan Behavior and Disease Surveillance Cohort (YBDS) was established from January to August 2021, recruiting 51,480 adults aged >18 years from 35 districts/counties of the province, with a participation rate of 99.7%. 15

Fig. 1 Distributions of the study participants and the 3-year average PM 2.5 concentrations in three provinces.

…”

Long-term Metabolic Side Effects of Second-Generation Antipsychotics in Chinese Patients with Schizophrenia: A Within-Subject Approach with modelling of dosage effects

“…Notably, many previous studies in SGAs' effects were conducted in European populations, and rarely on Asian/Chinese settings. Given the difference in baseline BMI and metabolic profiles between Asian and European populations [24][25][26][27], it is valuable to study SGAs' effects using a Chinese sample.…”

The Impact of Metabolic Syndrome Severity on Frailty Progression among Chinese middle and old-aged adults: A Longitudinal Study

“…Additionally, the binary classi cation of MetS failed to accurately re ect the severity of metabolic disturbances and overlooked differences in race, sex, and age, leading to inadequate capture of the subtle variations in the progression of MetS. To address these issues, Yang et al developed an age-sex-racespeci c MetS scoring system(Met Score) for the Chinese population (19). This system quanti es the severity of MetS by reweighting ve common metabolic disorder factors-triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), waist circumference (WC), and mean arterial pressure (MAP)-and has been validated in three large population samples for its effectiveness in predicting adverse outcomes associated with MetS.…”