Editorial (Nutriproteomics and Proteogenomics: Cultivating Two Novel Hybrid Fields of Personalized Medicine with Added Societal Value)

Özdemir, Vural; Armengaud, Jean; Dubé, Laurette; Aziz, Ramy K.; Knoppers, Bartha Maria

doi:10.2174/187569210793368230

Cited by 11 publications

(10 citation statements)

References 27 publications

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“…An extension of item 7b of the CONSORT Statement could be one concrete mechanism to remedy this gap in policies concerning the reporting of clinical trial data, and how interim analyses are carried out. This would also cultivate foresight for policies on how best to utilize other emerging types of biomarker data other than genomics (e.g., proteomics) for inefficacy monitoring (Ozdemir et al 2010).…”

Section: Discussionmentioning

confidence: 99%

ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT Statement?

Özdemir

Joly

Knoppers

2011

The American Journal of Bioethics

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Section: Discussionmentioning

confidence: 99%

ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT Statement?

Özdemir

Joly

Knoppers

2011

The American Journal of Bioethics

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“…While nutrigenetics addresses how an individual's genetic makeup predisposes for dietary susceptibility, nutrigenomics can be defined as the study of the effects of foods and food components on gene expression. Nutritional proteomics or nutriproteomics is a new field that involves the characterization and quantification of food-derived bioactive peptides and proteins for discerning the mechanisms by which proteome variation impacts nutrition-related health outcomes (Ozdemir et al, 2010). Specifically, nutriproteomics provides two essential avenues for molecular nutrition research and applications in personalized nutrition: (a) the characterization and quantification of food-derived bioactive peptides and proteins and (b) the elucidation of biomarkers for mechanism-of-action, efficacy, and side effects of nutritional interventions.…”

Section: Nutriproteomicsmentioning

confidence: 99%

Proteomics in Food Science

Gallardo

Carrera

Ortea³

2013

Foodomics

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“…are being replaced with ''How can a new technology and its applications be co-designed and governed collaboratively early on, together with innovators and anticipated end-users?'' (Ozdemir et al, 2010). This signals an upstream shift for shared (and anticipatory) governance at the stage of technology design before its applications enter society.…”

Section: Expertise and Lay Knowledge: Contested And Fluid Boundariesmentioning

confidence: 99%

“…Such recognition is necessary to steer innovations and emerging technologies in a manner that is closely attuned to social values (Einsiedel, 2011;Gaskell et al, 2005;Lehoux, 2011). Ultimately, this serves to integrate scientific and social knowledge thereby steering innovations to coproduce results and outputs that are socially robust and context sensitive (Ozdemir et al, 2010(Ozdemir et al, , 2011b.…”

Section: Future Promises and Caveatsmentioning

confidence: 99%

“…Indeed, the success of knowledgebased innovations such as vaccinomics is not only contingent on access to new biotechnologies. It also requires new ways of governance of science, knowledge production, and management (Bell and Hindmoor, 2009;Carlile, 2004;Cook and Brown, 1999;Faraj and Yan, 2009;Huzair et al, 2011;Ozdemir et al, 2010Ozdemir et al, , 2011a. It demands an understanding of the ways in which science-technology-society are interwoven in coproduction of knowledge on a day-to-day basis (Bijker et al, 1987;Faraj et al, 2004;Jasanoff, 2006;Ozdemir et al, 2011b;Ravetz, 1971;Yearley, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Steering Vaccinomics Innovations with Anticipatory Governance and Participatory Foresight

Özdemir

Faraj

Knoppers

2011

OMICS: A Journal of Integrative Biology

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Vaccinomics is the convergence of vaccinology and population-based omics sciences. The success of knowledge-based innovations such as vaccinomics is not only contingent on access to new biotechnologies. It also requires new ways of governance of science, knowledge production, and management. This article presents a conceptual analysis of the anticipatory and adaptive approaches that are crucial for the responsible design and sustainable transition of vaccinomics to public health practice. Anticipatory governance is a new approach to manage the uncertainties embedded on an innovation trajectory with participatory foresight, in order to devise governance instruments for collective "steering" of science and technology. As a contrast to hitherto narrowly framed "downstream impact assessments" for emerging technologies, anticipatory governance adopts a broader and interventionist approach that recognizes the social construction of technology design and innovation. It includes in its process explicit mechanisms to understand the factors upstream to the innovation trajectory such as deliberation and cocultivation of the aims, motives, funding, design, and direction of science and technology, both by experts and publics. This upstream shift from a consumer "product uptake" focus to "participatory technology design" on the innovation trajectory is an appropriately radical and necessary departure in the field of technology assessment, especially given that considerable public funds are dedicated to innovations. Recent examples of demands by research funding agencies to anticipate the broad impacts of proposed research--at a very upstream stage at the time of research funding application--suggest that anticipatory governance with foresight may be one way how postgenomics scientific practice might transform in the future toward responsible innovation. Moreover, the present context of knowledge production in vaccinomics is such that policy making for vaccines of the 21st century is occurring in the face of uncertainties where the "facts are uncertain, values in dispute, stakes high and decisions urgent and where no single one of these dimensions can be managed in isolation from the rest." This article concludes, however, that uncertainty is not an accident of the scientific method, but its very substance. Anticipatory governance with participatory foresight offers a mechanism to respond to such inherent sociotechnical uncertainties in the emerging field of vaccinomics by making the coproduction of scientific knowledge by technology and the social systems explicit. Ultimately, this serves to integrate scientific and social knowledge thereby steering innovations to coproduce results and outputs that are socially robust and context sensitive.

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Editorial (Nutriproteomics and Proteogenomics: Cultivating Two Novel Hybrid Fields of Personalized Medicine with Added Societal Value)

Cited by 11 publications

References 27 publications

ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT Statement?

ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT Statement?

Proteomics in Food Science

Steering Vaccinomics Innovations with Anticipatory Governance and Participatory Foresight

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