Editorial: MicroRNAs in endocrinology and cell signaling

Peng, Chun; Li, Julang

doi:10.3389/fendo.2022.1118426

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…In addition to the NCCs, miRNAs are involved in the activity of the endocrine system and regulate hormone production, activity and responsiveness of target cells. They can directly act on target genes encoding hormones or enzymes involved in hormone production or metabolism, thus affecting hormone concentrations (Peng and Wang, 2018;Peng and Li, 2022). For example, miRNA-21, miRNA-let-7, miRNA-16 and miRNA-24 are among the miRNAs involved in various parasitic diseases (see Table 1 for references), as well as possible neuroendocrine cell function (Park, 2017).…”

Section: Hypothesis On the Possible Role Of Endoparasites In The Proc...mentioning

confidence: 99%

The Parasite-Mediated Domestication Hypothesis

Skok

2023

agricsci

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Based on the premise that parasites indirectly influence literally all of the main processes that otherwise underlie the domestication syndrome, it is hypothesised here that endoparasites (helminths and protozoa) have played an important mediating role in the process of (proto)domestication. The hypothesis predicts that the frequency of domestication syndrome traits such as tameness, depigmentation, mottling, piebaldism, floppy ears, short and curled tail, reduced size of the adrenal gland, etc. in the (wild) population increases i) with decreasing genetic resistance to parasites and/or ii) with increasing parasite load. According to the parasite-mediated domestication hypothesis, the features of the domestication syndrome could be genetically linked to genes related to resistance/tolerance to parasites, the role of miRNA in the process of epigenetic inheritance or the transgenerational inheritance of stress pathology.

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Section: Hypothesis On the Possible Role Of Endoparasites In The Proc...mentioning

confidence: 99%

The Parasite-Mediated Domestication Hypothesis

Skok

2023

agricsci

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“…Over the past decades, it has been demonstrated that miRNAs can regulate hormone production, activity, and target cell responsiveness ( Peng and Wang, 2018 ). For instance, miRNAs can directly target genes encoding hormones or enzymes involved in hormone production or metabolism, affecting hormone concentrations; and proteins that modulate hormone actions, such as antagonists, can also be regulated by miRNAs; also, many studies have demonstrated that hormones regulate miRNAs, and such regulation can occur at the level of transcription or processing resulting in a complex regulatory network that ultimately impacts cell homeostasis ( Peng and Li, 2022 ). Moreover, miRNAs can target hormone receptors and intracellular signaling molecules to alter target cell responses ( Derghal et al, 2016 ; Bayraktar et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

et al. 2023

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MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression at the post-transcriptional level either by translational inhibition or mRNA degradation and have recently been importantly related to the diagnosis and prognosis of the most relevant endocrine disorders. The endocrine system comprises various highly vascularized ductless organs regulating metabolism, growth and development, and sexual function. Endocrine disorders constitute the fifth principal cause of death worldwide, and they are considered a significant public health problem due to their long-term effects and negative impact on the patient’s quality of life. Over the last few years, miRNAs have been discovered to regulate various biological processes associated with endocrine disorders, which could be advantageous in developing new diagnostic and therapeutic tools. The present review aims to provide an overview of the most recent and significant information regarding the regulatory mechanism of miRNAs during the development of the most relevant endocrine disorders, including diabetes mellitus, thyroid diseases, osteoporosis, pituitary tumors, Cushing’s syndrome, adrenal insufficiency and multiple endocrine neoplasia, and their potential implications as disease biomarkers.

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Editorial: MicroRNAs in endocrinology and cell signaling

Cited by 2 publications

References 29 publications

The Parasite-Mediated Domestication Hypothesis

The Parasite-Mediated Domestication Hypothesis

Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

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