Editorial: Intestinal Dysbiosis in Inflammatory Diseases

Oliveira, Gislane Lelis Vilela de; Cardoso, Cristina Ribeiro de Barros; Taneja, Veena; Fasano, Alessio

doi:10.3389/fimmu.2021.727485

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…and de Oliveira et al. studied the role of intestinal dysbiosis and nutrition in the context of inflammatory diseases such as rheumatoid arthritis (RA) ( 77 , 78 ). These studies demonstrated the intricate connections between the gut microbiome, dietary patterns, and systemic inflammation, emphasizing the potential link between diet-induced microbial changes and the pathogenesis of RA.…”

Section: Immune Dysregulation and The Microbiomementioning

confidence: 99%

Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review

Warren,

Nyavor,

Beguelin

et al. 2024

Front. Immunol.

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More than 20% of American adults live with a mental disorder, many of whom are treatment resistant or continue to experience symptoms. Other approaches are needed to improve mental health care, including prevention. The role of the microbiome has emerged as a central tenet in mental and physical health and their interconnectedness (well-being). Under normal conditions, a healthy microbiome promotes homeostasis within the host by maintaining intestinal and brain barrier integrity, thereby facilitating host well-being. Owing to the multidirectional crosstalk between the microbiome and neuro-endocrine-immune systems, dysbiosis within the microbiome is a main driver of immune-mediated systemic and neural inflammation that can promote disease progression and is detrimental to well-being broadly and mental health in particular. In predisposed individuals, immune dysregulation can shift to autoimmunity, especially in the presence of physical or psychological triggers. The chronic stress response involves the immune system, which is intimately involved with the gut microbiome, particularly in the process of immune education. This interconnection forms the microbiota-gut-immune-brain axis and promotes mental health or disorders. In this brief review, we aim to highlight the relationships between stress, mental health, and the gut microbiome, along with the ways in which dysbiosis and a dysregulated immune system can shift to an autoimmune response with concomitant neuropsychological consequences in the context of the microbiota-gut-immune-brain axis. Finally, we aim to review evidenced-based prevention strategies and potential therapeutic targets.

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Section: Immune Dysregulation and The Microbiomementioning

confidence: 99%

Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review

Warren,

Nyavor,

Beguelin

et al. 2024

Front. Immunol.

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“…A shift from a balanced ecosystem or the dysbiotic ecosystem could be attributed to diet and lifestyle alterations ( Ghosh et al, 2013 ), age ( Mariat et al, 2009 ), obesity ( Magne et al, 2020 ), circadian rhythm ( Thaiss et al, 2014 , 2015 ), and disease pathologies, including cancer ( Sheflin et al, 2014 ; Biragyn and Ferrucci, 2018 ), cardiovascular disorder ( Lau et al, 2017 ), immune dysfunction ( de Oliveira et al, 2021 ), and several psychological illnesses ( Sarkar et al, 2018 ; Parker et al, 2020 ). For instance, a reduced alpha diversity of gut microbiota was found in young adults (mean age: ~13 years) with attention-deficit hyperactivity disorder (ADHD).…”

Section: Microbial Ecosystem: Diversity Profile and Disease Pathogenesismentioning

confidence: 99%

Metabolites: a converging node of host and microbe to explain meta-organism

Chakraborty

2024

Front. Microbiol.

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Meta-organisms encompassing the host and resident microbiota play a significant role in combatting diseases and responding to stress. Hence, there is growing traction to build a knowledge base about this ecosystem, particularly to characterize the bidirectional relationship between the host and microbiota. In this context, metabolomics has emerged as the major converging node of this entire ecosystem. Systematic comprehension of this resourceful omics component can elucidate the organism-specific response trajectory and the communication grid across the ecosystem embodying meta-organisms. Translating this knowledge into designing nutraceuticals and next-generation therapy are ongoing. Its major hindrance is a significant knowledge gap about the underlying mechanisms maintaining a delicate balance within this ecosystem. To bridge this knowledge gap, a holistic picture of the available information has been presented with a primary focus on the microbiota-metabolite relationship dynamics. The central theme of this article is the gut-brain axis and the participating microbial metabolites that impact cerebral functions.

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“…In this regard, microbiota is heterogeneous and can be divided into two large groups, a beneficial tolerogenic (immunoregulatory) microbiota and potentially harmful inflammatory opportunistic microbiota [59]. The tolerogenic microbiota fulfills dietary fiber fermentation and produces seven short-chain fatty acids: butyrate, propionate, acetate, formate, isobutyrate, valerate, and isovalerate, which are essential factors along with pro-tolerogenic neurotransmitters and neuropeptides for the proliferation and maturation of TDCs and pTreg cells and for the enterocytes and colonocytes regeneration due to the renewal of intestinal stem cells and inhibition of the Th1, Th2 and Th17 lymphocytes activity [60,61]. Interestingly, the many bacteria of the first group synthesize neuro molecules, serotonin, GABA, opioids, dopamine, required for the immunoregulation in the gut and interaction with the immune and nervous systems [62,63].…”

Section: The Gut Microbiotamentioning

confidence: 99%

“…In the ENIS framework, the tolerogenic microbiota implements a unique role [61] in deterrence of the opportunistic bacteria growth and generation of metabolites and neuro molecules for TDCs and pTregs proliferation without which the gut and the whole body cannot exist since there are many other forms of gastrointestinal activity and gut-based vital functions.…”

Section: Integrity Of the Gastrointestinal Barriersmentioning

confidence: 99%

Food Allergies: New Challenges of Our Civilization

Klimov¹,

Cherevko²,

Koshkarova³

et al. 2023

Allergic Disease - New Developments in Diagnosis and Therapy

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People need to eat and digest food, and if they encounter a food allergy it is a real problem. Moreover, some people have a lifelong sensitization to certain products with the threat of anaphylaxis. This chapter considers different aspects of food allergies, allergenicity of dietary allergens, the significance of the gut microbiota and intestinal epithelium integrity, detailed processes of food sensitization, clinical phenotypes and management of food allergies, and, finally, mechanisms of oral tolerance. Fortunately, the gastrointestinal tract possesses robust tolerogenic mechanisms, in particular, the beneficial gut microbiota, as well as the autonomous enteric nervous system, which taken together with the gut immune cells and molecules may be called the enteric neuroimmune system (ENIS). The dual-allergen exposure hypothesis postulates that early oral exposure to food allergens induces tolerance, whereas exposure at non-gastrointestinal sites results in food sensitization and allergy development. In addition, a series of food allergic episodes does not look like a typical atopic disease and is a known exception to the rule conceived by evolution. However, the prevalence of food allergies is continuously growing, including severe cases, and it is a paradoxical problem in the face of evolution. This challenge is inherent to our civilization and will be resolved, thanks to new knowledge and technologies.

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Editorial: Intestinal Dysbiosis in Inflammatory Diseases

Cited by 11 publications

References 36 publications

Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review

Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review

Metabolites: a converging node of host and microbe to explain meta-organism

Food Allergies: New Challenges of Our Civilization

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