Editorial. Induction chemotherapy for advanced head and neck cancer

Hong, Waun Ki

doi:10.1002/hed.2890100302

Cited by 11 publications

(5 citation statements)

References 10 publications

(4 reference statements)

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“…In the last five decades, chemotherapy has been used as an adjuvant treatment for OSCCs prior to the surgical excision of the cancer in order to improve the resectability of large OSCCs and the survival rate of the OSCC patients. 4 , 5 , 6 , 7 , 8 In some institutions, including the Department of Dentistry, National Taiwan University Hospital (NTUH), adjuvant chemotherapy has been frequently included in the treatment protocol for previously-untreated OSCC. 7 It has been proved that chemotherapy can do so by exerting certain cytotoxic effects on the cancer cells to reduce the OSCC size.…”

Section: Introductionmentioning

confidence: 99%

“… 4 , 5 , 6 , 7 , 8 In some institutions, including the Department of Dentistry, National Taiwan University Hospital (NTUH), adjuvant chemotherapy has been frequently included in the treatment protocol for previously-untreated OSCC. 7 It has been proved that chemotherapy can do so by exerting certain cytotoxic effects on the cancer cells to reduce the OSCC size. However, the mechanisms involved in this process remain unexplored.…”

Section: Introductionmentioning

confidence: 99%

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Comparisons of histological features among primary oral squamous cell carcinomas before and after adjuvant chemotherapy and their lymph node metastatic cancer lesions after adjuvant chemotherapy

Cheng

Wang

et al. 2022

Journal of Dental Sciences

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Background/purpose Adjuvant chemotherapy has been used to control the primary oral squamous cell carcinoma (OSCC) size prior to surgical excision of the cancer. This study aimed to explore the histological changes of primary OSCCs and their cervical lymph node metastatic cancer lesions after chemotherapy. Materials and methods Thirty-three OSCC patients with eleven having cervical lymph node metastases received adjuvant chemotherapy before surgical excision of their cancer lesions. Hematoxylin and eosin-stained tissue sections of incisional biopsy, surgical excision, and cervical lymph node metastatic cancer lesion specimens were compared microscopically to observe the histological changes in the cancer tissues after chemotherapy. Results Common histological features could be found in the primary OSCCs and their cervical lymph node metastatic cancer lesions after chemotherapy. These included direct killing of cancer cells by chemotherapeutic agents, resulting in cancer cell necrosis and degeneration in the early phase, and squamous and keratinizing metaplasia of drug-induced cancer cells, leading to individual cell keratinization and keratin pearl formation in the later phase. There were also small nests of drug-resistant proliferating cancer cells in the inflamed fibrous connective tissue stroma. The most characteristic histological feature in the metastatic lymph nodes after chemotherapy was the keratinizing metaplasia of the metastatic cancer cells, resulting in the formation of epidermoid cyst-like lesions. Conclusion Although the cancer reduces its size after chemotherapy, residual cancer cells are consistently present in the primary OSCC lesions after chemotherapy. Therefore, wide surgical resection of the cancer is still needed to ensure the complete removal of all cancer tissues.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparisons of histological features among primary oral squamous cell carcinomas before and after adjuvant chemotherapy and their lymph node metastatic cancer lesions after adjuvant chemotherapy

Cheng

Wang

et al. 2022

Journal of Dental Sciences

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“…Its place has been reviewed by several authors (Cachin, 1982;Chang, 1988;Forestiere, 1986;Glick & Taylor, 1981;Hong, 1988;Mead & Jacobs, 1982;Tannock & Browman, 1986) who have mostly concluded that adjuvant chemotherapy does not show any survival benefit compared with conventional surgery or radiotherapy. However, a review must satisfy certain criteria before we can accept its findings.…”

mentioning

confidence: 99%

“…Most of the above papers review only some of the reported papers. For example, one review of induction chemotherapy only considers two of the eight published series (Hong, 1988); the validity of a review which ignores three-quarters of the published material must be questioned.…”

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confidence: 99%