In recent years the city of Bilbao has undergone extensive urban regeneration. Large urban infrastructural schemes were undertaken that included cultural, transport and sewerage systems. These schemes improved run-down industrial areas, contributing to urban integration and an improved quality of life for citizens and helped drive economic recovery. This empirical study is based on the activities of Bilbao Ria 2000, a public body created by government to carry out the regeneration. It analyses the impact that investment in urban infrastructure has had on the economic activity of the metropolitan area and assesses its effect on those sectors linked to the most modern processes of economic change and innovation: knowledge-intensive business services.