Editorial Focus: White matter-associated microglia (WAMs) represent an important link between aging, white matter disease and microglial activity

Roseborough, Austyn D.; Jaremek, Victoria; Whitehead, Shawn N.

doi:10.1007/s11357-021-00435-w

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Scientists have proposed the hypothesis that WAMs may serve as precursors to DAMs. In this regard, it will be significant to clarify whether WAMs can be transformed to DAMs and uncover the mechanisms by which they influence neurodegenerative processes (Roseborough et al, 2022; Shi & Holtzman, 2018). To address this question more effectively, it is essential to infer the developmental trajectories of WAMs and DAMs.…”

Section: Single‐cell Transcriptomics Analysis In Neurodegenerative Di...mentioning

confidence: 99%

Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases

He,

Chen,

Wang

et al. 2024

Eur J of Neuroscience

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Single‐cell transcriptomics analysis is an advanced technology that can describe the intracellular transcriptome in complex tissues. It profiles and analyses datasets by single‐cell RNA sequencing. Neurodegenerative diseases are identified by the abnormal apoptosis of neurons in the brain with few or no effective therapy strategies at present, which has been a growing healthcare concern and brought a great burden to society. The transcriptome of individual cells provides deep insights into previously unforeseen cellular heterogeneity and gene expression differences in neurodegenerative disorders. It detects multiple cell subsets and functional changes during pathological progression, which deepens the understanding of the molecular underpinnings and cellular basis of neurodegenerative diseases. Furthermore, the transcriptome analysis of immune cells shows the regulation of immune response. Different subtypes of immune cells and their interaction are found to contribute to disease progression. This finding enables the discovery of novel targets and biomarkers for early diagnosis. In this review, we emphasize the principles of the technology, and its recent progress in the study of cellular heterogeneity and immune mechanisms in neurodegenerative diseases. The application of single‐cell transcriptomics analysis in neurodegenerative disorders would help explore the pathogenesis of these diseases and develop novel therapeutic methods.

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Section: Single‐cell Transcriptomics Analysis In Neurodegenerative Di...mentioning

confidence: 99%

Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases

He,

Chen,

Wang

et al. 2024

Eur J of Neuroscience

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“…In aging, microglia activation appears to be shifted toward the WAM state, whereas in AD, the shift is toward DAMs. These findings suggest that WAM are precursors to DAM [ 69 ].…”

Section: The Alternative Microglia Activation Phenotypesmentioning

confidence: 99%

Different phenotypes of microglia in animal models of Alzheimer disease

Wei

2022

Immun Ageing

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Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer disease (AD) is microglial proliferation and activation concentrated around amyloid plaques in the brain. Recent research has revealed numerous microglial phenotypes related to aging and AD, apart from the traditional M1 and M2 types. Redox signalling modulates the acquisition of the classical or alternative microglia activation phenotypes. The numerous microglial functions can be achieved through these multiple phenotypes, which are associated with distinct molecular signatures.

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