TREM2, microglial and ischemic stroke

Wang, Hongxia; Li, Xiaoling; Wang, Qi; Ma, Jialiang; Gao, Xiaohong; Wang, Manxia

doi:10.1016/j.jneuroim.2023.578108

Cited by 12 publications

(5 citation statements)

References 111 publications

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“…Importantly, it should be emphasized that microglial activation and polarization in IS possess a dual nature, encompassing both neuroprotective properties and the capacity to inflict nerve damage. Previous research has demonstrated that during the subacute phase of cerebral ischemia, M1 microglia, which are responsible for initiating the inflammatory response, become activated and contribute to the progression of inflammation ( WANG et al, 2023b ). Conversely, the release of M2 microglia during ischemic recovery has been shown to play a role in stroke repair ( LIU X. et al, 2018 ).…”

Section: Relationship Between Microglia and Ischemic Strokementioning

confidence: 99%

“…Glucose transporters facilitate the transportation of glucose and other hexoses, with GLUT1 being identified as the most proficient transport system across the BBB ( ANRAKU et al, 2017 ). Research has demonstrated that the glycosylation-modified drug delivery system can be selectively acknowledged and transported by GLUT1 ( FU et al, 2019 ; WANG et al, 2022b ). Conducted a study wherein they devised and synthesized two variations of glycosylated quercetin, namely, GLU-Que (modified with a single glucose group) and 2GLU-Que (modified with two glucose groups).…”

Section: Drug-delivery Systemsmentioning

confidence: 99%

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Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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Ischemic stroke is a prevalent clinical condition affecting the central nervous system, characterized by a high mortality and disability rate. Its incidence is progressively rising, particularly among younger individuals, posing a significant threat to human well-being. The activation and polarization of microglia, leading to pro-inflammatory and anti-inflammatory responses, are widely recognized as pivotal factors in the pathogenesis of cerebral ischemia and reperfusion injury. Traditional Chinese herbal medicines (TCHMs) boasts a rich historical background, notable efficacy, and minimal adverse effects. It exerts its effects by modulating microglia activation and polarization, suppressing inflammatory responses, and ameliorating nerve injury through the mediation of microglia and various associated pathways (such as NF-κB signaling pathway, Toll-like signaling pathway, Notch signaling pathway, AMPK signaling pathway, MAPK signaling pathway, among others). Consequently, this article focuses on microglia as a therapeutic target, reviewing relevant pathway of literature on TCHMs to mitigate neuroinflammation and mediate IS injury, while also exploring research on drug delivery of TCHMs. The ultimate goal is to provide new insights that can contribute to the clinical management of IS using TCHMs.

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Section: Relationship Between Microglia and Ischemic Strokementioning

confidence: 99%

Section: Drug-delivery Systemsmentioning

confidence: 99%

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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“…One of its ligands, HSP60, stimulates TREM2 to activate microglial phagocytosis, and the absence of TREM2 promotes inflammation. 75 , 76 In addition, zinc released from neurons after injury has been shown to trigger microglial activation by sequentially activating nicotinamide adenine dinucleotide phosphate oxidase, poly (ADP-ribose) polymerase-1 (PARP-1), and nuclear factor kappa B (NF-κB). 77 However, when microglia become over-activated, it can result in neuronal dysfunction, oxidative stress, and neuroinflammation.…”

Section: The Role Of Microglia In Ischemic Brainmentioning

confidence: 99%

Microglia in Ischemic Stroke: Pathogenesis Insights and Therapeutic Challenges

Shui,

Chen,

et al. 2024

JIR

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Ischemic stroke is the most common type of stroke, which is the main cause of death and disability on a global scale. As the primary immune cells in the brain that are crucial for preserving homeostasis of the central nervous system microenvironment, microglia have been found to exhibit dual or even multiple effects at different stages of ischemic stroke. The anti-inflammatory polarization of microglia and release of neurotrophic factors may provide benefits by promoting neurological recovery at the lesion in the early phase after ischemic stroke. However, the pro-inflammatory polarization of microglia and secretion of inflammatory factors in the later phase of injury may exacerbate the ischemic lesion, suggesting the therapeutic potential of modulating the balance of microglial polarization to predispose them to anti-inflammatory transformation in ischemic stroke. Microglia-mediated signaling crosstalk with other cells may also be key to improving functional outcomes following ischemic stroke. Thus, this review provides an overview of microglial functions and responses under physiological and ischemic stroke conditions, including microglial activation, polarization, and interactions with other cells. We focus on approaches that promote anti-inflammatory polarization of microglia, inhibit microglial activation, and enhance beneficial cell-to-cell interactions. These targets may hold promise for the creation of innovative therapeutic strategies.

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“…Another group performed a comparison between tMCAO and 5xFAD mice [106]. In total, 401 genes were identified, including recently reported common genes such as TREM2 [107]. The functional annotations of these genes were also related to the immune system.…”

Section: Crosstalk Between Transcriptomic Data Of Is and Admentioning

confidence: 99%

Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?

Filippenkov,

Khrunin,

Mozgovoy

et al. 2023

Biomedicines

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Complex diseases that affect the functioning of the central nervous system pose a major problem for modern society. Among these, ischemic stroke (IS) holds a special place as one of the most common causes of disability and mortality worldwide. Furthermore, Alzheimer’s disease (AD) ranks first among neurodegenerative diseases, drastically reducing brain activity and overall life quality and duration. Recent studies have shown that AD and IS share several common risk and pathogenic factors, such as an overlapping genomic architecture and molecular signature. In this review, we will summarize the genomics and RNA biology studies of IS and AD, discussing the interconnected nature of these pathologies. Additionally, we highlight specific genomic points and RNA molecules that can serve as potential tools in predicting the risks of diseases and developing effective therapies in the future.

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TREM2, microglial and ischemic stroke

Cited by 12 publications

References 111 publications

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Microglia in Ischemic Stroke: Pathogenesis Insights and Therapeutic Challenges

Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?

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