Editorial: Fluid Therapy in Animals: Physiologic Principles and Contemporary Fluid Resuscitation Considerations

Muir, William W.; Hughes, Dez; Silverstein, Deborah C.

doi:10.3389/fvets.2021.744080

Cited by 3 publications

(1 citation statement)

References 256 publications

(179 reference statements)

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“…This approach is based on the hypothesis that accurately tailoring the uid treatment to an animal's physiological requirements is vital, particularly in instances of shock and substantial uid depletion, in which the selection and composition of the supplied uid can exert a considerable impact on the outcomes. The physiology of uid compartments in animals, such as pigs, is intricate, and the selection of uid therapy must consider elements such as the distribution of blood volume, the function of various capillaries in uid exchange, and the body's general maintenance of water balance (22).…”

Section: Discussionmentioning

confidence: 99%

Preliminary Research on Tailored Fluid Therapy in Pigs: Comparing Customized Ionic Solutions with Hartmann's Solution

Lee,

Han

et al. 2024

Preprint

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Background Fluid therapy in veterinary medicine is pivotal for treating various conditions in pigs; however, standard solutions, such as Hartmann's solution, may not optimally align with pig physiology. This study explored the development and efficacy of a customized fluid therapy tailored to the ionic concentrations of pig blood, aiming to enhance treatment outcomes and safety in both healthy and diseased pigs. Results The study involved two experiments: the first to assess the safety and stability of customized fluids in healthy pigs, and the second to evaluate the efficacy in pigs with clinical symptoms of dehydration. In healthy pigs, the administration of customized fluids showed no adverse effects, with slight alterations observed in pO2, Hematocrit, and glucose levels in some groups. In symptomatic pigs, the customized fluid group did not show any improvement in clinical symptoms, with no significant changes in blood chemistry or metabolite levels compared to controls. The customized fluid group showed a mild increase in some values after administration, yet within normal physiological ranges. The study reported no significant improvements in clinical or dehydration status, attributing the observed variations in blood test results to the limited sample size and anaesthesia effects rather than fluid characteristics. Conclusions Customized fluid therapy, tailored to mimic the ionic concentrations of pig blood, appears to be a safe and potentially more effective alternative to conventional solutions such as Hartmann’s solution for treating pigs under various health conditions. Further research with larger sample sizes and controlled conditions is recommended to validate these findings and to explore the full potential of customized fluid therapy in veterinary practice.

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Section: Discussionmentioning

confidence: 99%