2023
DOI: 10.1007/s12028-023-01802-5
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Can a Therapeutic Strategy for Hypotension Improve Cerebral Perfusion and Oxygenation in an Experimental Model of Hemorrhagic Shock and Severe Traumatic Brain Injury?

Ana Paula de Carvalho Canela Balzi,
Denise Aya Otsuki,
Lucia Andrade
et al.
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Cited by 2 publications
(1 citation statement)
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“…Contrasting these positive outcomes, a prospective, single-blind study in humans under anesthesia found that while arginine vasopressin prevented hypotension, it adversely affected cerebral tissue oxygen saturation, causing increased cerebral desaturation compared to a control group receiving normal saline [113]. Similarly, a recent animal study investigating terlipressin effectiveness in restoring cerebral oxygenation in TBI and hemorrhagic shock models found no improvement in cerebral perfusion pressure or cerebral oximetry, despite hemodynamic recovery across all study groups [114].…”
Section: Cerebral Oxygenation Effectsmentioning
confidence: 99%
“…Contrasting these positive outcomes, a prospective, single-blind study in humans under anesthesia found that while arginine vasopressin prevented hypotension, it adversely affected cerebral tissue oxygen saturation, causing increased cerebral desaturation compared to a control group receiving normal saline [113]. Similarly, a recent animal study investigating terlipressin effectiveness in restoring cerebral oxygenation in TBI and hemorrhagic shock models found no improvement in cerebral perfusion pressure or cerebral oximetry, despite hemodynamic recovery across all study groups [114].…”
Section: Cerebral Oxygenation Effectsmentioning
confidence: 99%