Editorial: Effects of Androgens on Immunity to Self and Foreign

Jørgensen, Trine N.; Kovats, Susan; Lotter, Hanna

doi:10.3389/fimmu.2020.630066

Cited by 4 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has also been shown that in females, androgens can directly induce the conversion of peripheral blood T cells into Tregs 97,98 . Furthermore, testosterone has been associated with immunosuppression during infectious diseases, autoimmune diseases, and cancer 99 …”

Section: Mechanisms Of Androgen-mediated Immune Tolerance and Inflamm...mentioning

confidence: 99%

“…97,98 Furthermore, testosterone has been associated with immunosuppression during infectious diseases, autoimmune diseases, and cancer. 99 Previous study showed that human thymocytes express ARs. 100 Most innate and adaptive immune cells express ARs, indicating that androgens are directly involved in the regulation of the development and function of immune cells.…”

Section: Mechanisms Of Androgen-mediated Immune Tolerance In Ptbmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Shen,

Li,

Cao

et al. 2023

Maternal Fetal Med

View full text Add to dashboard Cite

In 2019, preterm births (PTB) accounted for approximately 0.66 million deaths globally. PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns. Long-term studies associated several factors, including disruption of immune tolerance and inflammation, with PTB. However, the pathogenesis of PTB remains unclear. Gonadal steroid hormones are critical for pregnancy maintenance and regulation of immune and inflammatory responses. However, it is not clear how unbalanced gonadal steroid hormones, such as imbalanced estrogen/androgen or estrogen/progesterone contribute to PTB. In this review, we discuss how gonadal steroid hormones mediate dysfunction in immune tolerance and inflammatory responses, which are known to promote the occurrence of PTB, and provide insight into PTB prediction.

show abstract

Section: Mechanisms Of Androgen-mediated Immune Tolerance and Inflamm...mentioning

confidence: 99%

Section: Mechanisms Of Androgen-mediated Immune Tolerance In Ptbmentioning

confidence: 99%

Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Shen,

Li,

Cao

et al. 2023

Maternal Fetal Med

View full text Add to dashboard Cite

show abstract

“…Жінки часто демонструють чудовий захист від інфекцій та деяких пухлин і покращують відповідь на вакцинацію через імуномодулюючу дію естрогенів та прогестерону, проте цей посилений імунітет поєднується зі збільшенням захворюваності на аутоімунні захворювання. Дослідження ролі тестостерону в інфекційних захворюваннях, аутоімунітеті та раку виявили прямий вплив дію чоловічих статевих гормонів (тестостерону, дигідротестостерону) на розвиток та функцію імунних клітин із загальним результатом імуносупресії [1,2].…”

unclassified

Effect of Androgens on Immune Cells

Martynenko¹,

Stetsuk²,

Шепітько³

et al. 2021

Act. Probl. of the Modern Med.

View full text Add to dashboard Cite

I recent years, much attention of researchers has been paid to the role of testosterone in the regulation of immune cells and its influence on the course of autoimmune diseases and inflammatory diseases. Better understanding of testosterone-regulated cellular and molecular pathways and the role of androgens in stimulating tissue-specific differences in inflammation susceptibility can lead to the development of innovative treatment strategies for a variety of diseases depending on gender. The aim of this study is to analyze the latest research on the effect of androgens on immunocompetent cells. Sex differences in the functions of the immune system are genetically determined and mediated by the action of male and female sex hormones. Myeloid immune cells express sex hormone receptors and are sensitive to sex hormones. Androgens, including dihydrotestosterone and testosterone, inhibit the activity of immune cells. Effects of testosterone restricts the activity of NK cells, the surface expression of TLR4 on macrophages, the synthesis of proinflammatory products, including TNF-α and nitric oxide synthase, and the formation of leukotriene in neutrophils. Androgens also affect inducing stimuli that regulate the activity of monocyte-macrophages. Testosterone controls complement activation. Androgens have a suppressive effect on the expression of proinflammatory cytokines, reduce the production of prostaglandin E2 in monocytes. The presence of androgen receptors is important factor in regulating neutrophil differentiation. Androgen receptors regulate, first of all, the transition between the proliferation of precursors (myeloblasts, promyelocytes and myelocytes) and the maturation of neutrophils (metamyelocytes, band and segmented neutrophils). The number and activity of cells associated with innate immunity differ between the sexes. Males have a higher natural killer (NK) percentage than females. Phagocytic activity of neutrophils and macrophages in women is higher than in men. Antigen-presenting cells in women are more efficiently presented by peptides than in men. Sex differences are also observed in innate lymphoid cells, which are lymphocytes that regulate a number of tissue immune responses by producing effector cytokines.

show abstract

Sex, Gender, and Other Factors That Influence Infections for Men and Women

Johnson,

Baldwin,

Bruner

et al. 2024

Infect Dis Clin Pract

View full text Add to dashboard Cite

In this review, the anatomical, physiological, immunological, societal, and behavioral differences that influence infections for men and women will be reviewed followed by a discussion of differences in vaccine responses and the nature of infections of different organ systems. This is the third in a series of reviews that examine differences in infectious disease presentation for different demographics. Previously, infectious disease differences were compared for children and for older adults. This and the previous reviews are highly appropriate for sharing with, and educating colleagues, residents and students.

show abstract

Editorial: Effects of Androgens on Immunity to Self and Foreign

Cited by 4 publications

References 5 publications

Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Effect of Androgens on Immune Cells

Sex, Gender, and Other Factors That Influence Infections for Men and Women

Contact Info

Product

Resources

About