The development over time of the Information Systems Journal and information systems (IS) research in general is examined by applying both quantitative and qualitative data analyses. The evidence suggests that the journal and the IS discipline have both evolved from parochial and national to become international. This evolution has influenced the phenomena and contexts being studied and, ultimately, theory and practice. Cultural and institutional differences are major obstacles to globalizing IS research. Based on a trilemma for theoretical development among generality, accuracy and simplicity, glocalization is suggested as an alternative to globalization. The merits of glocal research and education, with globally connected villages, are discussed.