Editorial: Bioinformatics of Genome Regulation and Systems Biology

Orlov, Yuriy L.; Baranova, Ancha

doi:10.3389/fgene.2020.00625

Cited by 30 publications

(23 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since gene regulation and genomic study provide complex data, bioinformatics and system biology are a useful approach to analyzing the findings of genomics and proteomics investigations. 12,13 Network analysis as a bioinformatics and system biology approach is used to analyze large numbers of dysregulated genes, proteins, and metabolites. Such analysis leads to find the critical macromolecules which are related to the studied diseases.…”

Section: Introductionmentioning

confidence: 99%

Gene Activation Is Introduced as Cell Protection Mechanism Against Gamma Ray Irradiation

et al. 2020

View full text Add to dashboard Cite

Introduction: Gamma radiation is accompanied by prominent biological effects and damages. Cell proliferation and tumorigenesis are highlighted as the main resulted effects of gamma radiation on cultured cells. This study aims to assess the dysregulated mode of gene function after gamma radiation in human Jurkat cells. Methods: Six gene expression profiles from Gene Expression Omnibus (GEO) were analyzed by GEO2R to find the significant differentially expressed genes (DEGs) via gamma radiation. Action map analysis was applied to screen the query DEGs. Results: Among 108 study genes, 20 critical DEGs including AURKA,

show abstract

Section: Introductionmentioning

confidence: 99%

Gene Activation Is Introduced as Cell Protection Mechanism Against Gamma Ray Irradiation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The results uncovered SNPs near clinical SNP markers as the basis of neutral drift accelerating atherogenesis and SNPs of genes encoding proteins related to mitochondrial genome integrity and microRNA genes associated with instability of the atherosclerotic plaque as a basis of directional natural selection slowing atherogenesis. Note the related bioinformatics tools papers [ 20 , 21 ] published in the Frontiers in Genetics special issue “Bioinformatics of Genome Regulation and Systems Biology” [ 22 ], and BMC Genomics issue [ 23 ]. The research topic on gene expression regulation in Frontiers in Genetics is continued in 2020.…”

mentioning

confidence: 99%

Bioinformatics Methods in Medical Genetics and Genomics

Orlov

Baranova

Tatarinova

2020

IJMS

Self Cite

View full text Add to dashboard Cite

Medical genomics relies on next-gen sequencing methods to decipher underlying molecular mechanisms of gene expression. This special issue collects materials originally presented at the “Centenary of Human Population Genetics” Conference-2019, in Moscow. Here we present some recent developments in computational methods tested on actual medical genetics problems dissected through genomics, transcriptomics and proteomics data analysis, gene networks, protein–protein interactions and biomedical literature mining. We have selected materials based on systems biology approaches, database mining. These methods and algorithms were discussed at the Digital Medical Forum-2019, organized by I.M. Sechenov First Moscow State Medical University presenting bioinformatics approaches for the drug targets discovery in cancer, its computational support, and digitalization of medical research, as well as at “Systems Biology and Bioinformatics”-2019 (SBB-2019) Young Scientists School in Novosibirsk, Russia. Selected recent advancements discussed at these events in the medical genomics and genetics areas are based on novel bioinformatics tools.

show abstract

“…The SBB School series on bioinformatics is organized annually since 2008 by the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences and Novosibirsk State University [ 1 ]. We have published selected conference materials as special issues at BMC Genetics and related BioMed Central journals [ 2 – 5 ].…”

mentioning

confidence: 99%