Bioinformatics Methods in Medical Genetics and Genomics

Abstract

Medical genomics relies on next-gen sequencing methods to decipher underlying molecular mechanisms of gene expression. This special issue collects materials originally presented at the “Centenary of Human Population Genetics” Conference-2019, in Moscow. Here we present some recent developments in computational methods tested on actual medical genetics problems dissected through genomics, transcriptomics and proteomics data analysis, gene networks, protein–protein interactions and biomedical literature mining. We have selected materials based on systems biology approaches, database mining. These methods and algorithms were discussed at the Digital Medical Forum-2019, organized by I.M. Sechenov First Moscow State Medical University presenting bioinformatics approaches for the drug targets discovery in cancer, its computational support, and digitalization of medical research, as well as at “Systems Biology and Bioinformatics”-2019 (SBB-2019) Young Scientists School in Novosibirsk, Russia. Selected recent advancements discussed at these events in the medical genomics and genetics areas are based on novel bioinformatics tools.

Bioinformatics Applications to Reveal Molecular Mechanisms of Gene Expression Regulation in Model Organisms

“…The presented analytic techniques were discussed at the BGRS-2020 (Bioinformatics of Genome Regulation and Structure/Systems Biology) biannual computational biology meeting in Novosibirsk, highlighting recent advances in the evolution, biomedicine, and biotechnology areas. This collection continues the studies in the field of bioinformatics of gene expression initially presented in Frontiers in Genetics [ 1 ], PeerJ ( ), and then in International Journal of Molecular Sciences [ 2 ].…”

“…The current Special Issue contains eight research manuscripts and one review, each concerning a model or a pipeline applied to extract information useful for understanding the molecular mechanisms of gene expression regulation. We continue the previously published set of paper collections with an overarching theme of bioinformatics initially focused only on biomedical applications ( ) [ 2 , 3 ]. This Special Issue is focused on the deciphering of the molecular mechanisms underpinning chronic diseases and disorders.…”

“…Thus, the current Special Issue on bioinformatics shows that gene expression regulation studies are in high demand [ 1 , 2 ]. The guest editors are happy to announce the Special Issue topic at MDPI IJMS on medical genomics ( ) and next BGRS-2022 conference in Russia ( ).…”

Medical Genetics, Genomics and Bioinformatics Aid in Understanding Molecular Mechanisms of Human Diseases

“…The current Special Issue contains eight research manuscripts and two reviews, each concerning some model or a pipeline applied to extract information useful for understanding molecular underpinning for a human disease and suggestive of a mechanism-specific treatment. We continue the previously published set of paper collections with an overarching theme of bioinformatics and medical genetics, which began in 2019 ( , accessed on 25 August 2021) [ 1 ]. This Special Issue is focused on the deciphering of molecular mechanisms underpinning common chronic diseases, including mental disorders, and emphasizing searches for drug targets.…”

Bioinformatics of genome regulation and structure – 2020 papers collection

“…The BGRS conference series on bioinformatics proceeds annually since 1998 under the joint steerage of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences and Novosibirsk State University [ 7 ], [ 8 ]. Overall focus of the conference was on the analysis of gene expression regulation in a genome on systems level – such as gene networks and systems biology models [ 9 ]. The authors were co-organizers of BGRS meetings and later satellite society meetings on bioinformatics, such as Russian-German Virtual Bioinformatics Network, Sino-Russian workshops on bioinformatics [ 10 ] ( http://www.zjbioinformatics.org/meetings/2020/index.html ; http://glab.hzau.edu.cn/BioInfo/index.html ).…”