Editorial

Klengel, Susanne

doi:10.1515/iber-2017-0029

Cited by 1 publication

(2 citation statements)

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“…Fat-suppressed proton density-weighted MRI mainly detects protons derived from water, and sweat is mostly water, although it also contains electrolytes, fatty acids, lactic acid, urea and uric acid. [1,13,15,16] However, whether the proton density-weighted F I G U R E 2 Fluid secretion of 3D reconstructed eccrine sweat glands detected by the fat-suppressed proton density-weighted MRI sequence. Images of the plugs and the selected ROIs (A, B).…”

Section: Discussionmentioning

confidence: 99%

“…[11,14] Proton density-weighted imaging mainly reflects the differences in proton density, primarily hydrogen atoms, among different tissues and organs, so when the signal from fat is suppressed, the detected hydrogen atoms are mainly derived from water. [13,15,16] In this study, we determined the fluid secretion of 3D reconstructed and native eccrine sweat glands by fat-suppressed proton density-weighted MRI. The results show that there is a clear increase in mean proton intensity after pilocarpine injection compared with that before pilocarpine injection, in both the 3D reconstructed and native eccrine sweat glands.…”

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confidence: 99%

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Detection of fluid secretion of three‐dimensional reconstructed eccrine sweat glands by magnetic resonance imaging

Chen

Zhang

et al. 2019

Experimental Dermatology

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We previously showed three‐dimensional (3D) reconstructed eccrine sweat glands have similar structures as native eccrine sweat glands, but whether the 3D reconstructed sweat glands appropriately secrete fluid is still unknown. In this study, Matrigel‐embedded human eccrine sweat gland cells or Matrigel alone were implanted into the groin subcutis of the nude mice. Ten weeks post‐implantation, images of the subcutaneously formed plugs, as well as footpads of rats, pre‐ and post‐pilocarpine/normal saline (NS) injection were acquired using a fat‐suppressed proton density‐weighted magnetic resonance imaging (MRI) sequence at 7.0 T, and the regions of interest (ROIs) in plugs and rat footpads were analysed and graphed. A significant increase in the ROI mean proton intensity occurred in both 3D reconstructed and native eccrine sweat glands after pilocarpine injection. The mean proton intensity had no noticeable changes in ROIs of Matrigel plugs between pre‐ and post‐pilocarpine injection, and in ROIs of rat footpads between pre‐ and post‐NS injection. In conclusion, the 3D reconstructed sweat glands possess fluid secretion, which is detectable by fat‐suppressed proton density‐weighted MRI.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%