1992
DOI: 10.1128/jvi.66.8.4693-4697.1992
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Abstract: It has been shown previously that during replication of the genome of human hepatitis delta virus (HDV), a specific nucleotide change occurs to eliminate the termination codon for the small delta antigen (G. Luo, M.

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Cited by 78 publications
(15 citation statements)
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References 17 publications
(15 reference statements)
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“…The P proteins from members of the genera Morbillivirus, Respirovirus, Henipavirus, and Avulavirus are ex-pressed from unedited transcripts, whereas the V and W/D (W protein in Nipah virus and D protein in bovine parainfluenza virus 3) proteins require the insertion of one or two guanosine residues into the editing site, respectively (7,22,24,32,50). Transcriptional editing has also been observed in both the genomic and antigenomic RNA of hepatitis delta virus (HDV) (5,6,60). For paramyxoviruses it has been postulated that RNA editing occurs through a mechanism of RNA-dependent RNA polymerase stuttering during template elongation, similar to the polyadenylation of RNA transcripts, indicating that editing sites may have evolved from polyadenylation sites (16).…”
Section: Discussionmentioning
confidence: 99%
“…The P proteins from members of the genera Morbillivirus, Respirovirus, Henipavirus, and Avulavirus are ex-pressed from unedited transcripts, whereas the V and W/D (W protein in Nipah virus and D protein in bovine parainfluenza virus 3) proteins require the insertion of one or two guanosine residues into the editing site, respectively (7,22,24,32,50). Transcriptional editing has also been observed in both the genomic and antigenomic RNA of hepatitis delta virus (HDV) (5,6,60). For paramyxoviruses it has been postulated that RNA editing occurs through a mechanism of RNA-dependent RNA polymerase stuttering during template elongation, similar to the polyadenylation of RNA transcripts, indicating that editing sites may have evolved from polyadenylation sites (16).…”
Section: Discussionmentioning
confidence: 99%
“…97,98 Subsequent work concluded that the genomic strand of HDV is the actual editing substrate, and that for this to occur, sequences from the apposing side of the rod-structure need to be present. 99,100 More recent findings however suggest that in fact, the antigenomic RNA of HDV is the target for HDV-RNA editing, which is therefore a conversion from A to G 101,102 and the enzyme involved is possibly the host double-stranded RNA adenosine deaminase. 101 It is now clear that the editing of the RNA, and production of the two HDAgs, are essential steps in the life cycle of HDV, the latter with distinct biological activities as explained later.…”
Section: Hepatitis Delta Antigenmentioning
confidence: 99%
“…The base modification is occuixing in a U-G vi'obble pair in midst of 8 Watson-Crick base pairs. This base paired structure is necessary for efficient editing in vivo (Casey et al 1992) or in vitro (Zheng et al 1992). ff templates related by base pairing with target sites are proposed for plan!…”
Section: Mechanism Of Editingmentioning
confidence: 99%
“…Otlier mechanisms of RNA editing are the modification of some residues withotjt affecting the reading frame. This is the case of editing in matumals (Powell et al 1987, Sommer et al 1991, hepatitis delta virus (Zheng et al 1992) and plant organelles. In land plants tbus far investigated, except for the bryophyte Marchantia polytnorpha (Oda et al 1992), the RNA editing proeess has been described in mitochondria and chloroplasts.…”
Section: Introductionmentioning
confidence: 99%