Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds

Schepers, Melissa; Martens, Nikita; Tiane, Assia; Vanbrabant, Kenneth; Liu, Hongbing; Lütjohann, Dieter; Mulder, Monique; Vanmierlo, Tim

doi:10.4103/1673-5374.268894

Cited by 41 publications

(47 citation statements)

References 47 publications

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“…More recently, Schepers et al (2020) highlighted in a review article prominent neuroactive effects of PSs derived from marine origin. As main statements, the authors clearly highlighted the ability of fucosterol, 24(S)-saringosterol, sitosterol, and stigmasterol to reduce Aβ plaque formation; the ability of fucosterol and 24(S)-saringosterol to counteracts memory deficits; the ability of fucosterol to increase the acetylcholine levels in the brain; and the ability of 24(S)-saringosterol to increase Aβ clearance ( Schepers et al, 2020 ).…”

Section: Preclinical Pharmacological Activities Of Phytosterolsmentioning

confidence: 99%

Phytosterols: From Preclinical Evidence to Potential Clinical Applications

et al. 2021

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Phytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by several factors (type, source, processing, preparation, delivery method, food matrix, dose, time of administration into the body, and genetic factors), and the existence of a close relationship between their chemical structures (e.g., saturation degree and side-chain length) and low absorption rates has been stated. In this sense, the present review intends to provide in-depth data on PS therapeutic potential for human health, also emphasizing their preclinical effects and bioavailability-related issues.

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Section: Preclinical Pharmacological Activities Of Phytosterolsmentioning

confidence: 99%

Phytosterols: From Preclinical Evidence to Potential Clinical Applications

et al. 2021

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“…Fucoidan has been shown to increase GPX levels and prevent ROS production [37]. High levels of acetylcholinesterase cause cholinergic dysfunction, which leads to memory loss in AD patients.…”

Section: The Mechanism Of Polysaccharides From Seaweeds For the Treatmentioning

confidence: 99%

“…Neuroinflammation is a controlling factor for both damage and repair of brain tissue [37]. Inflammatory responses are present around amyloid-beta plaques in AD [41].…”

Section: The Mechanism Of Polysaccharides From Seaweeds For the Treatmentioning

confidence: 99%

The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer’s Disease

et al. 2021

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Neurodegenerative diseases are among the most widespread diseases affecting humans, and the number of patients is only rising. Seaweed polysaccharide extracts show significant neuroprotective and reparative activities. Seaweed polysaccharides might provide the next big breakthrough in neurodegenerative disease treatment. This paper reviews the applications of seaweed polysaccharides as potential treatments of neurodegenerative diseases. The particular focus is on fucoidan, ulvan, and their derivatives as potential agents to treat Alzheimer’s disease. This review provides a critical update on the progress in this important research area.

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“…Nutraceuticals are largely present in fruit, vegetables, cereals, herbs used in the human nutrition, with pleiotropic antioxidant, anti-inflammatory, glycemia-regulating properties able to preserve brain (Kennedy and Wightman, 2011;Gonzalez et al, 2019) with fewer side-effects than synthetic drugs (Georgiou et al, 2011;Forni et al, 2019). Recently, an important source of neuroprotective compounds like phytosterols, carotenoids, fucoidans and polyphenols have been characterized also in seaweeds consumed in China and Indonesia (Schepers et al, 2020). Most of them are effective anti-inflammatory and antioxidants and preserve dendritic spine density in hippocampal neurons.…”

Section: Nutraceuticals Effective In Neurodegeneration Via Autophagymentioning

confidence: 99%

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Stacchiotti

Corsetti

2020

Front. Cell Dev. Biol.

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Prolonging the healthy life span and limiting neurological illness are imperative goals in gerontology. Age-related neurodegeneration is progressive and leads to severe diseases affecting motility, memory, cognitive function, and social life. To date, no effective treatments are available for neurodegeneration and irreversible neuronal loss. Bioactive phytochemicals could represent a natural alternative to ensure active aging and slow onset of neurodegenerative diseases in elderly patients. Autophagy or macroautophagy is an evolutionarily conserved clearing process that is needed to remove aggregateprone proteins and organelles in neurons and glia. It also is crucial in synaptic plasticity. Aberrant autophagy has a key role in aging and neurodegeneration. Recent evidence indicates that polyphenols like resveratrol and curcumin, flavonoids, like quercetin, polyamine, like spermidine and sugars, like trehalose, limit brain damage in vitro and in vivo. Their common mechanism of action leads to restoration of efficient autophagy by dismantling misfolded proteins and dysfunctional mitochondria. This review focuses on the role of dietary phytochemicals as modulators of autophagy to fight Alzheimer's and Parkinson's diseases, fronto-temporal dementia, amyotrophic lateral sclerosis, and psychiatric disorders. Currently, most studies have involved in vitro or preclinical animal models, and the therapeutic use of phytochemicals in patients remains limited.

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Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds

Cited by 41 publications

References 47 publications

Phytosterols: From Preclinical Evidence to Potential Clinical Applications

Phytosterols: From Preclinical Evidence to Potential Clinical Applications

The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer’s Disease

Natural Compounds and Autophagy: Allies Against Neurodegeneration

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