The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer’s Disease

Bauer, Sarah; Jin, Weihua; Zhang, Fuming; Linhardt, Robert J.

doi:10.3390/md19020089

Cited by 45 publications

(26 citation statements)

References 49 publications

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“…Several studies highlight the use of algal polysaccharides for the treatment of neurodegenerative diseases as referred by Bauer et al [143]. Park et al [144] demonstrated improved memory and learning in mice treated with fucoidan extracts from Ecklonia cava; thus, the study suggests promising results in future human trials [144].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

An Overview to the Health Benefits of Seaweeds Consumption

2021

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Currently, seaweeds are gaining major attention due to the benefits they give to our health. Recent studies demonstrate the high nutritional value of seaweeds and the powerful properties that seaweeds’ bioactive compounds provide. Species of class Phaeophyceae, phylum Rhodophyta and Chlorophyta possess unique compounds with several properties that are potential allies of our health, which make them valuable compounds to be involved in biotechnological applications. In this review, the health benefits given by consumption of seaweeds as whole food or by assumption of bioactive compounds trough natural drugs are highlighted. The use of seaweeds in agriculture is also highlighted, as they assure soils and crops free from chemicals; thus, it is advantageous for our health. The addition of seaweed extracts in food, nutraceutical, pharmaceutical and industrial companies will enhance the production and consumption/usage of seaweed-based products. Therefore, there is the need to implement the research on seaweeds, with the aim to identify more bioactive compounds, which may assure benefits to human and animal health.

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Section: Biomedical Applicationsmentioning

confidence: 99%

An Overview to the Health Benefits of Seaweeds Consumption

2021

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“…contained seven active compounds that inhibited the seasonal influenza viruses A and B in MDCK (Madin–Darby Canine Kidney)-infected cells [ 143 ]. The sulfated polysaccharide fractions from red algae Kappaphycus alvarezii , Porphyridium , and Hypnea musciformis showed strong protective activity against HIV-1-induced T-lymphoblastic cells [ 144 ]. A ZK antigenic protein served as a vaccine against the Zika virus; it can be produced from Schizochytrium sp.…”

Section: Clinically Important Compoundsmentioning

confidence: 99%

Microalgal Biorefinery Concepts’ Developments for Biofuel and Bioproducts: Current Perspective and Bottlenecks

Sivaramakrishnan

Suresh

Kanwal

et al. 2022

IJMS

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Microalgae have received much interest as a biofuel feedstock. However, the economic feasibility of biofuel production from microalgae does not satisfy capital investors. Apart from the biofuels, it is necessary to produce high-value co-products from microalgae fraction to satisfy the economic aspects of microalgae biorefinery. In addition, microalgae-based wastewater treatment is considered as an alternative for the conventional wastewater treatment in terms of energy consumption, which is suitable for microalgae biorefinery approaches. The energy consumption of a microalgae wastewater treatment system (0.2 kW/h/m3) was reduced 10 times when compared to the conventional wastewater treatment system (to 2 kW/h/m3). Microalgae are rich in various biomolecules such as carbohydrates, proteins, lipids, pigments, vitamins, and antioxidants; all these valuable products can be utilized by nutritional, pharmaceutical, and cosmetic industries. There are several bottlenecks associated with microalgae biorefinery. Hence, it is essential to promote the sustainability of microalgal biorefinery with innovative ideas to produce biofuel with high-value products. This review attempted to bring out the trends and promising solutions to realize microalgal production of multiple products at an industrial scale. New perspectives and current challenges are discussed for the development of algal biorefinery concepts.

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“…Sulfated marine glycans have shown a wide range of medical applications, including antiviral activity [ 108 ]. Since the natural host cell receptor, HS is a sulfated GAG using sulfated marine glycans as an antiviral treatment should inhibit virus binding.…”

Section: Potential Prophylactic and Therapeutic Applications Of Gags In The Treatments Of Viral Zoonotic Diseasesmentioning

confidence: 99%

“…GAGs are sulfated polysaccharide chains, so it stands to reason that other polysaccharides, having similar structures and sulfation content, might also provide similar results. Sulfated polysaccharides such as fucoidan are readily available in seaweed globally and could provide another treatment option [ 108 ]. GAGs and their derivatives (some of which have low or no anticoagulant activity) could represent a class of antiviral drugs against a myriad of viruses.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Implications of Glycosaminoglycans on Viral Zoonotic Diseases

2021

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Zoonotic diseases are infectious diseases that pass from animals to humans. These include diseases caused by viruses, bacteria, fungi, and parasites and can be transmitted through close contact or through an intermediate insect vector. Many of the world’s most problematic zoonotic diseases are viral diseases originating from animal spillovers. The Spanish influenza pandemic, Ebola outbreaks in Africa, and the current SARS-CoV-2 pandemic are thought to have started with humans interacting closely with infected animals. As the human population grows and encroaches on more and more natural habitats, these incidents will only increase in frequency. Because of this trend, new treatments and prevention strategies are being explored. Glycosaminoglycans (GAGs) are complex linear polysaccharides that are ubiquitously present on the surfaces of most human and animal cells. In many infectious diseases, the interactions between GAGs and zoonotic pathogens correspond to the first contact that results in the infection of host cells. In recent years, researchers have made progress in understanding the extraordinary roles of GAGs in the pathogenesis of zoonotic diseases, suggesting potential therapeutic avenues for using GAGs in the treatment of these diseases. This review examines the role of GAGs in the progression, prevention, and treatment of different zoonotic diseases caused by viruses.

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The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer’s Disease

Cited by 45 publications

References 49 publications

An Overview to the Health Benefits of Seaweeds Consumption

An Overview to the Health Benefits of Seaweeds Consumption

Microalgal Biorefinery Concepts’ Developments for Biofuel and Bioproducts: Current Perspective and Bottlenecks

Implications of Glycosaminoglycans on Viral Zoonotic Diseases

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